Femoral Strength Index Research Articles

Nordic walking with an integrated resistance shock absorber affects the femur strength and muscles torques in postmenopausal women

Deterioration of the structure and function of the musculoskeletal system represents a significant problem during aging and intervention with a suitable load of physical activity may improve the quality of life. Nordic walking (NW) has become a popular and easily accessible form of activity, especially for older adults people around the world. Thus, the purpose of the study was to evaluate the influence of an Nordic walking training program with classic poles (NW) and with integrated resistance shock absorber (RSA) on bone mineral density and the peak torques of upper limb muscles and to compare the effects of both intervention programs. 25 women were randomly assigned to two training groups: 10 subjects using RSA (68 ± 4.19 years) and 15 subjects using NW poles (65 ± 3.40 years), which completed 8 weeks of training program. The hip, spine and forearm areal bone mineral density, torques of the flexors and extensors at the elbow and shoulder joints were measured before starting the training programs and after their completion. The most significant effect was found in differences between the two groups of women with respect to the femur strength index (p = 0.047) and the ratio of the flexors to extensors in the elbow (p = 0.049) and shoulder (p = 0.001) joints and peak torque of flexors in the shoulder joint (p = 0.001) for the left arm. A significant difference was also found in the index of torque asymmetry of flexors in the shoulder joint (p = 0.002). The study shows that Nordic walking with RSA poles for postmenopausal women led to beneficial changes in the femur strength index. However, we found no significant influence on bone mineral density values measured on the whole body, the femoral neck, forearm or lumbar spine regions. The occurrence of asymmetry in biomechanical muscle parameters, which was observed using RSA poles, may suggest the necessity of systematic controlling the gait technique to avoid the adverse consequences of asymmetrical rotation of the lumbar spine.

Positive association of lean mass and negative association of protein intake on bone mass and bone geometry of adolescent soccer players

ObjectiveThe aim of this study was to evaluate the association of food consumption and body composition on bone parameters in adolescent soccer players. MethodsThere were 148 male soccer players 12 to 18 y who participated in the study. Body composition was assessed by dual energy x-ray absorptiometry, comprising bone mineral density (BMD) and bone mineral content (BMC) of total body without head (TBLH), lumbar spine (L1-L4), and right femoral neck (RFN). The bone geometry variables measured were femoral strength index (FSI), buckling ratio (BR), section modulus (Z), cross-sectional moment of inertia (CSMI), and cross-sectional area (CSA). Food intake was analyzed using the 24-h food recall. Somatic maturation was estimated by the peak height velocity equation. For the statistical analysis, the stepwise multiple linear regression was used, with P < 0.05. ResultsRegarding food consumption, there was a high protein intake and low calcium intake. Lean mass was a predictor of BMC of TBLH (R2 = 0.524), L1-L4 (R2 = 0.492), and RFN (R2 = 0.405); BMD of L1-L4 (R2 = 0.407) and RFN (R2 = 0.27); Z (R2 = 0.683), CSMI (R2 = 0.630), and CSA (R2 = 0.640). There was a negative correlation between protein intake with bone mass and bone geometry parameters. ConclusionIn adolescent soccer players, lean mass was a predictor of bone parameters, and high protein intake was negatively associated with bone mass and geometry.

The Impact of Major and Trace Elements in Serum and Bone on Dual-Energy X-Ray Absorptiometry-Derived Hip Strength

The purpose of this study was to establish associations between both serum levels and bone content of a wide range of elements (Na, K, P, Ca, Mg, Zn, Cu, Cr, Mn, Fe, and Pb), with hip strength (HS) indices derived from dual-energy X-ray absorptiometry (DXA). The study population consisted of a number of male patients aged 56–77 years following hip replacement due to osteoarthritis of the hip. Bone specimens were taken from the femoral head and neck during arthroplasty. The elemental analyses were carried out using coupled plasma optical emission spectrometry. The following DXA-HS parameters were assessed: buckling ratio (BR), cross-sectional area (CSA) and its moment of inertia (CSMI), section modulus, and Femoral Strength Index (FSI). Age was positively correlated with Na, K, and Cu in the bone. Ca in the bone was positively associated with BR and negatively with SM and CSMI. Of all the DXA-HS parameters, the weakest associations of elements in the bone were found with FSI and the strongest with BR. Among the elements in the serum, the strongest negative associations were found for K, Cr, Mn, and Zn with CSA, while the majority of bone elements were associated either positively (Ca, P, Mg, Zn, and Cu) or negatively (Mn, Fe, Pb, and Cr) with BR. In conclusion, the interactions between individual elements in blood serum and bone with DXA-HS could not be unequivocally established.

Can the sedentary behavior of basketball and volleyball players impact bone mass and bone geometry?

The aim of the study was to evaluate the relationship between sedentary behavior, bone mass, and bone geometry among young male basketball and volleyball players. This cross-sectional study included 55 adolescent basketball ( n = 21) and volleyball ( n = 34) players (14–17 years). Body composition (body mass index, fat mass, and lean mass) was measured by dual-energy X-ray absorptiometry, comprising bone mineral density, bone mineral content at the lumbar spine, and femoral neck. Bone geometry considered the femur strength index, section modulus, cross-sectional moment of inertia, and cross-sectional area. Dietary intake was obtained through a semiquantitative questionnaire, and the sedentary behavior, by the Adolescent Sedentary Activity Questionnaire. Linear regression models, fitted by Bayesian methods, explored the variation of the variables by sport. Body composition and bone mass values were high for both sports, but there was no variation for body composition. Adjusting for age, there was no association of sedentary behavior on bone parameters. For femoral strength index, age had a moderate to large association with all bone indicators. Lastly, there was influence of sport (level-2 unit) on the estimates of the association between sedentary behavior and age with bone indicators, as uncertainty estimates for group-level effects were high. There is no association between sedentary behavior and bone parameters, showing that accumulated training loads (15+ h/wk) among young basketball and volleyball players are critical; producing a positive stimulus on bone parameters development.

Референтні показники структурного аналізу стегнової кістки в жінок української популяції

Актуальність. На сьогодні комплексна оцінка стану кісткової тканини та ризику остеопоротичних переломів передбачає спільне використання показників мінеральної щільності кісткової тканини (МЩКТ), 10-річної ймовірності основних остеопоротичних переломів (Fracture Risk Assessment Tool, FRAX), показника трабекулярної кістки (Trabecular Bone Score, TBS) і параметрів структурного аналізу стегнової кістки (Hip Structural Analysis, HSA). Останніми роками створено референтні показники для осіб української популяції щодо трьох вищезазначених методик, проте дані щодо останньої методики відсутні. Мета дослідження: вивчити вікові особливості параметрів структурного аналізу стегнової кістки в жінок української популяції та запропонувати їх референтні показники для використання в практичній охороні здоров’я. Матеріали та методи. За допомогою методики двохенергетичної рентгенівської абсорбціометрії обстежено 690 умовно здорових жінок віком 20–89 років без остеопорозу, інших клінічно значущих захворювань та станів, що впливають на метаболізм кісткової тканини, без супутньої патології кульшового суглоба тощо. Результати. Результати проведеного дослідження продемонстрували вірогідний вплив віку на показники FSI, CSMI, CSA, d1, d2, d3, y, α і HAL, проте не на показник θ. Встановлено вірогідне зменшення з віком показника FSI на тлі вірогідного зростання параметрів CSMI, CSA та HAL. Показники зросту та маси тіла були вірогідно пов’язані з параметрами CSMI, CSA і HAL. Показник міцності стегнової кістки (FSI) був вірогідно пов’язаний з масою тіла, проте не зі зростом. Крім того, він вірогідно корелював з показником МЩКТ, виміряним на рівні шийки стегнової кістки і меншою мірою на рівні всієї стегнової кістки та поперекового відділу хребта. Показник довжини осі стегнової кістки (HAL) вірогідно не корелював з жодним вимірюваним показником МЩКТ, що підтверджує його незалежну роль у прогнозуванні ризику переломів стегнової кістки. Висновки. Отримані нормативні показники структурного аналізу стегнової кістки в здорових жінок української популяції можуть бути використані для комплексної оцінки стану кісткової тканини та ризику переломів стегнової кістки.

Geometric indices of femur bone strength in female handball players

ABSTRACT The practice of sports during the growth phase has a positive influence on bone mineral accrual. However, the effects of different sports are still not fully understood. The aim of this study was to evaluate the bone geometry in adolescent handball players. This is a cross-sectional study in which 53 female adolescents (12–17 years old) were divided into two groups: handball players (HG: n = 26), who must have had at least six months of participation in official competitions, and a control group (CG: n = 27). Bone geometry properties, such as cross-sectional area (CSA), cross-sectional moment of inertia (CSMI), section modulus (Z), and femoral strength index (FSI) were measured using DXA. Tanner’s sexual maturity, menarche, peak height velocity, sun exposure, and calcium intake were assessed. An unpaired Student’s t test or the Mann-Whitney test and multivariate analyzes were used to compare variables differences between groups. The HG group showed a significantly higher body mass index, weight and lean mass (LST), CSA, CSMI, Z, and FSI than the CG group. When the values were adjusted for LST, the differences disappeared. The LST has been shown to be relevant to the strength and bone stiffness of the femurs of female adolescents, and the competitive practice in handball may have contributed to its increase.

Bone Mineral Density and Bone Turnover Markers in Postmenopausal Women Subjected to an Aqua Fitness Training Program.

The purpose of this study was to analyze the influence of aqua fitness training in deep water on bone tissue. The study was performed with 18 postmenopausal women separated into two groups: training and control groups. Before and after the training program, the hip and spine areal bone mineral density were measured along with the biochemical parameters of serum concentration of osteocalcin (OC) and C-terminal telopeptide of type I collagen (CTX). The most significant effect was found in differences between the two groups of women in terms of femur strength index (p < 0.05) during the period of the training program. The study demonstrated that an aqua fitness training program caused favorable changes in femur strength index in postmenopausal women, and this kind of exercise could be a useful form of physical activity for postmenopausal women.

Bone Density and Cross-sectional Geometry of the Proximal Femur Are Bilaterally Elevated in Elite Cricket Fast Bowlers

The skeleton of a cricket fast bowler is exposed to a unique combination of gravitational and torsional loading in the form of substantial ground reaction forces delivered through the front landing foot, and anterior-posterior shear forces mediated by regional muscle contractions across the lumbo-pelvic region. The objectives of this study were to compare the hip structural characteristics of elite fast bowlers with recreationally active age-matched controls, and to examine unilateral bone properties in fast bowlers. Dual-energy X-ray absorptiometry of the proximal femur was performed in 26 elite male fast bowlers and 26 normally active controls. Hip structural analysis (GE Lunar; enCORE version 15.0) determined areal bone mineral density (BMD) of the proximal femur, and cross-sectional area, section modulus (Z), cross-sectional moment of inertia, and femoral strength index at the narrow region of the femoral neck. Mean femoral neck and trochanter BMD were greater in fast bowlers than in controls (p < 0.001). All bone geometry properties, except for cross-sectional moment of inertia, were superior in fast bowlers (p < 0.05) following adjustment for height and lean mass. There were no asymmetries in BMD or bone geometry when considering leg dominance of the fast bowlers (p > 0.05). Elite fast bowlers have superior bone characteristics of the proximal femur, with results inferring enhanced resistance to axial compression (cross-sectional area), and bending (Z) forces, and enhanced strength to withstand a fall impact as indicated by their higher femoral strength index. No asymmetries in hip bone properties were identified, suggesting that both torsional and gravitational loading offer significant osteogenic potential.

Long-term effect of aromatase inhibitors on bone microarchitecture and macroarchitecture in non-osteoporotic postmenopausal women with breast cancer.

AIs increase the risk of fracture in patients with breast cancer. Therefore, we aimed to evaluate the long-term skeletal effects of AIs in postmenopausal women with primary breast cancer. We performed a retrospective longitudinal observational study in non-osteoporotic patients with breast cancer who were treated with AIs for ≥3years (T-score >-2.5). Patients with previous anti-osteoporosis treatment or those who were given bisphosphonate during AI treatment were excluded from the analysis. We serially assessed BMD, lumbar spine TBS, and hip geometry using dual-energy X-ray absorptiometry. BMD significantly decreased from baseline to 5years at the lumbar spine (-6.15%), femur neck (-7.12%), and total hip (-6.35%). Lumbar spine TBS also significantly decreased from baseline to 5years (-2.12%); this change remained significant after adjusting for lumbar spine BMD. The annual loss of lumbar spine BMD and TBS slowed after 3 and 1year of treatment, respectively, although there was a relatively constant loss of BMD at the femur neck and total hip for up to 4years. The cross-sectional area, cross-sectional moment of inertia, minimal neck width, femur strength index, and section modulus significantly decreased, although the buckling ratio increased over the treatment period (all P<0.001); these changes were independent of total hip BMD. Long-term adjuvant AI treatment negatively influenced bone quality in addition to BMD in patients with breast cancer. This study suggests that early monitoring and management are needed in non-osteoporotic patients with breast cancer who are starting AIs.

Bone microarchitecture involvement and intervertebral disc alterations in patients with β-thalassemia: a retrospective study

Background. Bone involvement in patients with β-thalassemia is well known, but only few studies have analyzed bone microarchitecture and the prevalence of intervertebral disc calcifications (IDCs) in these patients.Aim: to evaluate the bone involvement in a group of patients with β-thalassemia in terms of geometry and bone quality; moreover, we evaluated prevalence and site of IDCs in these patients.Methods. Our retrospective case-control study was conducted in a population of adults with β-thalassemia, aged between 18 and 50 years. The patients were divided, according with the International Society for Clinical Densitometry, into 2 groups: subjects with Zs ≤ -2.0, below the expected range for age, and subjects with Zs &gt; -2.0, within the expected range for age. Assessment of proximal femur geometry was performed using the Hip Structural Analysis (HSA), that provides the following parameters: Hip Axis Length (HAL), Femoral Strength Index (FSI), Cross-Sectional Moment of Inertia (CSMI) Cross-Sectional Area (CSA), Section Modulus (Z), and buckling ratio (BR). Assessment of bone quality was performed using the Trabecular Bone Score (TBS), stratifying subjects into 3 groups: with abnormal (TBS ≤ 1.200), partially altered (TBS&gt; 1.200 and &lt;1.350), and normal (TBS ≥ 1.350) trabecular microarchitecture. Finally, we evaluated the prevalence of IDCs highlighted by images of Vertebral Fracture Assessment (VFA).Results. We evaluated 49 patients with β-thalassemia, mean aged 35.16 ± 9.59 years, divided into two groups: 25 patients with Zs ≤ -2.0 and 24 patients with Zs &gt; -2.0. Results demonstrated all statistically significant differences (p&lt;0.001) between the two groups in BMD, Ts and Zs (in all examined districts), and in number of fragility fractures (p=0.0339). HSA showed that there are significant differences between groups only in FSI (p=0.0068) and CSA (p=0.0041). Furthermore, TBS of patients with Zs ≤ -2.0 was significantly lower than individuals Zs &gt; -2.0 (p=0.0006); there was a statistically significant difference between the two groups in categorized TBS (p=0.0061). Finally, we evidenced in 7 patients (14.29%) the presence of at least one IDC.Conclusions. Our results showed that β-thalassemia is characterized not only by a reduction in BMD, but also by a geometric and qualitative bone microarchitecture involvement. HSA and even more TBS should be included in the assessment of individuals with β-thalassemia, in order to obtain a proper management and prevention of fragility fractures; furthermore, the presence of IDCs might be better investigated in these patients.

Hip structure analysis by DXA of teriparatide treatment: A 24-month follow-up clinical study

ObjectiveThe objective of this study was to perform a hip structure analysis (HSA) of teriparatide (TPTD) treatment in women with postmenopausal osteoporosis. MethodsThe study included 96 patients with postmenopausal osteoporosis and received 20μg TPTD daily. HSA was performed by dual-energy X-ray absorptiometry. ResultsThe percent changes from baseline for the cross-sectional moment of inertia, section modulus, buckling ratio, and femoral strength index based on HSA results were 9.8% (p<0.01), 10.7%, 3.3%, and 14.9% (p<0.01), respectively, at 24 months. ConclusionBased on the HSA results obtained with DXA, TPTD was effective for hip structures.

Associations of Body Mass Index With Incident Fractures and Hip Structural Parameters in a Large Canadian Cohort.

Fractures in obese individuals are of public health importance, but the relationship between obesity and fracture is complex and remains poorly understood. The study examined the association of body mass index (BMI) with bone structural and strength parameters and incident fracture. We performed cross-sectional and longitudinal analyses using data from the Manitoba Bone Density Program. We included 51 313 women and 4689 men aged 50 years or older referred for dual-energy X-ray absorptiometry scans. For 41 919 women and 4085 men, we were able to derive hip structural parameters. Cross-sectional moment of inertia, cross-sectional area, and femoral strength index were derived from dual-energy X-ray absorptiometry. Health service records were assessed for incident major osteoporotic fractures (MOFs) (mean follow-up 6.2 y in women and 4.7 y in men). Among individuals with a BMI of less than 30 kg/m(2), increasing BMI was associated with progressive increases in bone mineral density (BMD), cross-sectional moment of inertia, and cross-sectional area. The relationship reached a plateau around a BMI of 30 kg/m(2), with little additional increment with further increases in BMI (all P for interaction < .0001, obese vs nonobese). Increasing BMI was linearly associated with decreases in strength index in both women and men. MOFs were ascertained in 3721 women and 276 men (1027 female and 75 male hip fractures). Higher BMI was associated with a lower risk of MOF in women in multivariable models, but this association was largely explained by their higher BMD. Protective association of higher BMI with hip fracture were stronger and only partially explained by BMD (hazard ratio [95% confidence interval] 0.79 [0.73-0.99] for obese I and 0.67 [0.46-0.98] for obese II). Higher BMI was not significantly associated with a risk of MOF or hip fracture in men. Despite structural and biomechanical disadvantages, obese women were at lower risk of fracture.

Proximal femur geometry assessed by hip structural analysis in hip fracture in women.

In the pathogenesis of hip fracture, proximal femur geometry plays a key role as well as decreased bone density. The hip structural analysis (HSA) processes dual energy X-ray absorptiometry (DXA) images containing information on the geometry closely related to the strength of the proximal femur. The objective of this study was to investigate bone mineral density (BMD) and mechanical properties of the proximal femur in a group of women with a previous contralateral hip fragility fracture compared to women without history of hip fracture. In a population of postmenopausal women, we evaluated bone density by DXA and bone geometry using the HSA parameters (femoral strength index, cross-sectional moment of inertia, cross-sectional area, section modulus, and buckling ratio) including hip axis length (HAL) and neck shaft angle. Of a total of 62 postmenopausal women, twenty-six with a history of hip fracture had a mean femoral neck BMD significantly lower in comparison with 36 women in the control group (0.703 versus 0.768 g/cm(2), p = 0.0347). There was a statistically significant difference between groups also for HAL (106.75 mm in fracture group versus 100.93 mm in control group, p = 0.0015). Our results demonstrated that all the geometrical parameters resulted worst into the group of patients with history of hip fracture, even though only the HAL was significantly lower in control subjects. In our opinion HSA is useful to characterize the risk of hip fracture in postmenopausal women, providing additional data on the spatial distribution of bone mass strongly related to bone strength.

Five-Year Experience with Risedronate Therapy for Patients with Increased Fracture Risk: A Practice-Based Observational Study

The purpose of this practice-based observational study was to examine the effects of long-term treatment with risedronate in patients with an increased fracture risk. Seventy patients (4 men and 66 postmenopausal women; mean age, 68.0 years) with osteoporosis or osteopenia and clinical risk factors for fractures were treated with risedronate at either 2.5 mg/d or 17.5 mg/week for 5 years. The bone mineral density (BMD) of the lumbar spine and proximal femur, and the structural geometric parameters of the proximal femur were evaluated by dual-energy X-ray absorptiometry with advanced hip assessment software at baseline and after each year of treatment. The lumbar spine BMD rapidly increased during the first year of the treatment and steadily increased throughout the 5-year treatment period. The BMD of the femoral neck and total hip also significantly increased during the first 3 and 2 years of treatment, respectively, then gradually declined and reached the baseline level after 5 years of treatment. The cross-sectional moment of inertia, cross-sectional area, and mean width of the femoral neck region of interest significantly increased during the first 2 years, and these increases were maintained throughout the 5-year treatment period. The femur strength index and section modulus also significantly increased following time courses similar to those of the above three parameters. These results suggest that risedronate produced both a sustained increase in the lumbar spine BMD and improvement in the femoral structural geometric parameters for 5 years of treatment.

E-15 Thematic Poster - Aging and Skeletal Muscle

PURPOSE: The Bone-Specific Physical Activity Questionnaire (BPAQ) was designed to provide researchers with a tool to control the previous bone-relevant exercise history of participants enrolled in bone-targeted exercise intervention trials. We sought to determine whether short-term changes in BPAQ score induced by a 9-month bone-targeted intervention would correspond to changes in markers of bone strength in premenopausal women. METHODS: 391 women (age 23.4±4.5 y, BMI 22.7±2.7 kg/m2) were randomized into 9 jumping groups representing three jump heights (4, 8, or 12-inch step) and three jump repetition schemes (10, 50, 100 jumps per session) or a control group. Subjects stepped up and jumped off of a step for their required reps 3 d/wk for 9 months. Femoral neck bone mineral density (FN BMD) and Femoral Strength Index (FSI) (a computed surrogate of bone strength that takes into account bone geometry and BMD of the hip) of bilateral proximal femurs using DXA (Lunar Prodigy Advance) and BPAQ scores were measured at baseline and after the 9-month intervention. Ground reaction force and loading rate were determined every 3 months via force platform (Kistler). An average effective load stimulus for each step height used for jumping was determined using the BPAQ algorithms described by Weeks & Beck (2008). PPM correlation coefficients were determined for percent change in BMD and FSI vs percent change in BPAQ score. RESULTS: The 211 subjects (54%) who jumped at least 2 days/wk and completed all measurements were included in the analyses. Bone at the proximal femur responds well to low loading volume in that as few as 25 jumps/wk at a magnitude of 3 times body weight improves FSI by 9% although higher impacts may negatively impact bone (details presented elsewhere). While the pre- and post-test values for FN BMD and FSI correlated positively with BPAQ scores (r=0.18, r=0.14 and r=0.17, respectively, p<0.05), percent change in FN BMD and FSI was not related to percent change in BPAQ score during the intervention. CONCLUSIONS: Absolute BPAQ score was related to FN BMD and FSI before and after the intervention, but percent change in BPAQ score was not related to percent change in bone parameters. The BPAQ may be insufficiently sensitive to detect very modest short term change in parameters of bone strength. Supported by NIH SC3GM08705

Hip structural parameters over 96 weeks in HIV-infected adults switching treatment to tenofovir-emtricitabine or abacavir-lamivudine.

BackgroundTherapy with tenofovir is associated with lower bone mineral density (BMD), higher markers of bone turnover and increased fracture risk in HIV-infected adults. Bone structural parameters generated by hip structural analysis may represent a separate measure of bone strength, but have not been assessed in HIV.MethodsDual-energy X-ray absorptiometry (DXA) scans from 254 HIV-infected adults randomised to simplify their existing dual nucleoside analogue reverse transcriptase inhibitor therapy to coformulated tenofovir-emtricitabine or abacavir-lamivudine were analysed using DXA-derived hip structural analysis software. Hip structural parameters included femoral strength index, section modulus, cross-sectional area, and cross-sectional moment of inertia. We used one-way ANOVA to test the relationship between nucleoside analogue type at baseline and structural parameters, multivariable analysis to assess baseline covariates associated with femoral strength index, and t-tests to compare mean change in structural parameters over 96 weeks between randomised groups.ResultsParticipants taking tenofovir at baseline had lower section modulus (−107.3 mm2, p = 0.001), lower cross-sectional area (−15.01 mm3, p = 0.001), and lower cross-sectional moment of inertia (−2,036.8 mm4, p = 0.007) than those receiving other nucleoside analogues. After adjustment for baseline risk factors, the association remained significant for section modulus (p = 0.008) and cross-sectional area (p = 0.002). Baseline covariates significantly associated with higher femoral strength index were higher spine T-score (p = 0.001), lower body fat mass (p<0.001), lower bone alkaline phosphatase (p = 0.025), and higher osteoprotegerin (p = 0.024). Hip structural parameters did not change significantly over 96 weeks and none was significantly affected by treatment simplification to tenofovir-emtricitabine or abacavir-lamivudine.ConclusionIn this population, tenofovir use was associated with reduced composite indices of bone strength as measured by hip structural analysis, but none of the structural parameters improved significantly over 96 weeks with tenofovir cessation.Trial RegistrationClinicalTrials.gov NCT00192634

Multivariate analysis of lifestyle, constitutive and body composition factors influencing bone health in community-dwelling older adults from Madeira, Portugal

This study describes the association between habitual physical activity (PA), other lifestyle/constitutive factors, body composition, and bone health/strength in a large sample of older adults from Madeira, Portugal.This cross-sectional study included 401 males and 401 females aged 60–79 years old. Femoral strength index (FSI) and bone mineral density (BMD) of the whole body, lumbar spine (LS), femoral neck (FN), and total lean tissue mass (TLTM) and total fat mass (TFM) were determined by dual-energy X-ray absorptiometry-DXA. PA was assessed during face-to-face interviews using the Baecke questionnaire and for a sub-sample by Tritrac accelerometer. Demographic and health history information were obtained by telephone interview through questionnaire.The relationship between habitual PA variables and bone health/strength indicators (whole body BMD, FNBMD, LSBMD, and FSI) investigated using Pearson product-moment correlation coefficient was similar for females (0.098≤r≤0.189) and males (0.104≤r≤0.105). Results from standard multiple regression analysis indicated that the primary and most significant predictors for FNBMD in both sexes were age, TLTM, and TFM. For LSBMD, the most significant predictor was TFM in men and TFM, age, and TLTM in females. Our regression model explained 8.3–14.2% and 14.8–29.6% of the total variance in LSBMD and FNBMD for males and females, respectively.This study suggests that habitual PA is minimally but positively associated with BMD and FSI among older adult males and females and that body composition factors like TLTM and TFM are the strongest determinants of BMD and FSI in this population.

THU0391 Is there a Relationship between Hip Structural Analysis and Bone Mineral Density at the Hip and Spine?

BackgroundHip structural analysis (HSA) has been suggested as possible method of improving prediction of hip fracture risk above that provided by current bone mineral density (BMD) use alone. To our...

SAT0344 Does proximal femur shape contribute to femoral neck fracture risk in osteoporotic individuals?

BackgroundHip Structural Analysis (HSA) has been used to investigate the relationship between proximal femoral neck shape and femoral neck fracture risk; studies have reported contrasting findings. Although previous work has...

SAT0364 Are differences of hip shape responsible for increased femoral neck fracture risk in post-menopausal women?

BackgroundStudies have identified the relationship between the menopause and femoral neck fracture risk. Recent research has implicated proximal femoral shape, measured using Hip Structural Analysis (HSA), in femoral neck fracture...