This paper presents an experimental investigation on the performance of cold-formed stainless steel built-up closed section stub columns. The built-up sections were composed by assembling two channel components at the flanges, which were brake-pressed from high-strength austenitic and duplex stainless steel thin sheets. Three types of built-up sectional profiles were formed by connecting two unstiffened channels (i.e., unlipped channels), two edge-stiffened channels (i.e., lipped channels) as well as one unstiffened channel and one edge-stiffened channel, respectively, using self-plugging rivets. Four sectional series were devised to cover nominal overall web height-to-plate thickness ratio values of 50, 60, 67 and 80. In order to obtain the actual material properties considering the cold-work effect, tensile coupon tests were carried out on both flat and corner longitudinal coupon specimens. In addition, a total of 29 fixed-ended stub columns including 19 specimens without holes and 10 specimens with circular web holes were tested under axial compression. The experimental results involving failure modes, ultimate capacities and responses of load versus axial shortening were obtained and fully documented. The effects of sectional profile types, overall web height-to-plate thickness ratio and hole diameter-to-overall web height ratio on the performance of cold-formed stainless steel built-up closed section stub columns were examined. Moreover, the appropriateness of design rules as prescribed in the recently updated American Specification ASCE/SEI 8–22 was evaluated. It was revealed that the codified design provisions generally provided unconservative strength predictions for the high-strength austenitic and duplex stainless steel built-up closed section stub columns both without and with circular web holes. Reliability analyses were performed in this study, and the compressive strength predictions of the built-up closed sections according to the existing design rules were found to be unreliable for the high-strength austenitic stainless steel stub columns without holes as well as the duplex stainless steel stub columns without and with circular web holes.