Cerebral autoregulation maintains adequate cerebral perfusion over varying systemic blood pressures, with any dysfunction giving opportunity for cerebral insult. African American (AA) males experience higher prevalences of hypertension and cerebrovascular abnormalities than their Caucasian (CAUC) counterparts. Potential racial differences in cerebral autoregulation may contribute to the high incidences of cerebrovascular events suffered by AA males. Therefore, the purpose of this investigation was to determine cerebral autoregulation and flow velocities of the cerebral circulation in AA and CAUC males. Cross‐sectional data of beat‐by‐beat blood pressure (BP), end‐tidal CO2 (ETCO2) middle cerebral artery (MCA) and anterior cerebral artery (ACA) velocities, cerebrovascular reactivity (CVR), and cerebral autoregulation was determined at the very low frequency (VLF: 0.03–0.07 Hz) and low frequency (LF: 0.07–0.15 Hz) domains in sample of AA (n=30, 44.91 ± 12.04 years) and CAUC (n=51, 44.48 ± 12.71 years, p=0.879) males. Mean BP was higher in AAs (96.25 ± 14.34 mmHg) than CAUCs (88.39 ± 11.93 mmHg, p=0.015). Systolic BP was elevated in AAs (137.64 ± 20.39 mmHg) compared to CAUCs (128.52 ± 16.65, p=0.037), with the same trend seen with diastolic BP (AA: 77.53 ± 12.81 mmHg; CAUC: 70.49 ± 11.31 mmHg, p=0.021). ETCO2 and CVR was comparable between groups (p=0.351 and p=0.290, respectively). Cerebral autoregulation was similar between groups in the MCA at the VLF (Coherence: p=0.184, Gain: p= 0.748, Phase: p=0.841) and LF (Coherence: p=0.683, Gain: p=0.800, Phase: p=0.178) domains. Cerebral autoregulation was also proportionate in the ACA at the VLF (Coherence: p=0.360, Gain: p=0.266, Phase: p=0.231) and LF (Coherence: p=0.293, Gain: p=0.530, Phase: p=0.360) domain. Autoregulation index at the MCA and ACA was comparable between groups (p=0.358 and p=0.620, respectively). MCA mean flow velocity was similar between groups (p=0.814), although ACA mean flow velocity was higher in AAs (52.17 ± 8.89 ml/cm/s) compared to CAUCs (44.02 ± 11.19 ml/cm/s, p=0.013). The current data demonstrate comparable levels of cerebral autoregulation in AA and CAUC males, despite differing systemic BP and ACA velocities. This proposes that cerebral autoregulation is intact within AA males and may not contribute to the increased prevalence of cerebrovascular insults shown in current epidemiological data. Future studies are warranted to include larger sample sizes in addition to absolute cerebral blood flow measures to confirm these findings.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.