Flow resistance reduction, quantified as a change in flow rate with respect to a reference isothermal flow driven by the same pressure gradient, is realizable in a channel flow using a thermal wave applied on the bounding wall. Countercurrent waves provide a resistance-reducing effect at any wave velocity, Reynolds number and wavenumber considered. Cocurrent waves can reduce resistance only if the wave velocity is lower than a certain threshold, and the Reynolds number is larger than a certain threshold, otherwise, such waves increase resistance. The increase of the wave amplitude increases resistance reduction and resistance increase up to a specific limit. It is possible to reduce resistance up to 20 times compared with the isothermal channel using proper waves. It is shown that the same effect is achieved regardless of the waves applied at the upper and lower walls. The wave-modified flows are shown to be stable for the conditions used in this study.