The majority of research on opportunity entrepreneurship, defined as startups attempts based on perceived business opportunities, has been conducted in either high- or low-income countries. However, the characteristics of these types of entrepreneurship in middle-income countries are very scarce, especially in Latin America.
 The purpose of this paper was to analyze and compare the factors that influence opportunity entrepreneurship using the data obtained from the Global Entrepreneurship Monitor (GEM) (Adult Population Survey [APS], 2015), comparing the results between males and females in Mexico.
 The empirical research employs a logistic regression model. The main findings highlight that perceived capabilities, work status, income level, and age exert a positive influence on opportunity entrepreneurship, while the factors of fear of failure or education present exerting no influence on this type of venture. Also, the results show that there are no differences between males and females. The research contributes to an increasing literature of this phenomenon in one of the most important countries in this region.