Abstract Due to the excellent compatibility of VPX in the international aerospace embedded specifications, VPX specifications are often employed in the design of payload processors for space applications. This paper introduces the design features of a 3U hot-swappable chassis based on the VPX specification, focusing on overall layout and thermal design. To fully utilize the performance of the VPX platform, a modular design is adopted in the overall layout, allowing different functional modules to be freely combined to meet various requirements. The chassis reserves a position for a computing module, facilitating future expansions. In the thermal design, considering the high-density modules inside the chassis, heat pipes are employed to rapidly transfer heat to the chassis rails and outer shell, enhancing the overall heat dissipation capability. Thermal simulation analysis using FLOTHERM software validates that the optimized thermal design meets the first-level derating standards for spacecraft. The finite element analysis results show that the fundamental frequency of the entire machine is 215 Hz, and all indicators meet the design requirements.