This article aims to examine and understand the current scope of Prescriptive Maintenance integrated with the human-centric characteristics of Industry 5.0. Therefore, the main research question is the following: “In the view of the managers of the companies visited, located in the Southeast Region of Brazil, what are the main technical and administrative difficulties that companies encounter in successfully implementing proactive combinations on the factory floor, such as Prescriptive Maintenance integrated with the characteristics of Industry 5.0”?. The evolution of industrial processes in recent decades and the advent of Industry 4.0 integrated with human-centered characteristics have placed maintenance as one of the protagonists of industrial processes. In a scenario where automation and humans are gaining more and more space, the future of industries lies in Prescriptive Maintenance. To achieve the objective of the article, professional experiences from participation in congresses, seminars and technical visits to several factories located in the Southeast Region of Brazil are used. In data collection, we explored documentary observation and bibliographic research in the Science Direct and Web of Science databases. The study focuses on research areas related to maintenance integration, Industry 4.0 (Techno centric) and human-centric characteristics (Industry 5.0). The article brought important conclusions, as it addresses the impact and trends on the factory floor so that managers can develop competitiveness and productivity. The article highlights the role of maintenance methods in improving factory floor performance, emphasizing human knowledge and Prescriptive Maintenance practices to ensure operations within World Class standards.