PurposeCan regional economic complexity improve the employment effect, and is the employment structure also affected by heterogeneity? In order to solve these doubts, this paper plans to carry out systematic theoretical analysis and quantitative tests on these problems.Design/methodology/approachBased on the macroeconomic data of 129 countries from 1995 to 2022, this paper empirically studies the impact of economic complexity on the employment effect and its mechanism channel by building relevant models.FindingsThe results show that regional economic complexity can significantly improve the employment effect of society. At the same time, regional economic complexity has an indirect positive role in promoting employment from two aspects: accumulating fiscal surplus and increasing the working-age population. The former can stimulate employment policies by increasing the government’s tax sources, while the latter can increase production specialization and complexity by stimulating demand and increasing employment. In addition, regional economic complexity will lead to job market differentiation, making the boundary between the service sector and the labor market between industry and agriculture and between the informal employment market and the formal employment more obvious, thus triggering the substitution effect of employment.Originality/valueThe possible innovations and marginal contributions of this paper are as follows: First, there are many studies on the influencing factors of employment or unemployment, and this paper provides a new research direction for the literature on the influencing factors of employment effect by using the concept of regional economic complexity for the first time. Second, this paper broadens the research perspective of the employment effect of regional economic complexity, divides the employment substitution effect of various sectors from the perspective of industrial structure and further analyzes the employment promotion effect of regional economic complexity.