B-cell acute lymphoblastic leukemia (B-ALL) is a hematologic malignancy commonly found in pediatric patients. This study aims to screen hub genes in B-ALL and elucidate the role of peroxiredoxin 1 (PRDX1) in the modulation of ferroptosis. Bioinformatics analyses were conducted to identify pivotal genes in the GSE17703 and GSE48558 datasets. The biological effects of PRDX1 deletion in B-ALL cells and the xenograft tumor were evaluated using a series of functional assays. Ferroptosis was induced in B-ALL cells using erastin. Transcriptome sequencing was performed on Nalm-6 cells before and after PRDX1 knockdown. Forskolin was employed to explore the role of PRDX1 in the cyclic adenosine monophosphate (cAMP) pathway. Four pivotal genes were identified, with two genes upregulated and two downregulated. Depletion of PRDX1 suppressed the proliferative, migratory, and invasive abilities of B-ALL cells, whereas PRDX1 overexpression exerted the opposite effects. PRDX1 silencing promoted erastin-induced ferroptosis, including elevated levels of COX2, ACSL4, ferrous ions, ROS, and MDA, while reducing GPX4, GSH, and SOD levels. PRDX1 knockdown further reduced the viability of B-ALL cells treated with the ferroptosis activator ML210, and treatment with the ferroptosis inhibitor liproxstatin-1 significantly reversed the suppressive effect of PRDX1 knockdown on xenograft tumor growth. Mechanically, PRDX1 deletion triggered ferroptosis in B-ALL cells by inhibiting the cAMP pathway. PRDX1 deficiency modulates ferroptosis in B-ALL cells by blocking the cAMP pathway, which offer a novel perspective on the pathogenesis of B-ALL.

Lactic acid bacteria (LAB) are known for their health benefits, which are isolated frequently from various fermented foods. This study aimed to evaluate the safety, metabolite production, antioxidant, and antibacterial activity of LAB isolated from Chinese traditional cheese and their application in fermented dairy products. According to 16S rRNA sequence analysis, seven LAB strains were identified as Lactococcus lactis W3A and W3C, Streptococcus lutetiensis W3B, Enterococcus durans W3D, Leuconostoc mesenteroides W3E, Enterococcus lactis W3F, and Leuconostoc lactis W3J, respectively. Hemolysis and antibiotic sensitivity tests showed that all strains were safe for consumers. Meanwhile, all strains showed a good ability to produce exopolysaccharide (330.57–1097.10 mg L−1) and organic acid (31.83–65.43 g L−1). The antioxidant assay indicated that seven LAB strains could effectively scavenge DPPH (37.72–53.13%), ABTS+ (95.86–98.67%), ·OH (86.06–95.26%), ·O2− (11.88–31.30%) free radicals, and chelate ferrous ion (23.98–54.70%) and could reduce ferric ions (35.56–273.14 μmol L−1). In addition, they also displayed different antibacterial activity (10–30 mm inhibition zone) against all 13 foodborne pathogenic bacteria. Finally, the two best strains (Leu. lactis W3J and E. lactis W3F) were selected with PCA and EW-TOPSIS methods and used to ferment goat milk. Fermented samples provided a stronger antioxidant ability than the unfermented goat milk. The results suggested that these two LAB strains had potential applications in antioxidant foods.

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Innovative advanced processes for treatment of multiple emerging pesticides from water: Performance, statistical design, QuEChERS-GC-MS/MS sensitive identification and degradation mechanism.

Lycium barbarum alleviates oxidative stress-induced ferroptosis and enhances mitophagy in intervertebral disc degeneration.

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Remediation of sulfamethoxazole contaminated soil using sulfidated zero-valent iron: The overlooked size and sulfur content effects.

Enhanced bioleaching of spent lithium-ion battery cathode powder by Acidithiobacillus ferroxidans for selective metal recovery: Influence of ferrous iron and elemental sulfur as energy sources

Eldecalcitol ameliorates type 2 diabetic osteoporosis by attenuating endothelial ferroptosis via the SOCE/O-GlcNAcylation axis.

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Tailored mechano-responsive micelles mimic the iron starvation response and impair pH homeostasis for triggered cancer therapy.

Combined use of vitamin C and antifolates induces cuproptosis-like bacterial death.