Markov Chain Monte Carlo (MCMC) algorithms are commonly used to sample from graph ensembles. Two graphs are neighbors in the state space if one can be obtained from the other with only a few modifications, e.g., edge rewirings. For many common ensembles, e.g., those preserving the degree sequences of bipartite graphs, rewiring operations involving two edges are sufficient to create a fully connected state space, and they can be performed efficiently. We show that, for ensembles of bipartite graphs with fixed degree sequences and number of butterflies (k_{2,2} bicliques), there is no universal constant c such that a rewiring of at most c edges at every step is sufficient for any such ensemble to be fully connected. Our proof relies on an explicit construction of a family of pairs of graphs with the same degree sequences and number of butterflies, with each pair indexed by a natural c, and such that any sequence of rewiring operations transforming one graph into the other must include at least one rewiring operation involving at least c edges. Whether rewiring this many edges is sufficient to guarantee the full connectivity of the state space of any such ensemble remains an open question. Our result implies the impossibility of developing efficient, graph-agnostic, MCMC algorithms for these ensembles, as the necessity to rewire an impractically large number of edges may hinder taking a step on the state space.