Arid ecohydrology relies on sporadic rainfall and flooding to sustain linear river oases, crucial for supporting flora and fauna during the long dry season and drought years. Growing water demands have led to large reservoir constructions, severely impacting the fragile arid ecosystems. We analyse the hydro-geomorphological impacts of the large Neckartal Dam (completed in 2019) on the Fish River oasis based on existing dams, regional studies, field surveys, hydrological data, and modelling. The Neckartal Dam, along with three smaller dams, impounds 80 % of the desert oasis basin (1235 Mm3, 55,870 km2), exceeding the average annual runoff threefold. A gradient of dam-induced changes was identified, varying with distance from the dam wall. Immediate downstream, hydromorphological impacts include channel narrowing (⁓15 %) and reduce mean annual sediment yield (⁓20 %). Also, water distribution losses create chronic low flows, favour for invasive flora and fauna to spread, significantly disrupting the pristine nature of the desert ecosystem. This phenomenon has been observed over a 70 km stretch below the Hardap Dam. This situation is irreversible, as the invasive flora can withstand even large floods. As the distance increases, the dam suppresses low to moderate annual floods and prolongs droughts from months to years or even decades. Based on our flood routing model, only the largest floods (recurrence interval, RI >25 years) can exceed the dam storage, continue downstream, transport sediment and maintain the pool-bar morphology along 245 km of the oasis. The lack of significant flows between major floods means that sediment from smaller, lower arid basins accumulates in the Fish River valley, filling pools and further reducing water availability during dry periods. The Neckartal Dam's impact assessment demonstrates potential changes in arid river systems globally.