Objective To summarize the individualized design of perforating branches in the KISS flap of the descending branch of lateral femoral circumflex artery and improve the survival rate of flap. Methods From Septem-ber, 2012 to June, 2016, the individualized design KISS flap of perforating branches of lateral femoral circumflex artery was used to repair the soft defect in arms and legs in 20 cases, which contained 12 males and 8 females aged from 23 to 71 years old with an average of 48 years. The wounds in upper limb and wrist were 16 cases, and in instep and lower ex-tremity wounds were 4 cases. The areas of tissue defect were ranged from 8.5 cm×12.0 cm to 12.0 cm×23.0 cm. The area of flap ranged from 5.0 cm×8.0 cm to 8.0 cm×14.0 cm. Donor sites were sutured directly. Postoperative follow-up was done termly. Results All flaps survived without vascular crisis. The wounds and incisions at donor sites were the pri-mary healing. Seventeen cases were followed-up 6 to 24 months (average, 18 months) . The color and texture of the flaps were good, and the appearance was satisfactory. The donor site of the flap only left linear scar. Conclusion Designed KISS flap according to diameter of the perforator artery in the operation can improve the survival rate of the flap. The de-sign of the KISS flap is more flexible and reliable, which is worthy of promotion. Key words: Lateral femoral circumflex artery, descending branch; KISS flap; Wound repair; Personal-ized design