Precisely forecasting how concrete reinforced with fiber-reinforced polymers (FRP) responds under compression is essential for fine-tuning structural designs, ensuring constructions fulfill safety criteria, avoiding overdesigning, and consequently minimizing material expenses and environmental impact. Therefore, this study explores the viability of gradient boosting regression tree (GBRT), random forest (RF), artificial neural network-multilayer perceptron (ANNMLP) and artificial neural network-radial basis function (ANNRBF) in predicting the compressive behavior of fiber-reinforced polymer (FRP)-confined concrete at ultimate. The accuracy of the proposed machine learning approaches was evaluated by comparing them with several empirical models concerning three different measures, including root mean square errors (RMSE), mean absolute errors (MAE), and determination coefficient (R2). In this study, the evaluations were conducted using a substantial collection of axial compression test data involving 765 circular specimens of FRP-confined concrete assembled from published sources. The results indicate that the proposed GBRT algorithm considerably enhances the performance of machine learning models and empirical approaches for predicting strength ratio of confinement (f′cc/f′co) by an average improvement in RMSE as 17.3%, 0.65%, 66.81%, 46.12%, 46.31%, 46.87% and 69.94% compared to RF, ANNMLP, ANNRBF, and four applied empirical models, respectively. It is also found that the proposed ANNMLP algorithm exhibits notable superiority compared to other models in terms of reducing RMSE values as 9.67%, 11.29%, 75.11%, 68.83%, 73.64%, 69.49% and 83.74% compared to GBRT, RF, ANNRBF and four applied empirical models for predicting strain ratio of confinement (εcc/εco), respectively. The superior performance of the GBRT and ANNMLP compared to other methods in predicting the strength and strain ratio confinements is important in evaluating structural integrity, guaranteeing secure functionality, and streamlining engineering plans for effective utilization of FRP confinement in building projects.