This study examines gender, geographic, and earnings inequalities within and across 13 health, education, and STEM (science, technology, engineering, and mathematics and computer science) professions in Canada. Data from the 2006 and 2016 population censuses were pooled and linked to a continuous geospatial remoteness index for assessing trends in occupational feminization and associated employment earnings among degree-holding professionals aged 25–54. Linear regression and Oaxaca-Blinder decomposition methods were used to analyze how personal, professional, and socioenvironmental factors may attenuate or magnify wage differentials by sex. Results show the STEM professions tended to remain male-dominated, heavily urbanized, and subject to significantly lower earnings for women compared to men. Other historically female-dominated professions, notably nursing professionals and secondary school teachers, were characterized with geographic distributions most closely approaching the general population, relatively narrower gender wage gaps, but also lower average annual earnings. A significant gender wage differential was found in each profession, with women earning 4.6‒12.5% less than men, after adjusting for traditional human capital measures, social characteristics intersecting with gender, and community remoteness and accessibility. Residential remoteness and census period generally explained little of the gender wage gap. Despite decades of pay equity policies in Canada, women’s earnings averaged 2.3‒7.9% less than men’s due to unexplained factors, a finding which may be attributed, at least in part, to persistent (unmeasured) gender discrimination even in highly educated professions.