63-year-old female with PMH significant for Stage 1a endometrial adenocarcinoma s/p robotic total hysterectomy, had a fall 2 months prior to presentation, with subsequent development of left gluteal and labial numbness. She presented with subacute onset of urinary retention, constipation, weight loss, and radiating left lower extremity pain associated with dysesthesia and impaired gait. Conservative measures were ineffective (combination of NSAIDs, opioids and gabapentin). Typically, the diagnosis of Lumbosacral plexopathy (LSP) requires a thorough clinical evaluation due to a wide differential. However, our patient’s diagnosis was rather brisk due to an aggressive carcinoma causing severe localized pain. In cases of tumor compression, the L4-S1 segment is commonly affected (>50% of cases) followed by L1-L4 segment (31%) and pan-plexopathy (about 10%). At 42-month follow-up, 86% of patients diagnosed with malignancy-induced LS plexopathy had expired. DRG stimulation is approved for CRPS, persistent post-surgical pain syndrome, and peripheral neuropathy for T10-below. To our knowledge, this is the first report of successful application of DRG stimulation trial in the acute malignant pain crisis and palliative care setting.