The article explores the main theoretical aspects of managing sustainable innovative development in the field of waste use. The role of the sphere of drug abuse in national security and in the economic potential of the country has been determined. Features of state regulation in this area were considered. The need is justified and the main directions for improving management in the field of waste use are defined. The essence of the concept of “nadrum” has been studied and the main users of nadrum in Ukraine have been identified. The essence of the concept of “overuse” and the specificity of its application was studied. The main stakeholders in the field of drug abuse have been identified and the need for coordination of their interests has been determined in order to build effective management mechanisms in this area. The essence of development is considered and key aspects that have an impact on the economy are identified, such as: extraction of natural resources; environmental protection; green economy; innovation and technology; investment; international cooperation; use of European standards; transparency and public participation and others. The place of innovation in the development of the sphere of drug abuse has been determined. The essence of sustainable development and its specifics in the field of drug abuse were considered. It is determined that innovation is the basis of sustainable development in the field of drug abuse. Innovations in the field of waste use allow to optimize the use of inks, reducing the costs of their research and development. Features of the sphere of misuse as an object of management were considered. It was noted that in order to be effective, management of sustainable innovative development in the field of waste use must be a systemic and holistic process. The specifics of management of sustainable innovative development in the field of drug use are identified and the main stages of implementation of this process are considered. It is justified the need to introduce the principles of sustainable innovative development in the sphere of non-exploitation to improve the effectiveness of its functioning.