Flexion Axis Research Articles

Investigation of Characteristic Motion Patterns of the Knee Joint During a Weightbearing Flexion.

This study aimed to develop and validate a novel flexion axis concept by calculating the points on femoral condyles that could maintain constant heights during knee flexion. Twenty-two knees of 22 healthy subjects were investigated when performing a weightbearing single leg lunge. The knee positions were captured using a validated dual fluoroscopic image system. The points on sagittal planes of the femoral condyles that had minimal changes in heights from the tibial plane along the flexion path were calculated. It was found that the points do formulate a medial-lateral flexion axis that was defined as the iso-height axis (IHA). The six degrees of freedom (6DOF) kinematics data calculated using the IHA were compared with those calculated using the conventional transepicondylar axis and geometrical center axis. The IHA measured minimal changes in proximal-distal translations and varus-valgus rotations along the flexion path, indicating that the IHA may have interesting clinical implications. Therefore, identifying the IHA could provide an alternative physiological reference for improvement of contemporary knee surgeries, such as ligament reconstruction and knee replacement surgeries that are aimed to reproduce normal knee kinematics and medial/lateral soft tissue tensions during knee flexion.

Interpretation of natural tibio-femoral kinematics critically depends upon the kinematic analysis approach: A survey and comparison of methodologies

While there is general agreement on the transverse plane knee joint motion for loaded flexion activities, its kinematics during functional movements such as level walking are discussed more controversially. One possible cause of this controversy could originate from the interpretation of kinematics based on different analysis approaches. In order to understand the impact of these approaches on the interpretation of tibio-femoral motion, a set of dynamic videofluoroscopy data presenting continuous knee bending and complete cycles of walking in ten subjects was analysed using six different kinematic analysis approaches. Use of a functional flexion axis resulted in significantly smaller ranges of condylar translation compared to anatomical axes and contact approaches. All contact points were located significantly more anteriorly than the femur fixed axes after 70° of flexion, but also during the early/mid stance and late swing phases of walking. Overall, a central to medial transverse plane centre of rotation was found for both activities using all six kinematic analysis approaches, although individual subjects exhibited lateral centres of rotation using certain approaches. The results of this study clearly show that deviations from the true functional axis of rotation result in kinematic crosstalk, suggesting that functional axes should be reported in preference to anatomical axes. Contact approaches, on the other hand, can present additional information on the local tibio-femoral contact conditions. To allow a more standardised comparison and interpretation of tibio-femoral kinematics, results should therefore be reported using at least a functionally determined axis and possibly also a contact point approach.

Distal Humeral Trochlear Geometry Associated With the Spatial Variation of the Dynamic Elbow Flexion Axis.

Background: The complexity of the spatial dynamic flexion axis (DFA) of the elbow joint makes the elbow prosthesis design and humeral component alignment challenging. This study aimed to 1) investigate the variations of the spatial DFA during elbow flexion and 2) investigate the relationship between the distal humeral trochlear geometry and the in vivo spatial variation of the DFA. Methods: Ten healthy subjects participated in this study. Each subject performed a full elbow extension to maximum flexion with hand supination under dual fluoroscopic imaging system (DFIS) surveillance. The 2D fluoroscopic images and the 3D bone models were registered to analyze the in vivo elbow kinematics and DFAs. The spatial DFA positions were defined as inclination with the medial and lateral epicondyle axes (MLA) in the transverse and coronal planes. The range of the DFA positions was also investigated during different flexion phases. The Spearman correlation method was used to analyze the relationship between the distal humeral trochlear’s morphological parameters and the position of DFAs during different flexion phases. Results: The pathway of the DFAs showed an irregular pattern and presented individual features. The medial trochlear depth (MTD) (r = 0.68, p = 0.03) was positively correlated with the range of the DFA position (2.8° ± 1.9°) in the coronal plane from full extension to 30° of flexion. Lateral trochlear height (LTH) (r = −0.64, p = 0.04) was negatively correlated with the DFA position (−1.4° ± 3.3°) in the transverse plane from 30° to 60° of flexion. A significant correlation was found between LTH with the DFA position in the coronal (r = −0.77, p = 0.01) and transverse planes (r = −0.76, p = 0.01) from 60° to 90° of flexion. Conclusion: This study showed that the pathway of the dynamic flexion axis has an individual pattern. The medial and lateral trochlear sizes were the key parameters that might affect the elbow joint flexion function. When recovering complex distal humeral fractures or considering the implant design of total elbow arthroplasty, surgeons should pay more attention to the medial and lateral trochlea’s geometry, which may help restore normal elbow kinematics.

Effect of subjective vertical perception on lateral flexion posture of patients with Parkinson\u2019s disease

In a retrospective study we tested our hypothesis that the subjective postural vertical ratio (SPV ratio), i.e., the subjective postural vertical measured in relation to the lateral flexion axis, is predictive of lateral trunk flexion in patients with Parkinson's disease (PD). Twenty-five patients were included. The SPV angle, i.e., the subjective perception of a vertical position with reference to the vertical axis, and the SPV ratio, i.e., the SPV angle with reference to the axis of lateral flexion, were calculated. The SPV ratio (r = 0.698, P = 0.001) and LTF angle (r = − 0.601, P = 0.001) correlated with change in the LTF angle at 1 year. The SPV ratio was significantly smaller in patients for whom lateral trunk flexion improved (n = 12) than in those for whom it did not improve (n = 13) (0.99 ± 0.78 vs 1.66 ± 0.71, P = 0.011). The AUC under the ROC curve of the SPV ratio for discrimination of improvement was 0.795 (95% confidence interval: 0.61–0.98). We found that the SPV ratio is associated with change in the LTF and that it can conceivably be used to predict the likelihood of improvement in PD-associated lateral trunk flexion.

Human-Like Endtip Stiffness Modulation Inspires Dexterous Manipulation With Robotic Hands.

We present a novel method for biomechanically inspired mechanical and control design by quantifying stable manipulation regions in 3D space for tendon-driven systems. Using this method, we present an analysis of the stiffness properties for a human-like index finger and thumb. Although some studies have previously evaluated biomechanical stiffness for grasping and manipulation, no prior works have evaluated the effect of anatomical stiffness parameters throughout the reachable workspace of the index finger or thumb. The passive stiffness model of biomechanically accurate tendon-driven human-like fingers enables analysis of conservatively passive stable regions. The passive stiffness model of the index finger shows that the greatest stiffness ellipsoid volume is aligned to efficiently oppose the anatomical thumb. The thumb model reveals that the greatest stiffness aligns with abduction/adduction near the index finger and shifts to align with the flexion axes for more efficient opposition of the ring or little fingers. Based on these models, biomechanically inspired stiffness controllers that efficiently utilize the underlying stiffness properties while maximizing task criteria can be developed. Trajectory tracking tasks are experimentally tested on the index finger to show the effect of stiffness and stability boundaries on performance.

Investigation of femoral condyle height changes during flexion of the knee: implication to gap balance in TKA surgery.

Gap balance of the knee at 0° and 90° of flexion has been pursued in total knee arthroplasty (TKA) with the trans-epicondyle axis (TEA) as a reference. This study investigated the height changes of the tibiofemoral articulation and compared the data with the femoral condyle height changes measured using different flexion axes. Twenty healthy knees were investigated during an invivo weightbearing flexion using a techniquecombining MRI anda dual fluoroscopic imaging system (DFIS). The tibiofemoral contact points and the femoral condyle heights [measured using: TEA, geometric center axis (GCA), and iso-height axis (IHA)] were determined at each flexion angle. The height changes of the articular contact points and the femoral condyles were compared along the flexion path. The changes of the medial and lateral contact point heights were within 2.5mm along the flexion path. The changes of the medial and lateral condyle heights were within 8.9mm for TEA, within 4.2mm for GCA and within 3.0mm for IHA. The height changes measured by the contact points and IHA are similar (p > 0.05), and both are significantly smaller than those measured using the TEA and GCA (p < 0.05). The TEA and GCA measured varying femoral condyle heights, but the IHA resulted in minimal condyle height changes and could better represent the articulation characteristics of the knee. The data suggested that the IHA could be used as an alternative reference to guide surgical preparation of gap balance along the knee flexion path during TKA surgeries.

A generalized framework for determination of functional musculoskeletal joint coordinate systems

Establishing anatomical coordinate systems (CS) from anatomical landmarks is sensitive to landmark selection. Vastly different results can be obtained amongst observers which can greatly affect the resulting joint kinematics. The aim of this study is to introduce an objective method for calculating functional CS definitions for bones in joints that observe three-cylindrical-joint kinematic chain decomposition methods and to apply the method on tibiofemoral joint specimens. This method is driven by low resistance joint motion during loading profiles and not from anatomical landmark selection. Two anatomical CS definitions were established from points collected by five observers, for twelve knees. The knees underwent passive flexion and internal/external rotation using the anatomical CSs. The kinematics from these profiles were used in linear least squares minimization of off-axis motions to redefine the tibia and femur origins, the femur flexion axis and the tibia internal rotation axis. Significant improvements in reproducibility of 7.4 mm (tibia origin, p < 0.001), 3.4 mm (femur origin, p < 0.001), and 2.9° (femur FE-axis, p < 0.001) between the two functional CSs compared to the two anatomical CSs were observed.Functional CSs led to significant decreases in off-axis motion during discrete passive flexion profiles. This new strategy for establishing functional CSs provides an objective approach that will reduce the effects of observer error in establishing CSs. Additionally, functional CSs allow for better interpretations of kinematic responses due to loading because effects of kinematic cross-talk is minimized.

Physiological articular contact kinematics and morphological femoral condyle translations of the tibiofemoral joint

The changes of tibiofemoral articular cartilage contact locations during knee activities represent a physiological functional characteristic of the knee. However, most studies reported relative motions of the tibia and femur using morphological flexion axes. Few data have been reported on comparisons of morphological femoral condyle motions and physiological tibiofemoral cartilage contact location changes. This study compared the morphological and physiological kinematic measures of 20 knees during an in vivo weightbearing single leg lunge from full extension to 120° of flexion using a combined MRI and dual fluoroscopic imaging system (DFIS) technique. The morphological femoral condyle motion was measured using three flexion axes: trans-epicondylar axis (TEA), geometric center axis (GCA) and iso-height axis (IHA). At low flexion angles, the medial femoral condyle moved anteriorly, opposite to that of the contact points, and was accompanied with a sharp increase in external femoral condyle rotation. At 120° of flexion, the morphological measures of the lateral femoral condyle were more posteriorly positioned than those of the contact locations. The data showed that the morphological measures of femoral condyle translations and axial rotations varied with different flexion axes and did not represent the physiological articular contact kinematics. Biomechanical evaluations of the knee joint motion should include both morphological and physiological kinematics data to accurately demonstrate the functionality of the knee.

The Effect of Correction Algorithms on Knee Kinematics and Kinetics during Gait of Patients with Knee Osteoarthritis.

In gait analysis, the accuracy of knee joint angles and moments is critical for clinical decision-making. The purpose of this study was to determine the efficacy of two existing algorithms for knee joint axis correction under pathological conditions. Gait data from 20 healthy participants and 20 patients with knee osteoarthritis (OA) were collected using a motion capture system. An algorithm based on Principal Component Analysis (PCA) and a functional joint-based algorithm (FJA) were used to define the knee joint flexion axis. The results show that PCA decreased crosstalk for both groups, and FJA reduced crosstalk in patients with knee OA only. PCA decreased the range of motions of patients with knee OA in the direction of abduction/adduction significantly. There was a significant increase in the maximum knee flexion moment of patients with knee OA by FJA. The results indicate that both algorithms can efficiently reduce crosstalk for gait from patients with knee OA, which can further influence the results of knee joint angles and moments. We recommend that the correction algorithms be applied in clinical gait analysis with patients with knee OA.

The Effect of Knee Flexion on Length Changes and Stress Distribution of Ligaments: A Displacement Controlled Finite Element Analysis.

The use of dynamic finite element analysis to investigate the biomechanical behavior of the knee joint is mainly based on movement of the joint. Challenges are associated with simulation of knee joint flexion-extension activity. This study investigated changes in the length and stress state of ligaments during lunge with a displacement controlled finite element analysis of the knee joint based on in vivo fluoroscopic kinematic data. The geometric center axis (GCA) was used to represent knee kinematics to quantify femoral motion relative to the tibia. Because the GCA was considered as a functional flexion axis, 2 degrees of freedom could be reduced. Published data on the in vivo fluoroscopic kinematic features of the GCA were used to establish the equations for degrees of freedom. Data for 4 degrees of freedom were obtained simultaneously at every 5° of knee flexion. Displacement and rotation were applied to the femur and tibia to produce relative displacement, and the elongation and stress state of the knee ligaments were computed. The predictions confirmed that lunge affected the biomechanical behavior of ligaments. Displacement controlled finite element analysis of knee flexion can be simulated on the basis of fluoroscopic kinematic data to achieve physiologic movement. [Orthopedics. 2021;44(1):e61-e67.].

A Cluster-based Model Using Functional Methods Requires Less Operator Experience for Reliable Gait Analysis: A Preliminary Study of Intra- and Inter-assessor Reliability.

Reliability of three-dimensional gait analysis is important for repetitive assessments in clinical or research studies. In this paper, we hypothesized that a Strathclyde Functional Cluster Model (SFCM) in which all the joint centers and flexion axes were determined by functional methods, could improve the reliability of joint kinematics within and between operators' sessions compared to an anatomical model, Plug-in Gait (PiG). A preliminary study of intra- and inter-assessor reliability of the SFCM was been analyzed and compared to the PiG. One able-bodied participant performed eight sessions measured by four operators who have different experience level on the two models. Intra- and inter-operator reliability of the SFCM and PiG were assessed using the intraclass correlation coefficient (ICC) and standard deviation (SD). Results showed that the SFCM generated smaller SD and greater ICC values for all joint variables compared to the PiG in the inter-operator condition, suggesting that functional methods could improve the inter-operator reliability. Moreover, the intra-operator ICC results indicated that the SFCM performance was less influenced by operator experience compared to the PiG. In conclusion, as the model requires less palpation of ALs, it would benefit the users who have less experience in practical use.

A strathclyde cluster model for gait kinematic measurement using functional methods: a study of inter-assessor reliability analysis with comparison to anatomical models

A major source of error in reliability of gait analysis arises from the palpation of anatomical landmarks (ALs). The purpose of this study was to investigate whether less reliance on manually identifying ALs could improve inter-assessor reliability of joint kinematics compared to two anatomical models. It was hypothesised that the Strathclyde functional cluster model (SFCM), in which the hip, knee and ankle joint centres and knee and ankle flexion axes were determined by functional methods, would obtain greater inter-assessor reliability. Ten able-bodied participants and seven assessors were recruited. Each participant completed three trials conducted by different assessors on non-consecutive days. Agreement and inter-assessor reliability between the models were compared and analysed, whilst factor effects of assessor experience and body mass index (BMI) were investigated. The SFCM obtained excellent agreement with anatomical models for all sagittal angles and hip ab/adduction angle, and it showed slightly higher inter-assessor reliability with smaller variations in the knee and ankle. The assessor experience was not a significant factor, but the BMI had a significant effect on the inter-assessor reliability. The results demonstrate that the SFCM may be more beneficial for less experienced assessors.

Sagittal radius of curvature, trochlea design and ultracongruent insert in total knee arthroplasty.

Multi radius (MR) total knee arthroplasty (TKA) has been associated with mid-flexion instability.Single radius (SR) TKA may provide better anteroposterior stability through single flexion axis and biomechanical advantage for quadriceps function.Medial pivot (MP) TKA and gradually reducing (GR) radius TKA produce better knee kinematics.Clinical outcomes are equivalent for SR, MR and MP TKA.Short-term studies have shown better clinical outcomes and kinematics for GR TKA.Thinner and narrow anterior flange, deeper trochlea groove and more anatomical trochlea design reduces patellofemoral complications in TKAUltracongruent inserts provide comparable clinical outcomes to posterior-stabilized TKA and cruciate retaining TKA.Cite this article: EFORT Open Rev 2019;4:519-524. DOI: 10.1302/2058-5241.4.180083

The most appropriate cervical vertebra for the measurement of occipitocervical inclination parameter: a validation study of C3, C4, and C5 levels using multi-positional magnetic resonance imaging.

To evaluate which cervical level is the most appropriate level to measure occipitocervical inclination (OCI). Sixty-two patients with multi-positional MRI: 24 males and 38 females, who had cervical lordosis and had a disk degeneration grade of 3 or less were included. We measured patient's OCI at C3, C4, and C5, occipitocervical angle (OCA), occipitocervical distance (OCD), C2-7 angle, and cervical sagittal vertical axis (cSVA) in neutral, flexion, and extension position. The correlation between OCI and OCA, OCD, C2-7 angle, and cSVA on each cervical level in all three positions was tested using Pearson's correlation coefficient test. The difference between OCIs at each cervical level was tested by Wilcoxon signed-rank test. p value of less than 0.05 was set as a statistically significant level. C5 OCI showed statistically significant correlation with OCA, OCD, C2-7 angle, and cSVA in all three positions (p < 0.05, r = 0.214-0.525). C3 OCI in flexion (p = 0.393, r = 0.081) and C4 OCI in neutral and flexion (neutral p = 0.275, r 0.104; flexion p = 0.987, r = 0.002) did not show significant correlation with C2-7 angle. There was a statistically significant difference between C3, C4, and C5 OCIs in neutral and extension position (p < 0.05). At the same time, OCI showed statistically strong correlation between adjacent cervical levels (p < 0.001, r = 0.627-0.822). C5 cervical level is the most appropriate level for OCI measurement. OCI should be measured at the same cervical level at all time. C4 OCI can reliably substitute C5 OCI in case C5 which is invisible on radiographic image. These slides can be retrieved under Electronic Supplementary Material.

In vitro determination of the passive knee flexion axis: Effects of axis alignment on coupled tibiofemoral motions

The natural passive flexion axis of human cadaveric knees was determined using a technique that minimized coupled tibiofemoral motions (translations and rotations), and the kinematic effects of mal-positioned flexion axes were determined. The femur was clamped in an apparatus that allowed unconstrained tibial motions as the knee was flexed from 0° to 90°. To establish the natural flexion axis, the femur's position was adjusted such that coupled tibiofemoral motions were minimized. Tests were repeated, first with the femur rotated internally and externally from its original position, and again after positioning the femur to flex the knee about the transepicondylar axis. Compared to the transepicondylar axis, flexion about the natural axis significantly reduced mean tibial translation by 66.4% (p < 0.01) and varus–valgus rotation by 70.1% (p <0.01). Mean varus–valgus rotation increased by 3.4° (factor of 4) when the femur was rotated 3° internally or externally from the optimum position. Differences in condylar location coordinates between the transepicondylar and natural flexion axes most likely indistinguishable clinically. Knee flexion about an axis that minimizes coupled tibiofemoral motions could be important for placement and orientation of a femoral total knee component and for specimen alignment during biomechanical knee testing.

Effects of realistic sheep elbow kinematics in inverse dynamic simulation.

Looking for new opportunities in mechanical design, we are interested in studying the kinematic behaviour of biological joints. The real kinematic behaviour of the elbow of quadruped animals (which is submitted to high mechanical stresses in comparison with bipeds) remains unexplored. The sheep elbow joint was chosen because of its similarity with a revolute joint. The main objective of this study is to estimate the effects of elbow simplifications on the prediction of joint reaction forces in inverse dynamic simulations. Rigid motions between humerus and radius-ulna were registered during full flexion-extension gestures on five cadaveric specimens. The experiments were initially conducted with fresh specimens with ligaments and repeated after removal of all soft tissue, including cartilage. A digital image correlation system was used for tracking optical markers fixed on the bones. The geometry of the specimens was digitized using a 3D optical scanner. Then, the instantaneous helical axis of the joint was computed for each acquisition time. Finally, an OpenSim musculoskeletal model of the sheep forelimb was used to quantify effects of elbow joint approximations on the prediction of joint reaction forces. The motion analysis showed that only the medial-lateral translation is sufficiently large regarding the measuring uncertainty of the experiments. This translation assimilates the sheep elbow to a screw joint instead of a revolute joint. In comparison with fresh specimens, the experiments conducted with dry bone specimens (bones without soft tissue) provided different kinematic behaviour. From the results of our inverse dynamic simulations, it was noticed that the inclusion of the medial-lateral translation to the model made up with the mean flexion axis does not affect the predicted joint reaction forces. A geometrical difference between the axis of the best fitting cylinder and the mean flexion axis (derived from the motion analysis) of fresh specimens was highlighted. This geometrical difference impacts slightly the prediction of joint reactions.

Does medial-to-lateral femoral posterior condylar offset difference effect accuracy of established reference axes for determining femoral component rotation in total knee arthroplasty?

Aims and Objectives: The femoral posterior condylar offset (PCO) has been viewed with increased significance for knee joint movement patterns and has been discussed for its possible implication for femoral component rotation in total knee arthroplasty (TKA). However, a great inter-individual variability in medial and lateral PCO size has also been demonstrated. Though the medial and lateral PCO seem closely related to the functional flexion axis (fFA), determined by the radius curvature of the medial and lateral femoral condyle, the relationship of both parameters considering their impact on the accuracy of established reference axes for determining femoral component rotation in TKA remains unknown. The objective of this paper was, therefore, to compare the individual fFA with the anatomical and surgical transepicondylar axis (aTEA; sTEA) and with the posterior condylar axis (PCA) considering the medial and lateral PCO size. It was hypothesized that the disparity of the PCO influences the accuracy of the sTEA, aTEA, and PCA for determination of femoral component rotation in TKA. Materials and Methods: MRI investigations of 56 consecutive non-arthritic knee joints (male/female 28/28; mean age 22.8 years; range 16-59 years) were used for this study. Coronal, sagittal and transverse MRI images were used to measure the medial and lateral PCO and to determine the fFA, aTEA, sTEA, and PCA for each subject as described previously. A paired two-tailed t-test was used to test for differences between the medial and lateral PCO sizes. Deviation of the aTEA, sTEA and PCA from the fFA were analyzed with a one-sample t-test. Correlation analysis (Pearson r) was used to determine the relationship between the PCO ratio (medial-to-lateral PCO) and the deviation of the aTEA, sTEA and PCA from the fFA in each subject. The level of significance was set at 0.05. Results: The mean medial PCO was 34.0 mm (90%CI 28.72-30.55 mm; range 26.3 to 44.7 mm) and the lateral PCO averaged 29.64 mm (90%CI 30.3-31.4 mm; range 14.3 to 39.1 mm) (p<0.0001). The medial-to-lateral PCO ratio was 1.16 (90%CI 1.13 -1.19; range 0.93 to 1.85). The aTEA showed an increased external rotation in relation to the fFA throughout the whole PCO ratio range (mean deviation 4.2°; 95%CI 3.8°-4.6°; range -4.2° to 10.1°; p<0.0001), whereas the sTEA tends towards a slight but significant internal rotation throughout the PCO ratio range (mean deviation -1.6°; 95%CI -2.1°- -1.2°; range -8.1° to 4.8°; p<0.0001). The PCA showed the best conformity with the fFA (mean difference -0.2°; 95%CI -0.5°-0.2°; range -6° to 5.3°; p=0.36) and was most robust against medial-to-lateral PCO variations. A weak but significant positive correlation between the PCO ratio and the deviation from the fFA was solely found for the sTEA (r=0.28; p=0.042). Conclusion: Differences of the medial and lateral PCO size are a common finding. The PCA had the best match with the fFA, regardless of medial-to-lateral PCO disparity. Only the sTEA was influenced to a small extent by variation of the PCO-ratio.

Sagittal flexion arc evaluation for a modern generation single-radius femoral component design.

Single-radius femoral total knee design aims to deliver improved kinematic behaviour when compared to the standard two-radii geometry. This study has evaluated the behaviour, through a functional range of motion in the sagittal plane, of a single-radius femoral component compared to a dual-radius standard knee construct. Particular focus was placed on how the flexion axes of the native and replaced knee approximated to the transepicondylar axis through a loaded navigated knee design. Significant differences in flexion arcs were noted between the native and total knee arthroplasty state. These arcs were not uniform in all knees and did not display single-radius behaviour. There were no significant differences in the location of flexion axes in the native and total knee arthroplasty knee. Both exhibited similar posterior and inferior transverse axes of motion with respect to the anatomical epicondylar axis. This work has cast doubt on the reliability under loaded conditions of the single-radius concept, but the close proximity of the flexion axes of each replaced knee in relation to the functional flexion axis of the native knee may be the true basis of this purported improved kinematic performance.

Chapter 2 - Chiari 1 deformity in children: etiopathogenesis and radiologic diagnosis

The metamerically associated normal hindbrain and normal posterior fossa are programmed to grow together in such a way that the tonsils are located above the foramen magnum and surrounded by the cerebrospinal fluid (CSF) of the cisterna magna. This allows the pulsating CSF to move freely up and down across the craniovertebral junction (CVJ). A developmental mismatch between the rates of growth of the neural tissue and of the bony posterior fossa may result in the cerebellar tonsils being dislocated across the foramen magnum. The cause of this may be, rarely, an overgrowth of the cerebellum. More commonly, it is due to an insufficient development of the posterior fossa, possibly associated with a malformation of the craniocervical joint. When it is not due to a remediable cause, such a herniation is called a Chiari 1 deformity. This definition is anatomic (descent of the tonsils below the plane of the foramen magnum) and not clinical: many patients with the deformity are and will remain asymptomatic. Most authors consider that a descent of 5 mm or more is clinically significant but other factors, such as the diameter of the foramen magnum and the degree of tapering of the upper cervical "funnel," are likely to be as important. Morphologic markers of severity on magnetic resonance imaging are, beside the degree of descent, the peg-like deformity of the tonsils, the obstruction of the surrounding CSF spaces (at the craniocervical junction and in the whole posterior fossa), a compression of the cord, an abnormal signal of the cord, and a syringomyelia, typically cervicothoracic. The syringomyelia is assumed to be explained by the "Venturi effect" that is associated with the increased velocity of the CSF across the restricted CSF spaces. Radiologically, the etiopathogenic assessment should address the size and morphology of the posterior fossa, and the functional status of the craniocervical flexion joint. The posterior fossa is best evaluated on sagittal cuts by the posterior fossa pentagon proportionality associated with the line of Chamberlain, and on coronal cuts, by showing a possible shallowness of the posterior fossa. The functional status of the craniocervical joint is altered in case of a proatlantal hypoplasia, as this condition results in a cranial shift of the joint that brings the tip of the dens and of the flexion axis in front of the medulla, that is, in a situation of osteoneural conflict. Less commonly, similar conflicts may also occur when an abnormal craniocervical segmentation results in an instability of the joint.

MRI kinematic analysis of T1 sagittal motion between cervical flexion and extension positions in 145 patients.

Although the T1 vertebra is considered as an important factor of cervical balance, little is known about its motion between flexion and extension. The purpose of present study was to analyze the T1 sagittal motion using kinematic magnetic resonance imaging (kMRI), and to identify factors that relate to T1 sagittal motion. We retrospectively analyzed 145 kMR images taken in weight-bearing neutral, flexion and extension positions. Cervical balance parameters were evaluated in each position. The degree of T1 sagittal motion was defined as [(T1 slope at extension) - (T1 slope at flexion)]. All patients were divided into three groups: Positive group (T1 followed the head motion, T1 sagittal motion>5°), Stable group (5≥,≥- 5) and Negative group (T1 moved in the opposite direction from the head motion,>-5). The groups were compared and multivariate logistic regression analysis was calculated. There were 57 (40%) patients in the positive, 56 (39%) in the stable and 32 (22%) in the negative group. The positive group had the largest C2-7 sagittal vertical axis in flexion (p<0.001) and the shortest in the extension (p=0.023). Similar trends were seen in cranial tilt and cervical tilt. The value of T1 height<27mm was a significant independent factor for the negative group (p=0.008, adjusted odds ratio=5.958). Based on T1 sagittal motion, 40% of the patients were classified in positive group (the T1 vertebra followed the head motion in flexion and extension), and 20% were classified in the negative group (the T1 vertebra moved in the opposite direction from the head motion). T1 height<27mm was a potential predictor of negative group.