In this study, high fidelity finite element (FE) model was adopted to investigate the progressive collapse resistance of reinforced concrete (RC) frame structures under various column removal scenarios. The validity of the numerical model was verified by comparing with the existing experimental results. Afterwards, to facilitate the research on possible simplified boundary conditions served for further various column removal scenarios, the effect of multi-span continuous beams was firstly evaluated and the simplified methods were compared. Then, the effect of various column removal scenarios addressing the three-dimensional effect on the progressive collapse resistance of RC frame structures with and without slab was systematically evaluated. The analysis results showed that the continuous span beams increased the internal compressive force of the beam section at compressive arch action (CAA) stage, which effectively improved the CAA strength of the substructure. For simple modeling, the use of horizontal constraints at the end of the beam could replace the continuous span beams. The presence of transverse beams and slab provided additional load transfer paths for collapse resistance. The compressive membrane action (CMA) and tensile membrane action (TMA) of the slab significantly improved the progressive collapse resistance of the substructure in the small and large deformation stages, respectively. The location of the removed column significantly affected the contribution ratio of transverse beams and slab to the progressive collapse resistance of the substructure, which was quantitatively evaluated for practical design.
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