Flattening Filter Free Photon Research Articles

RTOG 0915-compliant patient specific QA for lung stereotactic body radiotherapy using the new PTW 1600SRS detector array

PurposeAn area of focus in radiotherapy is the treatment of oligometastatic lung cancer using highly conformal techniques such as SBRT, performed using VMAT that involves flattening filter free (FFF) beams. This study proposes a new calibration procedure for PTW Octavius 1600SRS detector array and was designed to also evaluate clinical and dosimetric aspects of a patient-specific quality assurance (PSQA) for lung SBRT patients. MethodsThe cohort consists of 20 patients, treated for lung metastases using SBRT with 50 Gy dose in 5 fractions (10 Gy/fr). The proposed calibration method uses only one calibration factor determined at maximum dose rate of 6MV FFF photon beam. The dosimetric accuracy of achieving a high dose gradient was analyzed using the RTOG 0915 protocol and was confirmed by PSQA procedures using the PTW Octavius 1600SRS detector. ResultsConformity index, gradient index, maximum dose at 2 cm and V20 parameters were evaluated with clinical favorable results, with only two plans with lesions situated in the inferior lobe exceeding the deviation allowed for the gradient index. Gamma passing rates using the new calibration method were 98.93% and 99.38% for different gamma criteria of 2 mm/2% and 1 mm/3%, respectively. ConclusionsThe proposed method for calibration using one calibration factor at maximum dose rate for the involved photon beam shows clinically acceptable gamma passing rates. Employing the RTOG 0915 protocol for lung SBRT treatment plan evaluation brings important dosimetric information about treatment plan quality and dose gradient fall-off which can be correlated with the results achieved during the pretreatment verification procedures.

Comparison of two different VMAT radiotherapy TPSs for pancreatic cancer using flattening filter free photon beam energy

BackgroundPancreatic cancer is a devastating disease with a poor prognosis, and radiation therapy plays a crucial role in its treatment and management. Conventional radiation therapy (RT) techniques have limitations in delivering adequate doses to the tumor while sparing surrounding normal tissues. However, modern RT techniques such as intensity-modulated radiation therapy (IMRT), volumetric modulated arc therapy (VMAT), and stereotactic body radiation therapy (SBRT) have led to the development of novel approaches that can reduce toxicity. The incorporation of advanced imaging modalities, like four-dimensional computed tomography (4D-CT) and magnetic resonance imaging (MRI), enables enhancement of tumor control and improves conformality and treatment outcomes. Additionally, using flattening filter-free (FFF) beams can further enhance treatment efficiency and efficacy. PurposeThis study aims to compare two different VMAT techniques using two different treatment planning systems (TPSs), Monaco and Eclipse, in the treatment of pancreatic cancer II stage infiltrating duct carcinoma patients using an FFF photon beam. Materials and methods20 pancreatic cancer II stage infiltrating duct carcinoma patients were retrospectively analyzed, and each patient's plans were designed using the two TPSs. The dose distribution of the target using 6 MV FFF for TrueBeam-Varian and organs at risk (OARs) were compared. The monitor unit (MU), treatment time, conformity (CI), and homogeneity (HI) indices were also evaluated. ResultsFor pancreatic cancer patients, the mean dose of the planning target volume (PTV) in the Monaco plan was lower than the Eclipse plan. The plan evaluation parameters in Monaco and Eclipse were similar without significant differences (p-value = 0.152). The Monaco plan was better than the Eclipse plan regarding mean dose and V15Gy of the kidneys; the spinal cord was lowest in the Monaco plan, and the maximum dose and V45Gy of the spinal cord were 592.1 cGy and 1.37% lower than the Eclipse plan, respectively. ConclusionThe VMAT Monaco plan is a favorable TPS for pancreatic cancer patients, providing improved sparing of critical organs while maintaining adequate target coverage.

A comprehensive Study of the Out of Field Non Target Dose Associated with 6 and 10 MV Flattened and Flattening Filter Free X Ray Beam in a True Beam Linear Accelerator.

To evaluate the out-of-field dose associated with flattened (FF) and flattening filter-free (FFF) 6 and 10 MV X-ray beams in a TrueBeam linear accelerator (Linac). Measurements were taken in a slab phantom using the metal oxide semiconductor field effect transistor (MOSFET) detector at varying depths (dmax, 5 cm, and 10 cm) for clinically relevant field sizes and up to 30 cm from the field edges for 6 and 10 MV FF and FFF beams in TrueBeam Linac. Dose calculation accuracy of the analytic anisotropic algorithm (AAA) and Acuros algorithm was investigated in the out-of-field region. Similarly, the out-of-field dose associated with volumetric modulated arc therapy (VMAT) head-and-neck plan delivered to a body phantom was evaluated. The out-of-field dose for both FF and FFF photon beams (6 and 10 MV) decreased with increasing distance from the field boundary and size. Furthermore, regardless of FF in the field, higher-energy photon beams were associated with lower out-of-field dose. Both algorithms underestimated the dose in the out-of-field region, with AAA failing to calculate the out-of-field dose at 15 cm from the field edge and Acuros failing to calculate out-of-field radiation at 20 cm. At 5 cm from the field edge, an average of 50% underestimation was observed, and at 10 cm, an average of 60% underestimation was observed for both FF and FFF (6 and 10 MV) beams. The VMAT head-and-neck plan performed with the FFF beam resulted in a lower out-of-field dose than the FF beam for a comparable dose distribution. Compared with flattened beams, the FFF modes on TrueBeam Linac exhibited a clinically relevant reduction in the out-of-field dose. Further dosimetric studies are warranted to determine the significant benefit of FFF beams across different cancer sites.

Radiobiological analysis of VMAT treatment plan with flattened and flattening filter free photon beam: an EUD and TCP based comparative study.

This study aimed to evaluate the dosimetric and radiobiological differences between 6MV flattened filter (FF) and flattening filter free (FFF) using volumetric modulated arc (VMAT) technique for head and neck (H&N) cancer patients. Fifteen patients with H&N carcinoma were selected and treated with VMAT with FF (VMATFF) treatment plan. Retrospectively, additional VMAT treatment plans were developed using FFF beams (VMATFFF). Radiobiological parameters, such as equivalent uniform dose (EUD), tumor cure probability (TCP), and normal tissue complication probability (NTCP), were calculated using Niemierko's model for both VMATFF and VMATFFF. Correlation between dosimetric and radiobiological data were analyzed and compared. The conformity index (CI) was 0.975 ± 0.014 (VMATFF) and 0.964 ± 0. 019 (VMATFFF) with p ≥ 0.05. Statistically, there was an insignificant difference in the planning target volume (PTV) results for TCP (%) values, with values of 81.20 ± 0.88% (VMATFF) and 81.01 ± 0.92 (%) (VMATFF). Similarly, there was an insignificant difference in the EUD (Gy) values, which were 71.53 ± 0.33 Gy (VMATFF) and 71.46 ± 0.34 Gy (VMATFFF). The NTCP values for the spinal cord, left parotid, and right parotid were 6.54 × 10-07%, 8.04%, and 7.69%, respectively, in the case of VMATFF. For VMATFFF, the corresponding NTCP values for the spinal cord, parotids left, and parotid right were 3.09 × 10-07%, 6.57%, and 6.73%, respectively. The EUD and Mean Dose to PTV were strongly correlated for VMATFFF. An increased mean dose to the PTV and greater TCP were reported for the VMATFF, which can enhance the delivery of the therapeutic dose to the target.

Simulation-guided development of an optical calorimeter for high dose rate dosimetry.

Optical Calorimetry (OC) is based on interferometry and provides a direct measurement of spatially resolved absorbed dose to water by measuring refractive index changes induced by radiation. The purpose of this work was to optimize and characterize in software an OC system tailored for ultra-high dose rate applications and to build and test a prototype in a clinical environment.A radiation dosimeter using the principles of OC was designed in optical modelling software. Traditional image quality instruments, fencepost and contrast phantoms, were utilized both in software and experimentally in a lab environment to investigate noise reduction techniques and to test the spatial and dose resolution of the system. Absolute dose uncertainty was assessed by measurements in a clinical 6 MV Flattening Filter Free (FFF) photon beam with dose rates in the range 0.2-6Gy/s achieved via changing the distance from the source.Design improvements included: equalizing the pathlengths of the interferometer, isolating the system from external vibrations and controlling the system's internal temperature as well as application of mathematical noise reduction techniques. Simulations showed that these improvements should increase the spatial resolution from 22 to 35 lp/mm and achieve a minimum detectable dose of 0.2Gy, which was confirmed experimentally. In the FFF beam, the absolute dose uncertainty was dose rate dependent and decreased from 2.5 ± 0.8 to 2.5 ± 0.2Gy for dose rates of 0.2 and 6Gy/s, respectively.A radiation dosimeter utilizing the principles of OC was developed and constructed. Optical modelling software and image quality phantoms allowed for iterative testing and refinement. The refined OC system proved capable of measuring absorbed dose to water in a linac generated photon beam. Reduced uncertainty at higher dose rates indicates the potential for OC as a dosimetry system for high dose rate techniques such as microbeam and ultra-high dose-rate radiotherapy.

Adapting a practical EPR dosimetry protocol to measure output factors in small fields with alanine.

Modern radiotherapy techniques often deliver small radiation fields. In this work, a practical Electron Paramagnetic Resonance (EPR) dosimetry protocol is adapted and applied to measure output factors (OF) in small fields of a 6 MV radiotherapy system. Correction factors and uncertainties are presented and OFs are compared to the values obtained by following TRS-483 using an ionization chamber (IC). Irradiations were performed at 10cm depth inside a water phantom positioned at 90cm source to surface distance with a 6 MV flattening filter free photon beam of a Halcyon radiotherapy system. OFs for different nominal field sizes (1×1, 2×2, 3×3, 4×4, normalized to 10×10 cm2 ) were determined with a PinPoint 3D (PTW 31022) IC following TRS-483 as well as with alanine pellets with a diameter of 4mm and a height of 2.4mm. EPR readout was performed with a benchtop X-band spectrometer. Correction factors due to volume averaging and due to positional uncertainties were derived from 2D film measurements. OFs obtained from both dosimeter types agreed within 0.7% after applying corrections for the volume averaging effect. For the used alanine pellets, volume averaging correction factors of 1.030(2) for the 1×1 cm2 field and <1.002 for the larger field sizes were determined. The correction factor for positional uncertainties of 1mm was in the order of 1.018 for the 1×1 cm2 field. Combined relative standard uncertainties uc for the OFs resulting from alanine measurements were estimated to be below 1.5% for all field sizes. For IC measurements, uc was estimated to be below 1.0%. A practical EPR dosimetry protocol is adaptable for precisely measuring OFs in small fields down to 1×1cm2 . It is recommended to consider the effect of positional uncertainties for field sizes <2×2cm2 .

Dosimetric and Radiobiological Impact of Flattening Filter‐Free Beam and Dose Calculation Algorithm Using RapidArc Plans for Cervical Cancer Treatment

AbstractPurposeThe aim of this study is to quantify the potential benefits of a flattening filter‐free (FFF) beam and implement a dose‐computation algorithm for cervical radiotherapy through dosimetric and radiobiological analyses using RapidArc.MethodsThirty‐three patients were enrolled, and four RapidArc plans were created for each patient using a dual‐arc flattening filter and 6‐MV FFF photon beams for the two calculation algorithms. Homogeneity index (HI), conformity index (CI), target coverage, monitor units (MUs), and organ‐at‐risk (OAR) dosimetric characteristics were compared between the plans. Radiobiological characteristics and normal tissue complication probability (NTCP) scores were computed for the OAR using different biological models.ResultsNo significant differences were observed in the Dmax, D98%, and CI in the planning target volume (PTV). Both computations estimated a significant difference in V95%, D2%, and HI for the PTV. Furthermore, the FFF beam showed a significant increase in the MUs and a significant reduction in V30% for the femoral heads. The NTCP score showed a significant increase in the late effects on the bladder, rectum, and bowel with FFF beams.ConclusionThe current study recommends FFF beams for better conformity, comparable dose coverage for the target, and OAR sparing invariable to the dose computation algorithm. The difference in the NTCP score for OAR was minimal with the FFF beam.

Assessment of Treatment Plan Quality between Flattening Filter and Flattening Filter Free Photon Beam for Carcinoma of the Esophagus with IMRT Technique.

As compared to the flattened photon beam, removing the flattening filter (FF) from the head of a gantry decreases the average energy of the photon beam and increases the dose rate, leading to an impact on the quality of treatment plans. This study aimed to compare the quality of intensity-modulated radiation therapy (IMRT) treatment plans for esophageal cancer with and without a flattened filter photon beam. In this analytical study, 12 patients, who had already been treated with a 6X FF photon beam, were treated based on new IMRT methods using a 6X the flattening filter-free (FFF) photon beam. Both 6X FF IMRT and 6X FFF IMRT plans used identical beam parameters and planning objectives. All plans were evaluated with planning indices and doses for organs at risk (OARs). Insignificant dose variation was for HI, CI, D98%, and V95% between FF and FFF photon beam IMRT plans. FF-based IMRT plan delivered a 15.51 % and 11.27% higher mean dose to both lungs and heart than the FFF plan, respectively. The integral dose (ID) for the heart and lungs was 11.21% and 15.51%, respectively, less in the IMRT plan with an FFF photon beam. In contrast to the FF photon beam, a filtered photon beam-oriented IMRT plan provides significant OAR sparing without losing the quality of the treatment plan. High monitor units (MUs), low ID, and Beam on Time (BOT) are major highlights of the IMRT plan with FFF beam.

Evaluation of a High-Resolution Large-Area Two-Dimensional Detector Array for Pre-Treatment Verification of Multiple-Target SRS Plans Using a Single Isocenter

<h3>Purpose/Objective(s)</h3> Pre-treatment verification of multiple-target SRS plans using a single isocenter is challenging because of small target sizes and multiple off-isocenter targets. Targets located further away from the isocenter are more sensitive to rotational setup variations, increasing the risk of geometrical miss. It demands high-resolution detector for small target sizes and large detector area for measuring multiple targets at once. The purpose of this study is to evaluate a high-resolution large-area two-dimensional (2D) detector array for pre-treatment verification of multiple-target SRS plans using a single isocenter. <h3>Materials/Methods</h3> A 2D detector array was evaluated for this purpose. It is based on a silicon complementary metal-oxide-semiconductor platform, which enables a compact design, fast read-out, and high pixel density with each pixel comprising a radiation-sensitive photodiode, a capacitor and three transistors. Its spatial resolution is 0.4 mm, with 105,000 pixels across a large active area of 120 × 140 mm². Ten multiple-target SRS plans were selected such that each plan has at least 2 targets appear on a longitudinal plane cross the isocenter. All plans were created in a treatment planning system using 6 MV flattening filter free photon beam. The typical plan consisted of one or two coplanar arcs, and two to three non-coplanar arcs. All plans were delivered in patient geometry with the detector center aligned to the plan isocenter. The detector plane was rotated to the corresponding desired longitudinal plane to measure the composite dose in a single measurement. The smallest target measured was 0.12 cc. The largest center-to-center target separation measured was 12 cm. Six of the plans in which the target separations were relatively short were able to be cross verified with a patient-specific quality assurance (PSQA) tool, whose detector area is of 77 × 77 mm². The measured 2D dose distributions in true composite were compared with the calculated dose distributions. Gamma index analysis was performed using 3%/1 mm criteria with a 10% dose threshold. <h3>Results</h3> With the 2D detector array, the gamma passing rates are all greater than 95% except one, which is 93%. The average gamma-passing rate is 97.7%. For the 6 plans cross verified, the average gamma-passing rates are 98.2% and 96.1% with the 2D detector array and PSQA tool, respectively. <h3>Conclusion</h3> The 2D detector array was demonstrated to be suitable and offers an efficient way for pre-treatment verification of multiple-target SRS plans using a single isocenter. The advantages of this 2D array include: 1) High-resolution of 0.4 mm avoids dose interpolations for plans calculated with 0.5 -1.0 mm dose grid and potentially avoids "false positive" results due to more measured points; 2) Large active area of 120 × 140 mm² allows simultaneous verification of multiple targets in true composite in patient geometry.

Dosimetric Impact on the Flattening Filter and Addition of Gold Nanoparticles in Radiotherapy: A Monte Carlo Study on Depth Dose Using the 6 and 10 MV FFF Photon Beams.

Purpose: This phantom study investigated through Monte Carlo simulation how the dose enhancement varied with depth, when gold nanoparticles (NPs) were added using the flattening filter-free (FFF) photon beams in gold NP-enhanced radiotherapy. Method: A phantom with materials varying from pure water to a mixture of water and gold NPs at different concentrations (3–40 mg/mL) were irradiated by the 6 and 10 MV flattening filter (FF) and FFF photon beams. Monte Carlo simulations were carried out to determine the depth doses along the central beam axis of the phantom up to a depth of 40 cm. The dose enhancement ratio (DER) and FFF enhancement ratio (FFFER) were calculated based on the Monte Carlo results. Results: The DER values were found decreased with an increase of depth and increase of NP concentration in the phantom. For the maximum NP concentration of 40 mg/mL, the DER values decreased 6.9, 12, 4.6 and 7.2% at a phantom depth from 2 to 40 cm, using the 6 MV FF, 6 MV FFF, 10 MV FF and 10 MV FFF photon beams, respectively. The maximum DER values for the 6 MV beams were 1.08 (FF) and 1.14 (FFF), while those for the 10 MV beams were 1.04 (FF) and 1.07 (FFF). When the FF was removed from the linear accelerator head, the FFFER showed a more significant increase of dose enhancement for the 6 MV beams (1.057) than the 10 MV (1.031). Conclusion: From the DER and FFFER values based on the Monte Carlo results, it is concluded that the dose enhancement with depth was dependent on the NP and beam variables, namely, NP concentration, presence of FF in the beam and beam energy. Dose enhancement was more significant when using the lower photon beam energy (i.e., 6 MV), FFF photon beam and higher NP concentration in the study.

A Comprehensive Evaluation of Single Isocenter Multiple Target SRS Plans and the Analytical Relationship between Plan Quality Indices with the Number and Volume of Targets.

To study the relationship of plan quality indices with the number and volume of target for 5 to 10 brain metastases treated with LINAC-based Single Isocenter Multiple Target (SIMT) Stereotactic radiosurgery (SRS) planning and to determine the maximum volume of spherical targets treated without exceeding the normal tissue tolerances. Spherical targets of 5 to 10 numbers per plan, with individual target volumes ranging from 0.025 cc to 11.5 cc, were simulated with randomly drawn planning target volumes (PTVs) within the brain. SIMT SRS plans were generated for the 21 Gy prescription dose with a 6 MV Flattening Filter Free photon beam. Target coverage, organ at risk sparing, plan quality indices, R50%, and gradient measure were studied. Mean brain dose, V12 for Brain minus PTV (BmP), V10, V12, V15, V18, V20, and V24 for brain volume were evaluated. Equations relating the gradient index, mean brain dose, and V12 (BmP) to the given number and volume of the targets were constructed. PTV coverage D98 was 98.77 ± 1.37 %. The mean CIRTOG, QRTOG, HIRTOG, CIP, GI, and R50% of the individual targets were 1.02 ± 0.08, 0.94 ± 0.02, 1.49 ± 0.11, 0.91 ± 0.06, 4.74 ± 2.3, and 4.95 ± 2.67, respectively. The gradient measure achieved was in the range of 0.49 to 1.35 cm. The mean brain dose was in the range of 1.62 to 6.69 Gy. The mean V12 (BmP) per target obtained was 3.85 ± 2.83 cc. Equations relating the number and volume of targets to the gradient measure, mean brain dose, V12 (BmP), and V10-24 can serve as a baseline for multiple brain metastases SIMT planning. The target volume for 5, 6, 7, 8, 9, and 10 targets that can be treated without exceeding V12 (BmP) is 6, 5, 4.7, 4, 3.7, and 3.4 cc, respectively, for the 21 Gy prescription dose.

Dose Estimation Using Optically Stimulated Luminescence Dosimeter and EBT3 Films for Various Treatment Techniques in Alderson Rando Phantom and Estimation of Secondary Cancer Incidence for Carcinoma of Left Breast.

The aim of this study was to measure the dose to planning target and organ at risk (OAR) using Alderson Rando phantom for various treatment techniques in left breast radiotherapy and to estimate the secondary cancer incidence. Eleven different combinations of plans containing four techniques (three dimensional conformal radiotherapy, intensity-modulated radiation therapy [IMRT], volumetric modulated arc therapy [VMAT], and combination of 3DCRT and VMAT plans (HYBRID)) were created with 6 MV FF and 6 MV FFF (flattening filter and flattening filter-free) photon energies in phantom. Planned target volume and OAR doses in 23 different locations were measured using optically stimulated luminescence dosimeter (OSLD) and EBT3 films. Assuming the age of exposure as 30 years, lifetime attributable risk (LAR) was estimated based on excess absolute risk (EAR) models outlined in the Biological Effects of Ionizing Radiation VII report. Film showed maximum deviations of 6.15% with IMRT_C_FF plan when compared with treatment planning system (TPS). The maximum percentage difference of 1.7% was found with OSLD measurement when compared with TPS for VMAT_T_FFF plan. EAR estimation was done for all the OARs including target. The LARs for left lung, right lung, and right breast were evaluated. The maximum LAR values of 2.92 ± 0.14 were found for left lung with VMAT_C_FFF plans. This study shows that both OSLD and EBT3 films are suitable for dose measurements using Rando phantom. OSLD shows superior results when compared with films, especially with relatively larger distances. Maximum LAR values were found with VMAT_C_FFF plans. Considering the secondary cancer risk associated with the patients treated in the younger age group, it is suggested that in vivo dose estimation should be a part of treatment quality audit whenever possible.

Impact of Dosimetric Parameters on Interplay Effects in 6 MV Flattening Filter-Free Photon Beams to Treat Lung Cancer.

Context:Interplay effects have become the significant problem in lung cancer radiotherapy. Since these effects yield dose variation within the target and surrounding tissues.Aim:The aim of this study is to investigate the effect of the dosimetric parameters of interplay effects in 6 MV flattening filter-free (FFF) photon beams for lung cancer.Settings and Design:This study performed planning, measurement, and data analysis sections for examining different breathing amplitudes and phases, doses, dose rates, field sizes, and fractionations.Subjects and Methods:Standard and clinical plans were created on the eclipse treatment planning system. The static and dynamic measurements were performed using a robotic platform and two-dimensional (2D) diode array. The gamma passing rates were defined as the percent of dose variation caused by the interplay effects.Statistical Analysis Used:Unpaired t-test.Results:The outcomes showed three trends between gamma passing rates (γ) and dosimetric parameters. First, a decreasing trend was breathing amplitudes. The lowest γ of maximum amplitudes (2 cm) in both one dimensional and 2D were <25%. Second, an increasing trend was field sizes. The lowest γ of minimum field size (4 cm × 4 cm2) was <55%. Third, constant outcomes were breathing phases, doses, dose rates, and a number of fractions. The γ values of these factors were 53.1%, 55.1%, 34.7%, and 36.7%, respectively.Conclusions:Lung tumor motion-induced interplay effects in 6 MV FFF photon beams are more pronounced for higher breathing amplitudes and smaller field sizes.

Dosimetric evaluation of different planning techniques based on flattening filter-free beams for central and peripheral lung stereotactic body radiotherapy

This study aimed to dosimetrically compare and evaluate the flattening filter-free (FFF) photon beam-based three-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT) for lung stereotactic body radiotherapy (SBRT). RANDO phantom computed tomography (CT) images were used for treatment planning. Gross tumor volumes (GTVs) were delineated in the central and peripheral lung locations. Planning target volumes (PTVs) was determined by adding a 5 mm margin to the GTV. 3DCRT, IMRT, and VMAT plans were generated using a 6-MV FFF photon beam. Dose calculations for all plans were performed using the anisotropic analytical algorithm (AAA) and Acuros XB algorithms. The accuracy of the algorithms was validated using the dose measured in a CIRS thorax phantom. The conformity index (CI), high dose volume (HDV), low dose location (D2cm), and homogeneity index (HI) improved with FFF-VMAT compared to FFF-IMRT and FFF-3DCRT, while low dose volume (R50%) and gradient index (GI) showed improvement with FFF-3DCRT. Compared with FFF-3DCRT, a drastic decrease in the mean treatment time (TT) value was observed with FFF-VMAT for different lung sites between 57.09% and 60.39%, while with FFF-IMRT it increased between 10.78% and 17.49%. The dose calculation with Acuros XB was found to be superior to that of AAA. Based on the comparison of dosimetric indices in this study, FFF-VMAT provides a superior treatment plan to FFF-IMRT and FFF-3DCRT in the treatment of peripheral and central lung PTVs. This study suggests that Acuros XB is a more accurate algorithm than AAA in the lung region.

PO-1582 Spencer-Attix stopping power ratios for flattening filter and flattening filter free photon beams

PO-1582 Spencer-Attix stopping power ratios for flattening filter and flattening filter free photon beams

Verification of Surface Dose for Flattening Filter and Flattening Filter Free Beams in Beam-Matched Medical Linear Accelerators.

Background:The purpose of this study was to evaluate the surface dose (SD) of 6 and 10 MV flattening filter beam (FF) and flattening filter free (FFF) beam for different square field sizes in three Beam-matched medical linear accelerators using a parallel-plate ionization chamber. Materials and Methods:The experiment was carried out in a phantom composed of 40×40 cm2 solid Water slabs of varying thickness. Further sheets of solid water phantom were added to take readings in the build-up region for both SSD and SAD technique. Surface doses are measured with a PPC-05 chamber and DOSE 1 electrometer, at measurement depth of 1 mm interval and all results are plotted relative to the dose measured at Dmax for various field sizes. Surface dose readings are therefore reported as relative surface dose. Results:Surface dose increased linearly with field size for both FF and FFF photon beams in all three beam-matched linear accelerators in both SSD and SAD setup. The surface dose of FFF was higher than FF beams in all field sizes. For the given energy the surface dose difference (relative to 10x10 cm2 field size of 6FF) between FF and FFF beam was larger for large field size. For 6FF and 6FFF beam the surface dose difference for 5x5 cm2 is -5.27%, and for 30x30 cm2 it is 12.91%. The measured surface dose differences between linear accelerators are not statically significant (P>0.989). Similarly, the surface dose difference between SSD and SAD setup was also analysed and had no statistical significance (P>0.849). Conclusion:Study showed that the surface dose difference between beam-matched linear accelerators are insignificant. The surface dose difference between SSD and SAD setup were also found negligible. Most importantly, changing patients between beam-matched linear accelerators will not have any significant changes in surface dose in clinical setup.

Comparison of 2 dynamic conformal arc plans based on high-dose rate flattening filter free beams for peripheral lung cancer.

To compare 2 dynamic conformal arc plans based on the high dose rate flattening filter free (FFF) beams, and to evaluate the dosimetric differences. A total of 20 patients with early peripheral non-small cell lung cancer were selected, and 2 dynamic conformal arc plans were designed in the Eclipse 10.0 treatment planning system (TPS). One of them was based on tumor-center (T-DCA), and the other was based on iso-center (Iso-DCA). Both plans were created by using the Truebeam linear accelerator, based on 6 MV FFF photons with a dose rate at 1 400 monitor unit (MU)/min. All patients received the prescribed dose of 4 800 cGy in 4 fractions (1 200 cGy/fraction). Target coverage and organ at risk limits were planned and designed according to the Radiation Therapy Oncology Group (RTOG) Criteria, and were compared between the T-DCA and the Iso-DCA plans. There was no significant difference in the target coverage between the T-DCA and Iso-DCA plans (P>0.05). Conformal index and homogeneity index had no significant differences (both P>0.05), but the percentage of the maximum dose in any direction 2 cm away from the planned target area (D2 cm) and the ratio of the volume wrapped by the isodose line of 50% prescription dose to the volume of the planned target area (R50%) showed significant differences (both P<0.05). The MU of the Iso-DCA plan was increased by 21% compared with that of the T-DCA plan. Except the maximum dose of spinal cord and esophagus, there was no significant difference in the other dosimetric parameters of the organs at risk between the T-DCA and the Iso-DCA plans (all P>0.05). The dose fall-off of Iso-DCA plan is better than T-DCA plan, but the T-DCA plan is consistently superior in sparing dose to spinal cord and esophagus, and the T-DCA plan has fewer MU.

Dosimetry of a 6 MV flattening filter-free small photon beam using various detectors

The present study aimed to dosimetrically evaluate the small-fields of a 6 MV flattening filter-free (FFF) photon beam using different detectors.The 6 MV FFF photon beam was used for measurement of output factor, depth dose, and beam profile of small-fields of sizes 0.6 cm × 0.6 cm to 6.0 cm × 6.0 cm. The five detectors used were SNC125c, PinPoint, EDGE, EBT3, and TLD-100. All measurements were performed as per the International Atomic Energy Agency TRS 483 protocol. Output factors measured using different detectors as direct reading ratios showed significant variation for the smallest fields, whereas after correcting them according to TRS 483, all sets of output factors were nearly compatible with each other when measurement uncertainty was also considered. The beam profile measured using SNC125c showed the largest penumbra for all field sizes, whereas the smallest was recorded with EDGE. Compared with that of EBT3, the surface dose was found to be much higher for all the other detectors. PinPoint, EBT3, TLD-100, and EDGE were found to be the detector of choice for small-field output factor measurements; however, PinPoint needs special attention when used for the smallest field size (0.6 cm × 0.6 cm). EDGE and EBT3 are optimal for measuring beam profiles. EBT3, PinPoint, and EDGE can be selected for depth dose measurements, and EBT3 is suitable for surface dose estimation.

Commissioning Measurements of Flattening Filter and Flattening Filter Free Photon Beams Using a TrueBeam Stx® Linear Accelerator

Introduction: TrueBeam STx® latest generation linear accelerators (linacs) were installed at Sheikh Khalifa International University Hospital Casablanca, Morocco, this study aimed to present and analyse the dosimetric characteristics obtained during the commissioning. Material and Methods: Dosimetric parameters, including percentage depth dose, profiles, output factor, multileaf collimator (MLC) transmission, and dosimetric leaf gaps (DLG) factors were systematically measured for commissioning. Moreover, six photons beams (i.e., X6MV, X6FFFMV, X10MV, X10FFFMV, X15MV, and X18MV) were examined in this study, and a comparison was made between flattening filter (FF) and flattening filter free (FFF) beams. Results: According to the results, the FF and FFF beams symmetry and flatness were in the tolerance intervals. The unflattness values were estimated at 1.1% and 1.2% for X6FFFMV and X10FFFMV, respectively. Furthermore, tissue phantom ratio(20/10)(TPR) values of the FF beams were X6MV, 0.664; X10MV, 0.738; X15MV, 0.761; and X18MV, 0.778, and the TPR (20/10) values of the FFF beams included 0.632 and 0.703 for 6FFFMV and 10FFFMV, respectively. The results also revealed that the output factor values increased with field size, the surface dose decreased with increasing energy, and the FFF obtained lower mean energy. The MLC transmissions factors were 0.0121, 0.0103, 0.0136, 0.0122, 0.0133, and 0.0121 for X6, X6FFF, X10, X10FFF, X15, and X18, respectively; additionally, the DLG factors were obtained at 0.32, 0.26, 0.41, 0.37, 0.42, and 0.38 mm for X6, X6FFF, X10, X10FFF, X15, and X18, respectively. Conclusion: Photon beams reference dosimetric characteristics were successfully matched with the international recommendations and vendor technical specifications.

An electronic portal image device (EPID)-based multiplatform rapid daily LINAC QA tool.

PurposeTo develop an efficient and economic daily quality research tool (DQRT) for daily check of multiplatform linear accelerators (LINACs) with flattening filter (FF) and flattening filter‐free (FFF) photon beams by using an Electronic Portal Image Device (EPID).Materials and MethodsAfter EPID calibration, the monitored parameters were analyzed from a 10 cm × 10 cm open and 60° wedge portal images measured by the EPID with 100 MU exposure. Next, the repeatability of the EPID position accuracy, long‐term stability, and linearity between image gray value and exposure were verified. Output and beam quality stability of the 6‐MV FF and FFF beams measured by DQRT with the introduced setup errors of EPID were also surveyed. Besides, some test results obtained by DQRT were compared with those measured by FC65‐G and Matrixx. At last, the tool was evaluated on three LINACs (Synergy, VersaHD, TrueBeam) for 2 months with two popular commercial QA tools as references.ResultsThere are no differences between repeatability tests for all monitored parameters. Image grayscale values obtained by EPID and exposure show good linearity. Either 6 MV FF or FFF photon beam shows minimal impact to the results. The differences between FC65‐G, Matrixx and DQRT results are negligible. Monitor results of the two commercial tools are consistent with the DQRT results collected during the 2‐month period.ConclusionWith a shorter time and procedure, the DQRT is useful to daily QA works of LINACs, producing a QA result quality similarly to or more better than the traditional tools and giving richer contents to the QA results. For hospitals with limited QA time window available or lack of funding to purchase commercial QA tools, the proposed DQRT can provide an alternative and economic approach to accomplish the task of daily QA for LINACs.