In this paper, a coupled smoothed finite element method (S-FEM) is developed to deal with the structural-acoustic problems consisting of a shell configuration interacting with the fluid medium. Three-node triangular elements and four-node tetrahedral elements that can be generated automatically for any complicated geometries are adopted to discretize the problem domain. A gradient smoothing technique (GST) is introduced to perform the strain smoothing operation. The discretized system equations are obtained using the smoothed Galerkin weakform, and the numerical integration is applied over the further formed edge-based and face-based smoothing domains, respectively. To extend the edge-based smoothing operation from plate structure to shell structure, an edge coordinate system is defined local on the edges of the triangular element. Numerical examples of a cylinder cavity attached to a flexible shell and an automobile passenger compartment have been conducted to illustrate the effectiveness and accuracy of the coupled S-FEM for structural-acoustic problems.