This paper discusses the iteration of a seismic retrofit solution for shear-deficient end regions of 19 reinforced concrete (RC) moment-resisting frame (MRF) T-beams located in a 12-story RC MRF building in downtown Los Angeles, California. Local strengthening with externally bonded (EB) fiber-reinforced polymer (FRP) fabric was chosen as the preferred retrofit strategy due to its cost-effectiveness and proven performance. The FRP-shear-strengthening scheme for the deficient end-hinging regions of the MRF beams was designed and evaluated through large-scale cyclic testing of three replica specimens. The specimens were constructed at 4/5 scale and cantilever T-beam configurations with lengths of 3.40 m or 3.17 m. The cross-sectional geometry was 0.98 × 0.61 m with a top slab of 1.59 m in width and 0.12 m in thickness. Applied to these specimens were three different retrofit configurations, tested sequentially, namely: (a) unanchored continuous U-wrap; (b) anchored continuous U-wrap with conventional FRP-embedded anchors at the ends; and (c) fully closed external FRP hoops made of discrete FRP U-wrap strips and FRP through-anchors that penetrate the top slab and connect both ends of the FRP strips, combined with intermediate crack-control joints. The strengthening concept with FRP hoops precluded the premature debonding and anchor pullout issues of the two more conventional retrofit solutions and, despite a more challenging and labor-intensive installation, was selected for the in-situ implementation. The proposed hooplike EB-FRP shear-strengthening scheme enabled the deficient MRF beams to overcome a 30% shear overstress at the end-yielding region and to develop high-end rotations (e.g., 0.034 rad [3.4% drift] at peak and 0.038 rad [3.8% drift]) at strength loss for a beam that, otherwise, would have prematurely failed in shear. These values are about 30% larger than the ASCE 41 prescriptive value for the Life Safety (LS) performance objective. Energy dissipation achieved with the fully closed scheme was 108% higher than that of the unanchored FRP U-wrap and 45% higher than that of the FRP U-wrap with traditional embedded anchors. The intermediate saw-cut grooves successfully attracted crack formation between the strips and away from the FRP reinforcement, which contributed to not having any discernable debonding of the strips up to 3% drift. This paper presents the experimental evaluation of the three large-scale laboratory specimens that were used as the design basis for the final retrofit solution.