The work presented here proposes a contribution on the analysis of brake squeal phenomenon using a transient coupled finite element-discrete element method (FEM-DEM) simulation with pad surface topography evolution. To build the coupled FEM-DEM model, a non-overlapping strong coupling is first employed between the FEM and DEM subdomains. Second, a new calibration methodology of the DEM microscopic properties is proposed based on the eigenvalue analysis of the full model. The results of the coupled FEM-DEM model show a good agreement in terms of unstable frequencies and the evolution of the pad contact state history when compared to full FEM models, both for new and worn pad topographies. The evolution of the pad surface topography during the transient analysis results in a complex frequency behaviour, with abrupt shifts of instabilities and new operating deflection shapes, in agreement with reported experimental results. The proposed coupled FEM-DEM model thus seems to be a valuable tool for a better understanding of the squeal triggering due to the evolution of the pad surface topography. This contribution paves the way to advanced numerical analyses of brake squeal phenomenon, which triggering conditions are still under investigation.