Field evidence indicates that only a few large fractures in enhanced geothermal systems (EGS) may dominate fluid flow and lead to the development of thermal short-circuiting. This problem would worsen in heat harvesting through horizontal wells with abundant fractures (induced or natural ones). To limit flow shortcuts that may cause early thermal breakthroughs, we propose a temperature-sensitive flow management system and explore its potential benefits during the development of EGS in horizontal wells. The proposed downhole flow management system consists of sensors for real-time temperature monitoring, and flow control devices for adjusting injection distribution in the wellbore. We evaluate the performance of such systems over 50 years of operation by numerical analysis. The results indicate that, when the proposed system is utilized, the produced fluid temperature will be increased by up to 60 K for a field-scale example. Besides, the application of the proposed flow management system can increase the cumulative heat extraction by up to 48.25 % (0.69 × 1016 J) after 50 years. The heat extraction efficiency can be improved by up to 94.16 %. During the EGS operation, it is suggested to implement multi-stage fluid control, but it is not recommended to reopen the fluid injection that has been previously shut down. Finally, the flow management system can mitigate the negative impacts of geological heterogeneities or the heterogeneity in fracture hydraulic conductivities. This paper proposes a new concept of flow management to integrate horizontal wells into efficient EGSs for power generation and heat extraction in the future.