The beneficial effects of cardiorespiratory fitness (CRF) on mortality are well known. However, the relation of musculoskeletal fitness (MSF), specifically muscular strength and endurance, to mortality risk has not been as thoroughly examined. PURPOSE To determine if a relation exists between MSF and mortality after controlling for age, sex, BMI, health status, current smoking status, cholesterol, SBP, and treadmill measured CRF. METHODS Individuals in the Aerobics Center Longitudinal Study who completed at least one medical examination and a MSF assessment at the Cooper Clinic in Dallas, TX between 1981 and 1989 were potential subjects. 7605 men and 1500 women, 20–82 years of age, with a total follow-up of 106,046 person-years met these criteria. The MSF assessment included a 1-minute sit-up test, a 1-repetition maximal leg press and a 1-repetition maximal bench press. All-cause mortality rates were calculated for low, moderate, and high MSF strata. Mortality surveillance through 1996 primarily using the National Death Index confirmed 194 deaths in this study group (2.1%). RESULTS The age- and sex-adjusted mortality rate of the lowest MSF category was almost twice that of those in the moderate MSF category (23.9 vs. 13.5 per 10,000 person-years, respectively). Individuals in the highest MSF category had a mortality rate of 15.4 per 10,000 person-years. The moderate and high MSF groups had relative risks of 0.64 (95%CI 0.44–0.93) and 0.80 (95%CI 0.49–1.31), respectively after adjustment for age, sex, BMI, health status, current smoking status, cholesterol, SBP, and CRF when compared with the low MSF group. CONCLUSION Mortality rates across low, moderate, and high musculoskeletal fitness categories suggest a threshold effect between low musculoskeletal fitness and moderate/high musculoskeletal fitness and all-cause mortality in the presence of other health factors. Supported in part by NIH grant AG06945
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