The computation of two-loop amplitudes for the production of multiple Higgs and electroweak gauge bosons via gluon fusion with exact dependence on quark masses relies primarily on numerical methods. We propose a framework that enables their numerical evaluation in momentum space. The method is inspired by the factorization of infrared divergences in QCD scattering amplitudes. It extends techniques introduced for electroweak gauge boson production from quark-antiquark annihilation to processes with external gluons. By combining diagrammatic integrands, we make use of local cancellations between diagrams that automatically eliminate most non-factoring infrared singularities. With a limited number of counterterms, we then derive two-loop integrands for which all soft and collinear singularities factorize locally. We hope that the local subtraction techniques presented in this article will play a useful role in extending the local factorization formalism to two-loop amplitudes for arbitrary processes.
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