Sphaeranthus indicus Linn., belonging to the Asteraceae family, It thrives abundantly in damp areas, including as a weed in rice fields across India. In traditional Indian medicine, many different components of the plant, including the leaves, cortex, wood, roots, flower, and seed, are used to cure a variety of illnesses. Astringent, stomachic, refreshing, and externally calming are some of the qualities associated with the herb. Sphaeranthus indicus is rich in diverse secondary metabolites, including eudesmanolides, sesquiterpenoids, sesquiterpene lactones, sesquiterpene acids, flavone glycosides, flavonoid C-glycosides, is flavone glycoside, sterols, sterol glycosides, alkaloids, peptide alkaloids, amino acids, and sugars. Essential oils extracted from its flowers and whole plants contain monoterpene hydrocarbons, oxygenated monoterpenes, sesquiterpene hydrocarbons, and oxygenated sesquiterpenes. This comprehensive review encompasses the structure, botanical compounds composition, ethnobotanical uses, and pharmacological activities reported for Sphaeranthus indicus. It underscores the vast medicinal potential of this plant and highlights its importance in traditional and modern medicinal practices.