Final Test Research Articles

A study on digital tooth preparation assessment software in undergraduate pre-clinical skills teaching

IntroductionAims This research aims to evaluate the effectiveness and efficiency of the PrepCheck digital system as an additional feedback tool in enhancing undergraduate dental students’ tooth preparation skills and its potential to enhance students’ learning experience.Material and MethodsA total of 55 BDS3 students attending the “Crowns Course” and divided into three groups participated in the study. One group (n = 24) was randomly selected as the case group and received feedback using the digital tooth preparation analysis system, PrepCheck, alongside standard visual assessment. The other two groups (n = 31) served as controls and only received standard visual feedback. All students’ tooth preparations for the final test were digitally assessed using PrepCheck against a faculty-approved master preparation. The tooth preparation quality was compared between the case and control groups, employing two distinct grading methods. Additionally, a questionnaire was provided to students who used the digital system to gather their feedback.ResultsThe findings revealed a positive trend in performance among the case group when using the PrepCheck system. However, the analysis showed no statistically significant differences between the groups in both the tutor assessment only and tutor assessment in addition to using the PrepCheck report. Despite the absence of statistically significant differences, qualitative feedback from participants indicated a favourable reception of the digital system.ConclusionsWhile the PrepCheck digital system displayed potential in complementing traditional teaching methods and enhancing the learning experience, its integration posed challenges, particularly concerning time constraints. Further research is recommended to investigate further the potential longer-term effects and potential useful applications for integrating digital systems like PrepCheck into dental education.

Development of A Science Module Based on Local Culture of NTT to Enhance Critical Thinking Skills of Prospective Elementary School Teachers

The research aims to develop a Science Module based on Local Culture to enhance the Critical Thinking Skills of prospective Elementary School Teachers. This type of research is development research, using the 4D model (Define, Design, Develop, and Disseminate). The subjects of this study were 30 fifth-semester students of the Elementary School Teacher Education Program, who acted as prospective teachers and used the Local Culture-Based Science Module in their coursework as part of a trial of the module's use. The data collection methods employed were questionnaires to gather information on validation, attractiveness, and practicality, as well as tests to assess effectiveness. The data analysis technique used was descriptive quantitative analysis, where total scores and values were calculated and then averaged to be interpreted according to predetermined criteria. The results obtained from the research process showed that the Local Culture-Based Science Module was valid with a validity score of 3.85, attractive with a score of 82.2, practical with a score of 80, and effective with an average final test score of 83.06. In conclusion, the Local Culture-Based Science Module is valid, attractive, practical, and effective for use as a teaching guide for prospective elementary school teachers

Baseplate version in reverse shoulder arthroplasty: does excessive retroversion or anteversion affect functional activities of daily living?

While bone grafting and augmented components can help restore reverse shoulder arthroplasty (RSA) baseplate version close to neutral, the indication for version correction in RSA is unclear. The purpose of this study was to compare the clinical outcomes of RSA baseplates in high degrees of retroversion and anteversion to components in more neutral version. Patients who underwent RSA with minimum two year follow-up were identified from an institutional registry. An RSA system with a glenosphere that is two-thirds of a sphere was utilized. Post-operative radiographs were used to determine baseplate version, and patients were grouped into four categories: ≥ 10 degrees (moderate to severe anteversion; n = 14), 10 to -10 degrees (neutral; n = 69), -10 to -20 (moderate retroversion; n = 25), and ≤ -20 degrees (severe retroversion; n = 7). The outcomes of interest were ability to perform functions requiring internal rotation, external rotation and cross-body adduction, as well as complications and revisions. There were no differences in final Simple Shoulder Test (SST), final American Shoulder and Elbow Surgeons score (ASES) or change in SST from pre- to post-operative across the four version groups. There was no linear correlation between baseplate version and final SST. There were no statistically significant differences in difficulty performing tasks related to internal rotation, external rotation, and cross-body adduction among the four baseplate version groups; however, patients with moderate to severe anteversion had a greater frequency of difficulty putting on a coat (86%) compared to patients with neutral version (42%), moderate retroversion (45%) and severe retroversion (0%) (p = 0.021). There were no differences in rates of complications and revisions across the four groups. This study did not find evidence that high values of baseplate retroversion or anteversion were associated with inferior patient reported outcomes or functional rotation after reverse total shoulder arthroplasty. Level 3, retrospective comparative study.

Pengaruh Latihan Triangel Terhadap Ketepatan Passing Ekstrakurikuler Futsal SMK Muhammadiyah 2 Kuningan

The Effect of Triangel Training on the Accuracy of Passing in Futsal Players of SMK Muhammadiyah 2 Kuningan, Physical Education and Recreation Study Program (PJKR). This study aims to determine the influence of the triangle training method on the accuracy of passing in futsal players of Smk Muhammadiyah 2 Kuningan. The subject of this study is students who were selected to participate in futsal at SMK Muhammadiyah 2 Kuningan. The population in this study is all futsal players of SMK Muhammadiyah 2 Kuningan. The sampling technique used is total sampling, which amounts to 20 0rang. The research method that the author uses to test the correctness of the hypothesis that has been proposed is the experimental method. The instrument used in this study is the passing accuracy test. The data analysis used is a quantitative descriptive test and a t-test. The results of this study showed that the triangel training method on the accuracy of the pass in extracurricular futsal players of SMK Muhammadiyah 2 Kuningan was 30.45%" at a significance level of 0.000 < 0.05. With the results of the evaluation of normality test data, homogeneity test, hypothesis test and the results of the final test or t were calculated as 6,430 > 2.09. In addition, the success in increasing the influence of triangel exercises is also supported by methods including providing training time and providing motivation.

Preparation and Characterization of Bio-Fibre Based on the Biological Properties of Bougainvillaea, Loofah, and Aloe Vera

This study is based on environmental sustainability and aims to explore the preparation and evaluation of biodegradable bio-fibre materials using discarded bougainvillaea, loofah, and aloe. After sorting and analyzing the existing literature, it is found that research on bougainvillaea, loofah, and aloe primarily focuses on environmental science, horticulture, biology, light industry, and pharmacy, while research on bio-fabric combining bougainvillaea, loofah, and aloe in two or three combinations remains unexamined. This study adopts both observational and experimental methods to identify candidate varieties suitable for natural dyeing by observing the characteristics of bougainvillaea and by preparing and testing bio-fibre materials through experimentation. Notably, the beet pigment found in bougainvillaea serves as a natural dye, the α-cellulose and hemicellulose in loofah sponge provide strong hydrophilicity, and the caffeic acid and rhamnolipids in aloe exhibit antioxidant and antibacterial properties, thereby improving the fabric’s safety. Experimental results and final bio fibre performance tests indicate that fibres made from these three plants have a stable internal structure, abrasion resistance of over 30,000 cycles, colour fastness concentrated at level 4, and a contact angle of less than 90°, thereby showing good stability, abrasion resistance, colour fastness, and hydrophilicity. Consequently, this study finds that bio-fibres prepared from bougainvillaea, loofah, and aloe demonstrate promising performance and are expected to contribute to the development of sustainable fibres in the future.

Cardiorespiratory Responses to Flywheel-Based Inertial Training Squats With Varying Moments of Inertia.

Mitchinson, CJ, Best, S, Caruso, J, and Bollinger, LM. Cardiorespiratory responses to flywheel-based inertial training squats with varying moments of inertia. J Strength Cond Res XX(X): 000-000, 2024-Flywheel-based inertial training (FIT) has gained popularity as a means to enhance muscle hypertrophy. Other applications, such as aerobic exercise training, remain unexplored. The aim of this study was to determine the cardiorespiratory responses to acute FIT with varying moments of inertia (MOIs). Methods: Overall, 20 (10 M, 10 F) healthy, physically active subjects underwent maximal graded exercise testing and completed 3 bouts of FIT exercise (1 familiarization session and 2 identical data collection sessions). Subjects completed quarter squats (60° peak knee flexion) at a pace of 50 squats·minute-1 until volitional fatigue. Flywheel-based inertial training MOI was increased by 0.005 kg·m2 every 3 minutes until a final workload of 0.020 kg·m2. Heart rate and gas exchange data were collected continuously and averaged over the final 60 s of each stage. Data were analyzed by a linear mixed model. Results: During the final testing session, there was a main effect of MOI to increase heart rate (HR), V̇o2, and RER. Men displayed greater oxygen consumption, but asimilar %V̇o2peak compared with women. We noted a significant inertia × sex interaction where RER tended to be lesser in women at higher MOI. In the final stage of exercise (MOI: 0.020 kg·m2), HR and V̇o2 were approximately 75-80 and 55% of peak, respectively, and RER was approximately 0.95-1.00. Conclusions: FIT quarter squats elicit moderate HR and V̇o2 responses, but near-maximal RER suggests a novel metabolic training stimulus. This exercise may supersede thelactate threshold and may not be sustainable for prolonged times. The physiological and performance effects of training in this manner are unclear.

Impact of conjugated material modified intelligent taekwondo equipment on the physical fitness of college students

The cultivation of physical fitness among college students plays an important role in their comprehensive development and healthy growth process. Traditional training methods and equipment lack flexibility, making it difficult to effectively improve the athletic ability and physical fitness of college students. In order to improve the physical health level of college students and improve the quality and level of their sports training, this article conducted in-depth research on intelligent Taekwondo equipment modified with conjugated materials and its impact on the physical fitness of college students. This article first analyzed the requirements for intelligent Taekwondo equipment, and then based on this, graphene was used as the main material to prepare it using electrochemical stripping method, and modified by doping nitrogen atoms. Finally, the modified graphene was used in the design of intelligent Taekwondo equipment. To verify the application effect of modified graphene intelligent Taekwondo equipment, this article conducted testing and analysis on it. The results showed that compared to conventional training methods, students who applied modified graphene intelligent Taekwondo equipment for auxiliary training improved their final test scores in flexibility, endurance, and muscle strength indicators by 0.96 points, 1.02 points, and 0.65 points, respectively. The conclusion indicated that the intelligent Taekwondo equipment modified with graphene conjugated materials had a positive impact on the improvement of physical fitness of college students, which helped to improve their physical health level.

A peer teaching module for medical residents on critical appraisal of medical articles: context and pilot testing

BackgroundThe ability of healthcare providers to access and use published research correctly is crucial for the quality of healthcare services, enabling selection of the most effective treatment modalities, and avoidance of medical errors. Physicians need strong critical appraisal (CA) skills to manage rapidly evolving medical knowledge.MethodsA standard peer-teaching module was prepared for medical residents on CA. The module included topic-specific educational materials, discussion articles, and question sets and was pilot-tested among medical residents, allowing for revisions based on participants’ feedback. Training module was prepared by a senior epidemiologist and a community medicine (public health) resident, based on the context of a similar graduate course; the resident underwent four months of personal training preceding the pilot testing, which was conducted as a 12-week program in September-November 2023, supervised by experts. Online training extended our reach to resident working nationwide. Recruitment was enabled via social media and various medical specialty organizations. Evaluations included initial, session-specific, and final tests for measuring progress in knowledge on CA, based on participants’ self-assessments, and external auditors’ scoring of the process.ResultsA total of 52 residents from 19 universities and nine specialty programs participated in pilot testing. Of these, 48 completed the program through the post-test, with 83% (n = 40) scoring above 65%, received a certificate of achievement. Median scores showed a 32% increase in knowledge, a 75% increase in confidence in CA skills, and a 50% decrease in stress-related to CA practice. Additionally, 82.5% (n = 33) of those who completed the module expressed interest in offering similar training sessions to their local peers.ConclusionThe online peer teaching of the CA module successfully increased participants’ knowledge and self-confidence in critical appraisal.Clinical trial numberNot applicable.

Physical Activity Levels and Women’s Mental Health After COVID-19 Infection

Background: The aim of this research is to investigate the associations between physical activity and mental health parameters (depression, anxiety, and stress) among women who have recovered from COVID-19; Methods: This research involved two measurements: the initial test, conducted 2-to-4 weeks post-COVID infection, and the final test, performed 14-to-16 weeks after the virus’s activity. The sample consisted of women (n = 190) aged 20 to 60 (47.60 ± 11.1, 47.60 ± 11.1, mean ± Std.Dev.) who were infected with COVID-19. To assess the level of physical activity, a longer version of the IPAQ questionnaire was used. Self-assessment of mental health was determined by a longer version of the DASS questionnaire; Results: The t-test analysis revealed significant differences in mental health and physical activity levels between the initial and final measurements. After three months, subjects showed lower mental health scores (indicating improvement) and higher Metabolic Equivalent of Task (MET) values across all physical activity domains, with moderate physical activity showing the greatest increase. The regression analysis showed that at the initial measurement, there was no statistically significant association of physical activity with mental health parameters. Three months after the initial measurement, regression analysis showed that there was a statistically significant association of physical activity with anxiety (F = 3.97; p = 0.000) and depression (F = 3.34; p = 0.001) but not with stress (F = 1.67; p = 0.106); Conclusions: This research revealed that higher levels of physical activity improved mental health in post-COVID-19 women, with varying effects on anxiety and depression depending on the activity domain.

Psychometric Analysis of Validity and Reliability of The Indonesian Version of The Modified Fatigue Impact Scale in Chronic Disease Patients

Fatigue is a lack of physical or mental energy that can be felt by individuals and can disrupt daily activities. Fatigue causes a constant decrease in vitality, a lack of energy, and prevents sleep gaps from being filled, ultimately leading to a decline in productivity and quality of life. The prevalence of fatigue in chronic patients varies, as there is no specific data available. However, the prevalence of fatigue depends on the chronic disease in question, such as chronic kidney disease, diabetes mellitus, and heart disease. To obtain a valid and reliable Indonesian version of the MFIS instrument that can measure fatigue in patients with chronic diseases. The sampling technique used was based on the population, using a non-probability sampling method with purposive sampling. The population in this study consisted of patients with chronic diseases (Diabetes Mellitus, Congestive Heart Failure, Stroke). The population was 244 respondents (4 respondents for language comprehension, 30 respondents for validity and reliability testing, and 210 respondents for the final instrument test). The validity test results, with a sample of (n=210 respondents), showed a loading factor value greater than 0.135, indicating that all MFIS items were valid and highly correlated. The reliability test (n=210 respondents) yielded a Cronbach’s Alpha coefficient of 0.869. This study demonstrates that the Indonesian version of the MFIS instrument is valid and highly correlated. This instrument can be used to identify fatigue in chronic diseases and can serve as a guideline for nurses to implement fatigue interventions, thus helping to reduce and address fatigue issues in patients with chronic diseases.

An experiment on the differentiated teaching of English grammar to students at a technical university through educational interaction with a chatbot based on generative AI

Importance. Traditional methods and approaches in learning English language are substituted by digitalization of the educational process. The research aimed at developing and testing the methodology of teaching a foreign language to students of a technical university through educational interaction with a chatbot with generative AI, the purpose of which is to identify the effectiveness of the use of digital tools in pedagogical practice is determined as relevant and demanded.Research Methods. The research material was theoretical, empirical and analytical methods. First-year students of National Research Nuclear University “MEPhI” participated in the experiment on differentiated teaching of English grammar to students of technical universities by means of educational interaction with an AI chatbot.Result and Discussion. The experiment consisted of three stages: ascertaining, formative and control. At the first stage, an entrance grammar test was conducted to determine the initial level of grammatical skills of students in the control and experimental groups. At the second stage, the experimental group was taught English grammar using the proposed methodology, while the students of the control group were taught in the traditional way. At the last stage, the students of the two groups underwent final grammar testing, which allowed us to compare the results and conduct statistical analysis of the data.Conclusion. The statistical data confirm the validity of the author's methodology for differentiated teaching of English grammar to students of technical university through educational interaction with a chatbot.

Recognition of Maize Tassels Based on Improved YOLOv8 and Unmanned Aerial Vehicles RGB Images

The tasseling stage of maize, as a critical period of maize cultivation, is essential for predicting maize yield and understanding the normal condition of maize growth. However, the branches overlap each other during the growth of maize seedlings and cannot be used as an identifying feature. However, during the tasseling stage, its apical ear blooms and has distinctive features that can be used as an identifying feature. However, the sizes of the maize tassels are small, the background is complex, and the existing network has obvious recognition errors. Therefore, in this paper, unmanned aerial vehicle (UAV) RGB images and an improved YOLOv8 target detection network are used to enhance the recognition accuracy of maize tassels. In the new network, a microscale target detection head is added to increase the ability to perceive small-sized maize tassels; In addition, Spatial Pyramid Pooling—Fast (SPPF) is replaced by the Spatial Pyramid Pooling with Efficient Layer Aggregation Network (SPPELAN) in the backbone network part to connect different levels of detailed features and semantic information. Moreover, a dual-attention module synthesized by GAM-CBAM is added to the neck part to reduce the loss of features of maize tassels, thus improving the network’s detection ability. We also labeled the new maize tassels dataset in VOC format as the training and validation of the network model. In the final model testing results, the new network model’s precision reached 93.6% and recall reached 92.5%, which was an improvement of 2.8–12.6 percentage points and 3.6–15.2 percentage points compared to the mAP50 and F1-score values of other models. From the experimental results, it is shown that the improved YOLOv8 network, with high performance and robustness in small-sized maize tassel recognition, can accurately recognize maize tassels in UAV images, which provides technical support for automated counting, accurate cultivation, and large-scale intelligent cultivation of maize seedlings.

HISTÓRIA DA AVALIAÇÃO DA ALFABETIZAÇÃO NOS GRUPOS ESCOLARES BOM JESUS E CLARIMUNDO CARNEIRO: ENTRE LEGISLAÇÕES E PRÁTICAS

The article aims to analyze the literacy evaluation practices in the first primary grade of the Bom Jesus and Clarimundo Carneiro School Groups, in Uberlândia/MG, in the period from 1955 to 1974. The evaluation of learning in modernity, according to Luckesi (2011), is a recent and distinct practice of the school exam, which historically dates back to the sixteenth and seventeenth centuries. Throughout the text, different concepts of evaluation are discussed, such as the positivist view that focuses on classification, contrasting with the dialectic that values learning as an inclusive process. The article revisits educational legislation in Minas Gerais and Brazil that influenced evaluation practices, starting with Decree-Law No. 8,529/1946, which established guidelines for primary education, and passing through Law 4024/1961, which defined guidelines and bases for education. The study points out that the evaluations were carried out mainly through monthly and final tests, reflecting a traditional approach to teaching. The evaluation practices in the two school groups reveal some similarities and differences. At the Clarimundo Carneiro School Group, the evaluations were made both through tests prepared by the literacy teachers and by external tests from the Department of Education, in addition to a reading exam carried out by the principal. In the Bom Jesus School Group, the principal and vice-principal were responsible for evaluations that included dictations, reading and problem solving, reflecting a collaborative work between the literacy teachers and the school managers.

Interpolated pretesting can boost memory of related and distinct prose materials

The pretesting effect refers to the finding that tests performed before to-be learned material is encountered can enhance later retention of the material, even when no correct answers were provided on the initial pretest. The goal of the present study was to examine whether interspersing pretest questions between the study of multiple segments consisting of prose passages can induce a pretesting effect on a final cumulative recall test on all segments. To this end, participants studied four segments which were either thematically related (Experiment 1) or distinct (Experiment 2) and either received pretest questions about each segment immediately prior to study of the segment (pretest condition) or not (study-only condition). Results of the cumulative final test performed 24 h after study of the segments showed for both experiments that interpolated pretesting enhanced correct recall of the segments. The findings thus suggest that the positive effects of pretesting on memory generalize from the standard single-list design to a multiplelists design when pretests are performed prior to study of each list. Interpolated pretesting thus may play a critical role as a potential learning tool in educational practice.

Using the phenomenology of knowledge-based retrieval failures in younger and older adults to characterize proximity to retrieval success and identify a Zone of Proximal Retrieval

Across the lifespan, accumulated knowledge can become inaccessible, with everyone having experienced retrieval failures. These failures are accompanied by varied mental experiences (phenomenology), but little research has been done to distinctly characterize their full range. The present studies examined the extent to which varying failures, ranging from imminent retrieval like tip-of-the-tongue states to unavailability, are associated with distinct phenomenological experiences. Proposing a Proximity to Retrieval Success framework for retrieval failures, we hypothesize that the probability of retrieval success (accessibility) will vary systematically from high to low, with intermediate probabilities reflecting a Zone of Proximal Retrieval. Older and younger adults answered age-normed, short-answer general knowledge questions and selected one of four phenomenological retrieval failure experiences when unable to answer. In Experiment 1, participants completed a subsequent multiple-choice test, whereas Experiments 2 and 3 involved correct answer feedback before completing a final short-answer test. Consistently, and in line with predictions from the Proximity to Retrieval Success framework, accuracy on the subsequent test systematically increased as a function of the selected phenomenological retrieval failure state’s proximity to the accessibility threshold, with the lowest accuracy for items judged as not known. These findings indicate robust successful metacognition linking phenomenological experiences of retrieval failures with behavioral memory performance. Implications for the practical and theoretical usefulness of this work are discussed. (215 words)

Clinical application of machine-based deep learning in patients with radiologically presumed adult-type diffuse glioma grades 2 or 3

Abstract BACKGROUND Radiologically presumed diffuse lower-grade glioma (dLGG) are typically non or minimal enhancing tumors, with hyperintensity in T2w-images. The aim of this study was to test the clinical usefulness of deep learning (DL) in IDH mutation prediction in patients with radiologically presumed dLGG. METHODS 314 patients were retrospectively recruited from six neurosurgical departments in Sweden, Norway, France, Austria, and the United States. Collected data included patients’ age, sex, tumor molecular characteristics (IDH, and 1p19q), and routine preoperative radiological images. A clinical model was built using multivariable logistic regression with the variables age and tumor location. DL models were built using MRI data only, and four DL architectures used in glioma research. In the final validation test, the clinical model and the best DL model were scored on an external validation cohort with 155 patients from the Erasmus Glioma Dataset. RESULTS The mean age in the recruited and external cohorts was 45.0 (SD 14.3) and 44.3 years (SD 14.6). The cohorts were rather similar, except for sex distribution (53.5% vs 64.5% males, p-value 0.03) and IDH status (30.9% vs 12.9% IDH wild-type, p-value <0.01). Overall, the area under the curve for the prediction of IDH mutations in the external validation cohort was 0.86, 0.82, and 0.87 for the clinical model, the DL model, and the model combining both models’ probabilities. CONCLUSIONS In their current state, when these complex models were applied to our clinical scenario, they did not seem to provide a net gain compared to our baseline clinical model.

Reliable and easy-to-use calculating tool for the Nail Psoriasis Severity Index using deep learning

Since nail psoriasis restricts the patient’s daily activities, therapeutic intervention based on reliable and reproducible evaluation is critical. The Nail Psoriasis Severity Index (NAPSI) is a validated scoring tool, but its usefulness is limited by interobserver variability. This study aimed to develop a reliable and accurate NAPSI scoring tool using deep learning. The tool “NAPSI calculator” includes two parts: nail detection from images and NAPSI scoring. NAPSI was annotated by nine nail experts who are board-certified dermatologists with sufficient experience in a specialized clinic for nail diseases. In the final test set, the “NAPSI calculator” correctly located 137/138 nails and scored NAPSI with higher accuracy than the compared six non-board-certified residents: 83.9% vs 65.7%; P = 0.008 and four board-certified non-nail expert dermatologists: 83.9% vs 73.0%; P = 0.005. The “NAPSI calculator” can be readily used in a clinical situation, contributing to raising the medical practice level for nail psoriasis.

THE EFFECT OF USING YOUTUBE VIDEO ON THE STUDENTS’ ABILITY IN WRITING PROCEDURE TEXT AT THE SEVENTH GRADE OF SMP SWASTA TELADAN PEMATANGSIANTAR

The purpose of this study is to find out the impact of using YouTube videos on the procedural writing skills of seventh grade students at SMP Swasta Teladan Pematangsiantar. This study focuses on the use of YouTube videos as a tool for students' writing on the topic “Making a Drink.” This study uses quantitative research with a quasi-experimental research design from Creswell. The population of this study consisted of seventh grade students of SMP Swasta Teladan Pematangsiantar, a total of 64 students. The sample of this study was divided into two groups, namely the experimental class (VII-A), consisting of 32 students who used YouTube video as a medium, and the control class (VII-B), consisting of 32 students who used only the teacher's explanation. Data were collected using writing tests for the pre-test and the final test. The researcher found that the mean of the pre-test was 52.6 in the experimental group and 56.2 in the control group. The mean of the final test in the experimental group was 75.8 and 72.1 in the control group. The t-value was determined to be 2.416, while the t-value based on degrees of freedom (df) was 1.670 for a significance level of 0.05. Since the t-value is greater than the t-value (2.416>1.671). Therefore, it can be concluded that YouTube videos have a significant impact on seventh-grade students' ability of SMP Swasta Teladan Pematangsiantar to write procedural texts.

Classifying driver mutations of papillary thyroid carcinoma on whole slide image: an automated workflow applying deep convolutional neural network.

Informative biomarkers play a vital role in guiding clinical decisions regarding management of cancers. We have previously demonstrated the potential of a deep convolutional neural network (CNN) for predicting cancer driver gene mutations from expert-curated histopathologic images in papillary thyroid carcinomas (PTCs). Recognizing the importance of whole slide image (WSI) analysis for clinical application, we aimed to develop an automated image preprocessing workflow that uses WSI inputs to categorize PTCs based on driver mutations. Histopathology slides from The Cancer Genome Atlas (TCGA) repository were utilized for diagnostic purposes. These slides underwent an automated tile extraction and preprocessing pipeline to ensure analysis-ready quality. Next, the extracted image tiles were utilized to train a deep learning CNN model, specifically Google's Inception v3, for the classification of PTCs. The model was trained to distinguish between different groups based on BRAFV600E or RAS mutations. The newly developed pipeline performed equally well as the expert-curated image classifier. The best model achieved Area Under the Curve (AUC) values of 0.86 (ranging from 0.847 to 0.872) for validation and 0.865 (ranging from 0.854 to 0.876) for the final testing subsets. Notably, it accurately predicted 90% of tumors in the validation set and 84.2% in the final testing set. Furthermore, the performance of our new classifier showed a strong correlation with the expert-curated classifier (Spearman rho = 0.726, p = 5.28 e-08), and correlated with the molecular expression-based classifier, BRS (BRAF-RAS scores) (Spearman rho = 0.418, p = 1.92e-13). Utilizing WSIs, we implemented an automated workflow with deep CNN model that accurately classifies driver mutations in PTCs.

Timing of testing affects earwitness memory.

The present experiments investigated how interpolated testing and postevent misinformation affected earwitness memory. We examined how the number of tests and when tests occurred affected memory for an overheard event and source monitoring. Across three experiments, participants overheard a crime (i.e., the witnessed event), heard a news report summarizing the crime (postevent information), took a cued-recall test, and lastly, took a source-monitoring test. Experiment 1 compared three groups: repeated cued-recall test, repeated listen, single cued-recall test. Participants in the interpolated test group received a test after the witnessed event and again after the postevent information. Participants in the repeated listen group heard the witnessed event, and immediately relistened to the event before being presented with the postevent information. In Experiment 2 and 3, we varied the retention intervals between the witnessed event and the postevent information in a repeated test context. Our findings suggest that when participants took a test before presentation of the postevent information, they were less accurate on a final cued-recall test of the witnessed event. Importantly, the timing of the first test in relation to the witnessed event and postevent information differentially affected memory for the witnessed event and source monitoring of event and postevent details.