Brain injury arising from head trauma is a major concern in mixed martial arts (MMA) because knockout (KO) and technical knockout (TKO) are frequent fight outcomes. Previous studies have shown a high incidence of matches ending due to strikes to the head but did not consider weight categories and female fights. This study aimed at analyzing match stoppages in MMA and the exposure to head trauma distinguished by sex and weight categories. The heavier the weight class, the greater the risk and incidence of head trauma will be, regardless of sex. Descriptive epidemiology study. Level 3. Publicly available data of 167 MMA events from 1903 fights between 2014 and 2017 were assessed, comprising 8 male and 2 female weight categories. The combined KO/TKO rates per 100 athlete-exposures in the middleweight (19.53), light heavyweight (20.8), and heavyweight (26.09) divisions were greater than previously reported for MMA. While stoppage via KO/TKO occurred in 7.9% of combats in the female strawweight division, it occurred in 52.1% of the male heavyweight fights. The male middleweight ( P = 0.001), light heavyweight ( P < 0.001), and heavyweight divisions ( P < 0.001) had an increased risk of KO/TKO due to strikes to the head by 80%, 100%, and 206%, respectively. The risk in the flyweight division decreased 62% ( P = 0.001). All categories were compared with the lightweight division. The female bantamweight category presented a 221% increased risk in matches ending due to KO/TKO compared with the strawweight division ( P = 0.012). Punches to the head were the major technique used to end a combat via KO/TKO, regardless of sex and weight class. Head injury risk and incidence varies considerably according to sex and weight category in MMA. The analysis of head trauma exposure in MMA athletes should be distinguished according to sex and weight category.
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