Flow Measurements Research Articles

A multivariable submersible sensor for monitoring in real-time industrial flotation cells

This paper describes the development and validation of a submersible sensing technology for industrial flotation cells. The sensor provides simultaneous real-time measurements of gas and solid holdups, as well as the density and viscosity of the slurry in the pulp zone of flotation machines. The submersible device comprises a gas exclusion cell, which resembles an inverted truncated cone assembled to a single-straight tube Coriolis meter. When the sensor device is vertically immersed in the aerated slurry, a continuous bubble-free flow of slurry is induced through the device, which allows the Coriolis meter to provide measurements of the slurry flow, density, and viscosity. The magnitude of the induced flow is a primary function of the sensor’s geometry and gas holdup. Applying the Bernoulli equation reveals that gas holdup can be expressed as the square of the induced flow velocity. A discharge coefficient parameter is introduced to compensate for variations in the velocity profile and flow losses. This coefficient is a function of the fluid Reynolds number, calculated in real-time based on the Coriolis measurements. The sensing technology was assessed in a pilot column operated in a water–air system and industrial forced-air and self-aspirated large flotation cells. Results demonstrate the sensor’s capabilities to provide reliable, accurate, real-time, long-term continuous gas dispersion and solid suspension-related variables, which could be used for supervision, control, and optimization applications.

A novel functional index, aortic-valve-coefficient, for assessing aortic-stenosis in patients undergoing TAVR: A prospective-pilot study

BackgroundEvaluating the severity of aortic stenosis (AS) can be challenging, particularly in patients with low-gradient (LG, Δp < 40 mmHg) AS. Objective: This study aims to improve the accuracy of assessing severity of AS using a novel functional index- Aortic Valve Coefficient (AVC). The AVC is defined as ratio of mean transvalvular pressure-drop (Δp) to the proximal dynamic pressure (1/2 × blood density × VLVOT2; VLVOT: left ventricular outflow tract peak velocity). Hypothesis: AVC, developed from fundamental fluid dynamic principles, is a better index for accessing AS severity as it incorporates square of VLVOT and downstream pressure recovery. MethodsThis pilot prospective study enrolled 47 patients undergoing TAVR for AS. Using cardiac-catheterization-measured Δp and echocardiography-Doppler-derived VLVOT, AVC was evaluated. Pre- and post-TAVR pressure-velocity measurements were obtained, resulting in a dataset with 78 data points, including 32 data points specifically linked to LG AS. Linear regression analysis was performed to correlate AVC with Δp, VLVOT and aortic-valve-area. Welch 2-sample t-test was carried out to compare the means of AVC against aortic-valve-area. ResultsModerate correlation (r = 0.85) was observed between AVC and aortic-valve-area indicating AVC could be a prospective index. However, correlation decreased (r = 0.75) in LG AS patients, indicating increased discordancy. Comparing AVC and aortic-valve-area in LG AS patients with left ventricular ejection fraction (LVEF) < 50 % and LVEF ≥50 %, t-test showed that AVC values are significantly different (p < 0.05) as compared to aortic-valve-area (p = 0.48). ConclusionAVC, a novel index, has the potential to improve assessment of AS severity and clinical decision making for treating patients with AS. Condensed abstractComplex hemodynamics, such as paradoxical “low-flow low-gradient (LG)” Aortic stenosis (AS) can be difficult to diagnose. Currently, mean transvalvular pressure-drop and flow-derived aortic-valve-area assess AS severity. Aortic valve coefficient (AVC) is a novel index which combines both pressure-drop and flow measurements to assess the severity of AS. A total of 47 patients (72 data points) were studied undergoing TAVR. In LG AS patients, t-test comparing left ventricular ejection fraction (LVEF) < 50 % and LVEF ≥50 % showed that AVC are significantly different (p < 0.05) as compared to aortic-valve-area (p = 0.48). Therefore, AVC could be a better index.

Experimental evaluation of various flow meters using gaseous CO2

The need for accurate flow measurement within the Carbon Capture, Utilisation and Storage (CCUS) transport network is widely reported and understood as a requirement of Emission Trading Schemes and commercial contracts. In meeting this requirement, traceable calibration is needed in conditions which closely mimic the process conditions. However, currently accredited calibration facilities cannot meet the conditions for calibrating in gaseous CO2 and so a likely alternative solution for these custody transfer flow meters is to be calibrated with an alternative fluid and the calibration transferred. In this article, which was produced under the framework of the EMPIR project “Metrology for Decarbonising the Gas Grid”, the authors will investigate this approach with a number of flow meters tested in natural gas, nitrogen gas and finally in carbon dioxide gas at varying pressures. The results of which will suggest that orifice and Coriolis meters can be calibrated in another fluid however, an ultrasonic meter would require further work and potentially require calibration in CO2. This article will also investigate the effects of impurities in a CO2 gas stream for a rotary displacement flow meter and a thermal mass flow controller compared against a piston prover which provides a primary reference flow standard.

Design and characterisation of an open-jet pressure gradient test rig for an aeroacoustic wind tunnel

This paper summarises an approach to generating controllable pressure gradients within an open-jet configuration for aeroacoustics research. A novel open-jet pressure gradient test rig has been designed for the UNSW Anechoic Wind Tunnel with the help of RANS simulations. A range of pressure gradients is created by adjusting the inclination angle of the top plate to change the cross-sectional area along the streamwise direction gradually. The test model mounting point is located on the bottom plate adjacent to partially opened side walls to allow far-field noise measurements. A comprehensive characterisation of flow quality, pressure gradient parameters and acoustic data quality has been carried out using Particle Imaging Velocimetry (PIV), surface pressure taps, and a microphone array. The test rig produces near-uniform pressure gradient flows at the model mounting point, with momentum Reynolds numbers (Reθ) ranging from 3014 to 11853 and Clauser's pressure gradient parameters (β) from -0.24 to 1.66. The pressure gradients generated by this facility are approximately linear, approaching the model mounting point, and the boundary layer profiles compare favourably with those from conventional hard-walled enclosed pressure gradient wind tunnel facilities. Measurements of airfoil trailing-edge noise from this test rig compare well with classical semi-empirical model predictions. Simultaneous acoustic and flow measurements on a square finite wall-mounted cylinder showcase the capability of this facility for coupled acoustic-flow diagnosis.

Improving large angle flow measurement accuracy of five-hole probe using novel calibration coefficient and accuracy progressive neural network

Novel calibration coefficients and data-fitting techniques based on a two-stage accuracy progressive neural network were developed to improve the accuracy of a five-hole probe in measuring large-angle flows. By modifying the denominator and numerator of traditional calibration coefficients, the novel coefficients can solve the singularity and multi-value problems of large-angle flow measurement. By training the neural network using both global calibration data and the calibration data of large measurement error points, the two-stage accuracy progressive neural network can effectively improve the measurement accuracy of a five-hole probe when flow separation occurs around the probe head at large flow angles. The experimental results demonstrate that applying the novel calibration coefficients and accuracy progressive neural network ensures that the calibration error of the flow angle is less than 0.8°, and the flow pressure error is less than 0.1 % when the flow angle reaches 50° at low subsonic speeds.

Assessment of renal perfusion with 82-rubidium PET in patients with normal and abnormal renal function.

Noninvasive measurement of renal blood flow (RBF) and renal vascular resistance (RVR) is challenging, yet critical in renal pathologies. This study evaluates the correlation between serum renal function markers and RBF/RVR assessed using rubidium PET. Dynamic images from 53 patients who underwent rubidium PET for nonrenal indications were analyzed. RBF was determined using a one-compartment model, and RVR was calculated by dividing mean arterial pressure by RBF. The study included 51 patients (31 females and 20 males). Among them, 35 had normal renal function [estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2], and 16 had abnormal renal function (eGFR <60 ml/min/1.73 m2). Patients with normal renal function had significantly higher RBF [median (interquartile range): 443 (297-722) vs 173 (108-380) ml/min/100 g, P = 0.022] and lower RVR [19.1 (12.4-27.2) vs 49.6 (24.4-85.7) mmHg×min×g/ml, P = 0.0011) compared with those with abnormal renal function. There was a moderate correlation between RBF and eGFR (r = 0.62, P < 0.0001) and between RVR and eGFR (r = -0.59, P < 0.0001) in both groups. Among patients with normal renal function, RBF was negatively correlated with age (r = -0.51, P = 0.0017) but there was no correlation among patients with abnormal renal function (r = 0.21, P = 0.44). PET-measured RBF and RVR correlate with renal function markers and differ significantly by renal function status. Further studies are needed to validate rubidium PET's precision and clinical applicability.

Influence of Diabetes Mellitus on Changes in Intra-Operative Decision Making in Coronary Artery Bypass Grafting

Background: We evaluated whether patients with diabetes mellitus experienced more surgical strategy changes than patients without diabetes when undergoing coronary artery bypass graft surgery utilizing a protocol for intraoperative high frequency ultrasound and transit-time flow measurement. Methods: Outcomes of coronary artery bypass grafting (CABG) patients with and without diabetes enrolled in the multicenter prospective Registry for Quality Assessment with Ultrasound Imaging and TTFM in Cardiac Bypass Surgery (REQUEST) study were retrospectively compared. The primary endpoint was frequency of intraoperative surgical strategy changes. We also evaluated the differences in patient characteristics and operative characteristics including graft configuration. Results: We compared 614 non-diabetic patients with 402 diabetic patients, among whom 128 were insulin dependent. Patients with diabetes had higher rates of surgical strategy change for the aortic component of the operation (10.2% vs. 6.4%, odds ratio (OR) = 1.67; 95% confidence interval (CI) = 1.06–2.65; p = 0.026). Surgical strategy changes related to in-situ conduits were more common in on-pump procedures in comparison to off-pump in diabetics (4.0% vs. 0%; p = 0.007). Diabetes was associated with less frequent use of bilateral internal mammary arteries (BIMA) (25.6% vs. 33.7%; p = 0.006), more frequent use of radial artery (31.3% vs. 16.9%; p &lt; 0.001) and multi-arterial configuration (48.3% vs. 39.9%, p = 0.009), and more total grafts (3.1 ± 1.1 vs. 2.8 ± 0.9; p &lt; 0.001). Conclusions: When performing isolated CABG on diabetic patients, surgeons were more likely to change surgical strategy for the aortic component of the operation based on high-frequency ultrasound (HFUS), and more likely to make a change related to in-situ conduits in on-pump procedures in diabetics. Among diabetic patients, there was less frequent use of BIMA, more frequent use of radial artery, more frequent multi-arterial configuration, and more total grafts.

On the utility of partially corrupted flow measurement data arising from adjacent acoustic Doppler current profilers for energy yield assessment

Recommended practice for quantifying the energy resource at a tidal energy site requires the use of multiple instruments deployed across the site. However, the instruments used work by emitting an acoustic pulse and instruments working at the same time have the potential to interfere with each other through a process known as ’cross-talk’. It is important to understand the impact of cross-talk on measurements and how this can be managed and through data processing or suitable positioning of devices. The ReDAPT project conducted a measurement campaign using two Acoustic Doppler Current Profilers (ADCPs) placed upstream of an operational tidal turbine. This aimed to assess the ’in-line’ instrument placement guidelines from IEC 62600-200 for Power Performance Assessment (PPA) in real-world conditions. Consequently, the results within hold potential to support arguments for expanding these zones or adjusting their general dimensions. Despite adhering to industry standards and best practices to eliminate unreliable data in the Quality Control (QC) checks, in both concurrently measuring ADCPs at different time stamps in approximately 15 % of the returned data. This work identified for the first time interference throughout the campaign and quantified subsequent impact on estimates. A method to remove data anomalies caused by interference between closely positioned ADCPs has been developed and demonstrated, resulting in a 7 % variation in estimated Annual Energy Production (AEP). The algorithm effectively removed approximately 90 % of the corrupted measurements. Moving forward, multi-sensor deployments could use the algorithm described to double-check for interference within the data sets, although care should be taken to avoid this by choosing a suitable layout for deployment.

Pathogenesis of Pachyvein Formation in Central Serous Chorioretinopathy: A Hydrodynamic Analysis.

Objectives: To attain an understanding of pachyvein formation seen with central serous chorioretinopathy (CSC) by measuring the choroidal blood flow (CBF) velocity and to apply the findings to existing hydrodynamic theorems. Methods: Nineteen subjects with monocular CSC (mean age 51.8 ± 12.7 years) were included. Laser speckle flowgraphy measured the mean blur rate (MBR) in the foveal and perifoveal regions, and the findings were applied to the Equation of Continuity (Q = AV) and Bernoulli's theorem (1/2V2 + P/ρ = constant). Results: The mean foveal/perifoveal MBRs in the CSC eyes were 6.4 ± 3.2/9.6 ± 3.2 (p < 0.001). The mean MBRs in the non-CSC eyes were 8.3 ± 3.2/7.9 ± 2.4 (p = 0.37). The significant foveal CBF velocity decrease in CSC eyes occurs because of exudation from the hyperpermeable choriocapillaris. The subsequent decrease in blood volume due to the exudation elicits a decrease in the blood flow velocity in the inferior venules in accordance with the Equation of Continuity. The decrease in the blood flow velocity may result in an elevated blood flow pressure in the inferior venules and veins at the exudation site, in accordance with Bernoulli's theorem. Conclusion: A significant decrease in the foveal MBR may result from exudation from the hyperpermeable macular choriocapillaris. This decreased velocity may elicit a blood pressure elevation that can expand the inferior venules and veins at the exudation site, so-called pachyvein and pachychoroid formation. The application of hydrodynamic theorems to the measurement of ocular blood flow can provide new insights into the understanding of the pathogenesis of chorioretinal disease.

Unveiling intricate foam behaviors and dynamic instabilities in a two-phase natural circulation loop with seawater

The use of seawater as an alternative emergency coolant in a nuclear power plant presents great potential to enhance the nuclear safety. The present study investigates the dynamic instabilities during the startup experiments of a natural circulation loop with seawater through synchronization of two-phase flow visualization and measurements of transient fluid flow parameters. The results reveal that in seawater the pressure drop oscillations (PDO) with nature of low-frequency pulse-type loop flow occurs at the modified heat flux of 531.56–654.80 kW/m2. On the other hand, the density wave oscillations (DWO) characterized by high-frequency oscillatory flow prevails at higher modified heat flux of 654.80–1844.46 kW/m2. For the loop with seawater, the flow patterns in the riser may evolve from dispersed bubbly flow, foam flow, foam and short slug flow due to the flashing effects, and foam and long slug flow periodically. The image analysis reveals that the foam fraction may decline from 75% to 52.2%, while the flow pattern transforms from the stage II (foam and cape bubbly flow) to III (foam and long slug flow). On the other hand, the flow pattern may evolve from bubbly flow, cap bubbly flow, turbulent slug flow, and long slug flow in de-ionized water. For DWO, the oscillatory frequency is found to be inlet temperature dependent. Interestingly, both fluids demonstrate identical frequencies of 0.06 Hz, 0.14 Hz, and 0.09 Hz, respectively, corresponding to the inlet temperature range of 40–52 °C, 52–65 °C, and 65–75 °C, despite significantly different evolution of two-phase flow patterns. Indeed, the density wave travels at the same speed through the loop operating at the same power for both seawater and de-ionized water, as the buoyancy force is the primary driving force for the present study. These findings contribute significantly to the better understanding of related industrial processes using seawater as the working fluid.

Reproducibility of a single-volume dynamic CT myocardial blood flow measurement technique: validation in a swine model

BackgroundWe prospectively assessed the reproducibility of a novel low-dose single-volume dynamic computed tomography (CT) myocardial blood flow measurement technique.MethodsThirty-four pairs of measurements were made under rest and stress conditions in 13 swine (54.3 ± 12.3 kg). One or two acquisition pairs were acquired in each animal with a 10-min delay between each pair. Contrast (370 mgI/mL; 0.5 mL/kg) and a diluted contrast/saline chaser (0.5 mL/kg; 30:70 contrast/saline) were injected peripherally at 5 mL/s, followed by bolus tracking and acquisition of a single volume scan (100 kVp; 200 mA) with a 320-slice CT scanner. Bolus tracking and single volume scan data were used to derive perfusion in mL/min/g using a first-pass analysis model; the coronary perfusion territories of the left anterior descending (LAD), left circumflex (LCx), and right coronary artery (RCA) were automatically assigned using a previously validated minimum-cost path technique. The reproducibility of CT myocardial perfusion measurement within the LAD, LCx, RCA, and the whole myocardium was assessed via regression analysis. The average CT dose index (CTDI) of perfusion measurement was recorded.ResultsThe repeated first (Pmyo1) and second (Pmyo2) single-volume CT perfusion measurements were related by Pmyo2 = 1.01Pmyo1 − 0.03(ρ = 0.96; RMSE = 0.08 mL/min/g; RMSE = 0.07 mL/min/g) for the whole myocardium, and by Preg2 = 0.86Preg1 + 0.13(ρ = 0.87; RMSE = 0.31 mL/min/g; RMSE = 0.29 mL/min/g) for the LAD, LCx, and RCA perfusion territories. The average CTDI of the single-volume CT perfusion measurement was 10.5 mGy.ConclusionThe single-volume CT blood flow measurement technique provides reproducible low-dose myocardial perfusion measurement using only bolus tracking data and a single whole-heart volume scan.Relevance statementThe single-volume CT blood flow measurement technique is a noninvasive tool that reproducibly measures myocardial perfusion and provides coronary CT angiograms, allowing for simultaneous anatomic-physiologic assessment of myocardial ischemia.Key PointsA low-dose single-volume dynamic CT myocardial blood flow measurement technique is reproducible.Motion misregistration artifacts are eliminated using a single-volume CT perfusion technique.This technique enables combined anatomic-physiologic assessment of coronary artery disease.Graphical

Research on dynamicflow rate self-sensing in control valves

In the field of control valves of nuclear energy, the measurement and control of the flow rate are widely concerned. Applying the traditional differential pressure flowmeter to directly measure the flow rate of the control valve would lead to unnecessary pressure drop, excessive energy consumption of the pump and high cost, and the obtained flow rate is mainly steady flow rate. In this paper, a self-sensing method of the dynamic flow rate of the control valve is proposed with the advantages of no flowmeter, no need to add moving parts. The original control valve in the pipeline system is used to measure the flow rate, which would not cause additional pressure and energy loss. The self-sensing model of the dynamic flow rate of the control valve is established, and the measurement of the dynamic flow rate is converted into the measurement of the dynamic pressure. The feasibility of the self-sensing model is verified by the experiment on the flow measurement experimental platform. The self-sensing performance of the dynamic flow rate under valve's various working conditions is sufficiently analyzed. Moreover, the self-sensing model is modified and optimized based on the Isight platform. The results show that by introducing the correction coefficient, the maximum relative error after optimization between the self-sensing flow rate and set value is reduced from 11% to 6% under the random movement condition of the valve plug, which enhances the self-sensing ability of the dynamic flow rate.

Utility of an Instantaneous Salt Dilution Method for Measuring Streamflow in Headwater Streams.

Streamflow records are biased toward large streams and rivers, yet small headwater streams are often the focus of ecological research in response to climate change. Conventional flow measurement instruments such as acoustic Doppler velocimeters (ADVs) do not perform well during low-flow conditions in small streams, truncating the development of rating curves during critical baseflow conditions dominated by groundwater inflow. We revisited an instantaneous solute tracer injection method as an alternative to ADVs based on paired measurements to compare their precision, efficiency, and feasibility within headwater streams across a range of flow conditions. We show that the precision of discharge measurements using salt dilution by slug injection and ADV methods were comparable overall, but salt dilution was more precise during the lowest flows and required less time to implement. Often, headwater streams were at or below the depth threshold where ADV measurements could even be attempted and transects were complicated by coarse bed material and cobbles. We discuss the methodological benefits and limitations of salt dilution by slug injection and conclude that the method could facilitate a proliferation of streamflow observation across headwater stream networks that are highly undersampled compared to larger streams.

Signal processing method of ultrasonic gas flowmeter based on transit-time mathematical characteristics

To address the issue of timing errors caused by attenuation and jitter in the echo signal with the conventional threshold method, this paper presents a signal processing method for ultrasonic gas flow meters based on the mathematical characteristics of transit time. First, an improved weighted recursive filtering algorithm based on the mathematical characteristics of transit time is proposed. Then,based on the aforementioned filtering algorithm, a feedback-type threshold adjustment method has been proposed. Finally, the results for the flow meter meeting the performance criteria for a Class 1 accuracy ultrasonic gas flow meter at range of 2∼300 m3/h. This signal processing technique can be implemented at comparatively low cost on existing conventional fixed-threshold flow measurement infrastructures, with the potential to significantly improve accuracy and reliability.

Dry Powder Inhaler Use in Primary School Aged Children with Asthma: A Systematic Review

ObjectiveAsthma is the most common chronic disease in children. Dry powder inhalers (DPI) are effective for medication delivery in adults and adolescents, and provide a lower environmental footprint and more portability when compared to metered dose inhaler (MDI) with spacer. They require specific technique, and it is necessary to ascertain whether they can be used in younger age groups. We aimed to assess evidence regarding whether primary school aged (5–11 years) children can use DPI with adequate technique both during stable and acute asthma.DesignOvid MEDLINE, Embase and PubMed were searched for studies assessing DPI use in children aged 5–11 years with asthma or wheeze. Results of studies were synthesised by study design and outcome measure.ResultsThirty-eight studies were identified for analysis. These were analysed in three groups: (1) 25 studies assessing children's ability to use DPI by peak inspiratory flow measurement, (2) 10 studies assessing children's ability to use DPI by physician assessment, and (3) three studies measuring efficacy of DPI compared to gold standard (MDI with spacer). Five studies included children during acute exacerbations.ConclusionThe majority of primary school aged children have the ability to use a DPI with adequate training, support and practice. Some younger children may have difficulties, and clinician assessment and ongoing review is crucial in determining which children are likely to benefit from a DPI. Consistent correct use and adherence remains a challenge, but this is also an issue with MDI plus spacer and does not appear to be significantly worse with DPI. Evidence of the use of DPI during acute illness is limited, and more studies are required in this setting.

Development of a pump-jet piezoelectric swimmer with acoustic radiation actuation

The acoustofluidic actuation produced by piezoelectric transducer is capable of propelling micro underwater robots forward, yet the motion pattern is relatively simplistic. To solve this problem, a pump-jet swimmer with a combination of the underwater acoustic radiation effect is proposed in this work. The absorption and discharge of internal piezoelectric pump provide the linear forward power, and turning is achieved under the acoustic propulsive force of the external dual piezoelectric actuators. The working mode and optimal driving frequency of the piezoelectric actuators are determined through finite element simulation and mechanical vibration characteristic tests. And the key dimensional parameters of the piezoelectric pump are optimized in the light of the output flow measurements. Finally, a prototype with the size of Ф3.1 cm × 12 cm is fabricated for underwater driving performance experiments, which demonstrated well functions in straight swimming, turning, and loading. The swimmer with 20 g of additional load achieves a maximum speed of 105 mm s−1at the voltage of 180 Vp-p, it also completes the obstacle avoidance in water along a certain path. The rationality of this conceived actuation mechanism is preliminarily verified, which shows a potential for fixed-point transportation in the complex underwater situations.

In-depth Clinical, Hemodynamic, and Volumetric Assessment of the Resection and Partial Liver Transplantation With Delayed Total Hepatectomy-Type Auxiliary Liver Transplantation in Noncirrhotic Setting: Are We Simply Dealing With a Transplant Model of Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy?

The Resection And Partial Liver Transplantation with Delayed total hepatectomy (RAPID) procedure involves left hepatectomy with orthotopic implantation of a left lobe and right portal vein ligation. This technique induces volumetric graft increase, allowing for a right completion hepatectomy within 15 days. Notably, there is a lack of data on the hemodynamics of small-for-size grafts exposed to portal overflow without triggering small-for-size syndrome. A prospective single-center protocol included 8 living donors and 8 RAPID noncirrhotic recipients. Comprehensive clinical and biological data were collected, accompanied by intraoperative arterial and portal flow and pressure measurements. Early kinetic growth rate (eKGR%) and graft function were assessed using computed tomography and 99Tc-mebrofenin scintigraphy on postoperative days 7 and 14. Findings were compared with retrospective data from 13 left living donor liver transplantation (LDLT) recipients. The median Graft-body weight ratio was 0.41% (interquartile range: 0.34-0.49), markedly lower than in LDLT. However, there was no significant difference in eKGR between RAPID and LDLT grafts. Sequential analysis revealed variable eKGR per day: 10.6% (7.8-13.2) in the first week and 7.6% (6-9.1) in the second week posttransplantation. Indexed portal flow (indexed portal vein flow) was significantly higher in RAPID compared with left LDLT ( P = 0.01). No hemodynamic parameters were found to correlate with regeneration speed. We modulated portal flow in 2 out of 8 cases. This study presents the first report of hemodynamic and volumetric data for the RAPID technique. Despite initial graft volumes falling below conventional LDLT recommendations, the study highlights acceptable clinical outcomes.

Kidney Blood Flow and Renin-Angiotensin-Aldosterone System Measurements Associated With Kidney and Cardiovascular Dysfunction in Pediatric Shock.

Pediatric acute kidney injury (AKI) is a prevalent and morbid complication of shock. Its pathogenesis and early identification remain elusive. We aim to determine whether renal blood flow (RBF) measurements by point-of-care ultrasound (POCUS) and renin-angiotensin-aldosterone system (RAAS) hormones in pediatric shock associate with vasoactive requirements and AKI. This is a single-center prospective, noninterventional observational cohort study in one tertiary PICU in North American from 2020 to 2022 that enrolled children younger than 18 years with shock without preexisting end-stage renal disease. RBF was measured by POCUS on hospital days 1 and 3 and plasma RAAS hormone levels were measured on day 1. The primary outcome was the presence of AKI by Kidney Disease Improving Global Outcomes criteria at first ultrasound with key secondary outcomes of creatinine, blood urea nitrogen (BUN), Vasoactive-Inotrope Score (VIS), and norepinephrine equivalent dosing (NED) 48 hours after first ultrasound. Fifty patients were recruited (20 with AKI, mean age 10.5 yr, 48% female). POCUS RBF showed lower qualitative blood flow (power Doppler ultrasound [PDU] score) and higher regional vascular resistance (renal resistive index [RRI]) in children with AKI (p = 0.017 and p = 0.0007). Renin and aldosterone levels were higher in the AKI cohort (p = 0.003 and p = 0.007). Admission RRI and PDU associated with higher day 3 VIS and NED after adjusting for age, day 1 VIS, and RAAS hormones. Admission renin associated with higher day 3 creatinine and BUN after adjusting for age, day 1 VIS, and the ultrasound parameters. In pediatric shock, kidney blood flow was abnormal and renin and aldosterone were elevated in those with AKI. Kidney blood flow abnormalities are independently associated with future cardiovascular dysfunction; renin elevations are independently associated with future kidney dysfunction. Kidney blood flow by POCUS may identify children who will have persistent as opposed to resolving AKI. RAAS perturbations may drive AKI in pediatric shock.

Experimental Study of High-Diodicity Inlet Effects On Rotating Detonation Combustor Performance and Operability

Abstract Implementing high-diodicity inlets is critical to reduce backflow and mitigate the pressure loss across the injector in RDCs. Experiments on air injection diodicity were conducted in a non-premixed RDC for both cold-flow and reacting conditions. The introduction of a Tesla-like diode impacted operating modes and injector dynamics, but the extent of that effect depended on the throat-to-combustor area ratio. A smaller ratio mitigated the impact of the diode on detonation characteristics, while a larger ratio extended the operating range of stronger wave modes. The diode stabilized RDC operation through an increased static pressure drop, but limited performance most likely due to poor reactant mixing and local equivalence ratio distribution. Cold-flow tests showed a higher diodicity for the diode, which may contribute to higher pressure gain in reacting experiments. A modified diodicity formulation based on reacting flow measurements was introduced, suggesting that a multi-metric approach can be useful to assess injector performance. High-diodicity air inlets could be useful tools for reducing total pressure loss and controlling operating modes, but careful consideration is required to limit adverse effects on processes like reactant mixing.

Sap Flow Analyzer: A tool to standardize sap flow estimation and scaling to whole‐tree water use using the HFD method

Abstract Sap flow measurements are fundamental to understanding water use in trees and could aid in predicting climate change effects on forest function. Deriving knowledge from such measurements requires empirical calibrations and upscaling methods to translate thermometric recordings to tree water use. Here, we developed a user‐friendly open‐source application, the Sap Flow Analyzer (SFA), which estimates sap flow rates and tree water use from the heat field deformation (HFD) instruments. The SFA incorporates four key features to ensure maximum accuracy and reproducibility of sap flow estimates: diagnosis diagrams to assess data patterns visually, regression models implemented to increase accuracy when estimating K (the main HFD parameter), three approaches to upscale sap flow rates to whole‐tree water use and visualization of the input parameters' uncertainty. Thirteen participants were given three raw datasets and assigned data processing tasks using the SFA user guide, from estimating sapwood depth to scaling sap flow rates to whole‐tree water use to assess the reproducibility and applicability of the SFA. Participants' results were reasonably consistent and independent of their background in using the SFA, R, or HFD method. The results showed lower variability for high flow rates (SD: mean 1% vs. 10%). K estimates and sapwood depth differentiation were the primary sources of variability, which in turn was mainly caused by the user's chosen scaling method. The SFA provides an easy way to visualize and process sap flow and tree water use data from HFD measurements. It is the first free and open software tool for HFD users. The ability to trace analysis steps ensures reproducibility, increasing transparency and consistency in data processing. Developing tools such as the SFA and masked trials are essential for more precise workflows and improved quality and comparability of HFD sap flow datasets.