Many years of experience in preserving species of Siberian flora listed in the Red Data Books of Russia in 2008 and 2023 are analyzed. In total, since 1947, 21 species from 13 families, the geographical points of origin of which are located mainly in Southern Siberia, have been tested on the territory of the botanical and geographical exhibition in the laboratory of natural flora of the GBS RAS. According to the degree of introduction resistance, 90% of species are resistant, weakly resistant and unstable - 10%. In terms of life expectancy under exposure conditions, species growing for more than 20 years predominate - 47.6%. The minimum lifespan of Oxytropis nitens is 2 years. The maximum life expectancy was reached by: Paeonia hybrida - 63 years, Anemonastrum baikalense - 53 years, Erythronium sibiricum - 50 years. The reliability and prospects of preserving rare species of Siberia in the conditions of Moscow are shown.