Feed Material Research Articles

Quality improvement of Tofu waste as the raw material of duck feed with fermentation of yeast culture

The use of fermented products from probiotic microbes as supplement feed is expected to stimulate the growth and biocontrol of pathogenic bacteria in ducks with high feed efficiency. Feed biotechnology products based on tofu waste fermented with yeast culture (TWF) contain high levels of protein and the amino acid lysine, and contain probiotic microbes (107cfu/g). This research aims to examine the effect of fermenting tofu waste with yeast culture on the quality of tofu waste as a feed ingredient and the performance of ducks. The fermented product was tested on 240 male Bali ducks aged 2 weeks in a completely randomized design with four treatments and six replications. Each replication used 60 male Balinese ducks with homogeneous body weight. The four treatments were ducks given rations without TWF supplements as control (TWF0); diet supplemented with 2% TWF (TWF1); diet fed 4% TWF (TWF2); and rations given 6% TWF (TWF3). The results showed that supplementation of 4-6 TWF in feed significantly (P<0.05) increased body weight gain and feed efficiency.It can be concluded that the growth performance and feed efficiency of ducks increased significantly with the supplement of tofu waste fermented by yeast culture.

Inactivation of Anisakis simplex Allergens in Fish Viscera by Acid Autolysis

The evisceration of infested species on board commercial fleets and the throwing of viscera into the sea, as is mostly the case for hake, is common practice for reducing the occurrence of Anisakis in fishery products. Moreover, the high levels of infestation and the lack of technically and economically feasible solutions hinder the possibility of recovering viscera with other fish processing byproducts as raw material for feed without the risk of transmission of allergens to humans, with the subsequent risk for public health. The aim of this work was to study the fate of Anisakis simplex allergens during 11 days of silage of infested hake (Merluccius merluccius) viscera, as a potential method for eliminating this risk. While the viscera were almost completely liquefied, an increase in the allergenicity of the soluble fraction was observed, which decreased only slightly after day 9. As we are aware of the resistance of parasite allergens to gastrointestinal enzymes, silage was also analyzed after 12 and 15 months. While the lower molecular weight fragments of Anisakis proteins are fully digested, some larger fragments with potential allergenicity resisted autolysis after long silage periods, but they were present in a very low concentration. The study concludes that there is the potential of silage as a method for recovering fish viscera infested with Anisakis.

Pilot-scale process development for recombinant adeno-associated virus (rAAV) production based on high-density Sf9 cell culture

BackgroundIn recent years, gene therapy drugs have been widely marketed, and their effectiveness and potential have been confirmed. Thus, increasing their production on an industrial scale is critical. Recombinant adeno-associated viruses (rAAVs) are optimal vectors for gene therapy applications, and the baculovirus expression vector system (BEVS), which is based on Sf9 cell culture, is a common tool for rAAV production.MethodsIn this work, an Sf9 cell fed-batch process was developed using shake flasks. In the laboratory-scale bioreactor, four processes were selected as the key factors when carrying out the orthogonal experiment. On the basis of the equal P/V principle and considering the problem posed by air bubbles, a pilot-scale level bioreactor process was established.ResultsHere, we describe a method in which a BEVS was used to produce rAAV vectors, with the cell density increasing to 22.8 × 106 cells/mL and the rAAV titre increasing to 20 × 1011 VG/mL upon adding feed material. By resolving the problems associated with high-density cell culture and air bubbles, this process was successfully scaled to a 50 L pilot-scale level.ConclusionsThis successful experiment not only provides a technological basis for further scale-up but also guarantees product capacity. We hope that this development process can provide reference data for studying cell culture-based drug production.

Impact of grinding media shape on the dissociation characteristics and flotation behavior of coking coal middlings

The effective dissociation of feed materials has a major impact on the mineral flotation recovery performance in the mineral processing field. Coking coal middlings is difficult to be effectively dissociated due to its complex internal gangue distribution characteristics. The aim of this paper is to compare and evaluate the performance of ball versus hexagonal prism media for the coking coal middlings comminution by point contact and line-surface contact. The results of the grinding tests show that hexagonal prism could result in a more uniform coal particle size distribution, less over-grinding and better selective dissociation effect comparing with ball. The results of the particle shape coefficient indicate the hexagonal prism milled product has a sphericity (Rs) of 0.90 and an elongation (EW) of 1.69, which is more slender than the ball milled product (Rs = 0.94, EW = 1.47). Flotation tests showed that the hexagonal prism milled product was more hydrophobic with a wrap angle of 185° compared to the ball milled product at 121°. Meanwhile, the TSI value of the hexagonal prism milled product is 80.500, which is lower than the 82.608 TSI value of the ball milled product, indicating that the flotation system of the hexagonal prism mill product is more stable. Under the same flotation test conditions, the combustible matter recovery rate of the hexagonal prism milled product was 5.08 % higher than that of the ball milled product.

DEM simulation of an impact crusher using the fast-cutting breakage model

The impact crusher that exploits impact rather than pressure to break down materials has been widely used in the mineral industry. To further improve its performance in material crushing, numerical simulation capable of providing a deeper insight into the complicated dynamics of feed materials than experimental study has emerged as a promising tool. However, the field of the accurate prediction of product quality and explicit simulation of breakage events inside an industrial-scale crusher remains underexplored on account of the absence of a robust breakage model and heavy computational cost. In this study, a numerical investigation of an industrial-scale crusher using the fast-cutting breakage model is conducted within the DEM (Discrete Element Method) framework. The accuracy of the breakage simulation is quantitatively validated by comparing the predicted results with the measurements from actual production. Furthermore, the influence of operating conditions including the rotation speed of the rotor and the feeding rate on the interested parameters, i.e., the power consumption of the equipment, the size distribution of the products, and the impact-induced wear is investigated comprehensively. The results illustrate that (i) the size of the product increases with the rotor speed until a critical value, after which a further increase in rotor speed will exert no significant influence on the size distribution; (ii) The feeding rate is not a critical operating condition that largely determines the fineness of the product and the efficiency of the equipment almost remain stable under a certain range of feeding rates; (iii) The wear of the devices concentrates on the rotor and the impact plates, and the distribution of the wear exhibits different characteristics in different parts, caused by the complex collision between the particles and the devices.

Dual Function of Sea Grapes (Caulerpa racemosa) As Phytoremediator for Palm Oil Mill Effluent and As Ornamental Fish Feed Formulation.

Phytoremediation is a promising technology for treating Palm Oil Mill Effluent (POME). Moreover, phytoremediators have the potential for various aplication, including as feedstock. Hence, this study aims to elucidate the ability of sea grapes (Caulerpa racemosa) in remediating POME and evaluate their suitability as ornamental fish feed. Results showed that application of sea grapes effectively decreased the COD, TSS, phosphate (PO43-), and nitrate (NO3-) levels in POME. Sea grapes maintained in POME with a concentration of 12.5% had the highest reduction rate and growth performance. Moreover, sea grapes biomass from the remediation process can be utilized as feed material for ornamental fish, as indicated by increasing skin coloration of fish. For the first time, this study provides sustainable options for managing POME using sea grapes and suggests sea grapes as a potential fish feed formulation for ornamental fish.

Effect of Using Germinated and Fermented Lupin and Oats as a Dietary Protein Source on Laying Hen Performance and Egg Quality

Soybean meal is the dominant protein source for poultry nutrition. However, soybean is not widely grown in Europe, necessitating importation from other countries. To reduce dependency on imported soybean meal, an alternative feed material is needed. Fermentation and/or germination of grains are known to increase the value of the protein content of a diet. This study aimed to determine if they could substitute partly soybean meal in a diet. Germinated or fermented or germinated and fermented grains of lupin and oats were used in laying hen’s diet (a mix of 6.50% lupin and 3.50% oat grains). Oats were dehulled or not dehulled. The hens’ weight loss and the downgraded eggs rate were the lowest when using fermented grains. All trial diets reduced the egg cholesterol content. Dehulling had only a slight effect on performance. Diets containing germinated grains led to a decrease in laying performance and an increase in body weight loss. Diets containing fermented grains gave the best results in terms of quantity of amino acids, hen weight maintenance, laying performance, and egg quality. In conclusion, fermented lupin and oats can be used in laying hen diets to partly substitute sources of protein such as soya, but germinated grains cannot.

Comparative plastome analysis of Arundinelleae (Poaceae, Panicoideae), with implications for phylogenetic relationships and plastome evolution

BackgroundArundinelleae is a small tribe within the Poaceae (grass family) possessing a widespread distribution that includes Asia, the Americas, and Africa. Several species of Arundinelleae are used as natural forage, feed, and raw materials for paper. The tribe is taxonomically cumbersome due to a paucity of clear diagnostic morphological characters. There has been scant genetic and genomic research conducted for this group, and as a result the phylogenetic relationships and species boundaries within Arundinelleae are poorly understood.ResultsWe compared and analyzed 11 plastomes of Arundinelleae, of which seven plastomes were newly sequenced. The plastomes range from 139,629 base pairs (bp) (Garnotia tenella) to 140,943 bp (Arundinella barbinodis), with a standard four-part structure. The average GC content was 38.39%, but varied in different regions of the plastome. In all, 110 genes were annotated, comprising 76 protein-coding genes, 30 tRNA genes, and four rRNA genes. Furthermore, 539 simple sequence repeats, 519 long repeats, and 10 hyper-variable regions were identified from the 11 plastomes of Arundinelleae. A phylogenetic reconstruction of Panicoideae based on 98 plastomes demonstrated the monophyly of Arundinella and Garnotia, but the circumscription of Arundinelleae remains unresolved.ConclusionComplete chloroplast genome sequences can improve phylogenetic resolution relative to single marker approaches, particularly within taxonomically challenging groups. All phylogenetic analyses strongly support the monophyly of Arundinella and Garnotia, respectively, but the monophylly of Arundinelleae was not well supported. The intergeneric phylogenetic relationships within Arundinelleae require clarification, indicating that more data is necessary to resolve generic boundaries and evaluate the monophyly of Arundinelleae. A comprehensive taxonomic revision for the tribe is necessary. In addition, the identified hyper-variable regions could function as molecular markers for clarifying phylogenetic relationships and potentially as barcoding markers for species identification in the future.

Research Progress on Mechanization Technology and Equipment for Cassava Field Production

Cassava is one of the world’s staple crops and an important economic and food crop for one billion people. It holds significant value in food, feed, and industrial raw materials. However, cassava production is faced with the following problems: agricultural machinery and agronomy are not integrated, work efficiency is not high, it is not suitable for large-scale planting plots, and there is a lack of large-scale equipment, automation, and intelligent cassava production equipment. This study reviews research on cassava planting agronomy and mechanized production technologies and equipment, including planting, stem–tuber separation, and harvesting, both globally and in China. The shortcomings are analyzed, and recommendations are provided for current mechanized cassava production to accelerate the development of intelligent equipment and strengthen the shortcomings. Meanwhile, we used typical and extensive Chinese planting and harvesting machines as case studies. The future trends in cassava production are forecasted, underscoring the importance of advancing global mechanized technology and equipment for cassava production to enhance its efficiency, competitiveness, and modernization.

Exploitation of Biobased Co-Product Streams; Contributing to European Protein Demands Using Ethanol Plant Derived Co-Products

Abstract Europe is short of high-quality protein for animal feed, being only 29% self-sufficient in high-quality protein and relies heavily on imported proteins. But consumer demand is shifting towards more sustainable, home-grown sources of plant-based protein. This presents a significant challenge for the animal feed industry. Establishing a new plant protein crop for Europe would take a decade to create elite, geographically adapted varieties, adopt new agronomic practices, and establish appropriate supply chains. Approximately 9 million tons of European non-GM grains (maize, wheat, barley and rye) are converted annually by fermentation into bioethanol, a renewable fuel. The residue of the grain is currently used as medium-quality protein animal feed (distillers dried grains and solubles (DDGS; approx. 30% crude protein). Mechanically processing to separate the protein from the fibre fraction produces a Super-Pro (>50%crude protein concentration). The process produces commercially viable quantities of high-quality, non-GM grain protein, that can be used as an alternative to imported soybean products, in a time frame significantly ahead of establishing alternative agronomies or developing alternative novel proteins. Processing technology can transform low-quality co-product steams into high-quality alternative animal feed products and merits further investigation as a means of producing sustainable animal feed. Re-engineering grain bioethanol plants into biorefineries allows them to produce a super high protein (>50% crude protein) feed material concurrently with bioethanol, a renewable fuel. Information © The Authors 2024

Brominated flame retardant in animal feeds from Poland

The safety of food of animal origin is closely related to feed quality. Feed pollution by brominated flame retardants (BFRs) leads to the exposure of animals and consumers of food of animal origin to these substances. The study aimed to assess the concentration of ten PBDE (BDE-28, 47, 49, 99, 100, 138, 153, 154, 183, and 209) congeners and eight nBFRs (TBX, PBT, HBB, PBEB, EH-TBB, BTBPE, BEH-TBPH, and DBDPE) in 59 feed and feed materials from six different feed categories (277/2012/EU). The quantification of analytes was based on isotopic dilution and gas chromatography–high-resolution mass spectrometry (GC-HRMS). All 59 feed samples were contaminated with at least one of the analytes. PBDEs and nBFRs were found in 78% and 91% of the samples, respectively. BFR content ranged from 0.18 to 5.87 μg kg−1 in feed with a 12% moisture content, and the most contaminated category was vegetable oils, followed by fishmeal, feeds for fish, animal fats, and compound feeds for pigs. The least contaminated samples turned out to be compound feeds for chickens. This study confirms the general trend of decreasing PBDE concentrations in fishmeal. In the investigated samples, BDE-47 and BDE-209 contributed the most to the ∑PBDE content. DBDPE, HBB, and PBT contributed the most to the investigated ∑nBFRs. The widespread occurrence of nBFRs in feed seems disturbing because these compounds have replaced PBDEs. Their concentrations in the feed may most likely exceed those of PBDEs in the coming years.

Comparison of nutrient composition and potential feed value of different cakes obtained by cold pressed method

This study aimed to determine nutrient composition and chemical properties of some cakes obtained by cold pressed method proposed as alternative protein sources, and to reveal their usability in animal feeding. The feed materials used in this study are safflower, black cumin (e and m), flaxseed (e and m), carrot seed, walnut, hempseed, and camelina seed cakes. The proximate analysis, metabolic energies, total phenolic content, total flavonoid and antioxidant activity of these cakes were determined and compared. The average percentage nutrients content of the cakes varies from 95.8 (walnut cake) to 91.9 (flaxseed cake e) for dry matter, from 13.1 (carrot seed) to 3.9 (safflower cake) for crude ash, from 23.5 (flaxseed e cake) to 5.5 (hempseed cake) for ether extract, from 46.8 (flaxseed cake m) to 20.0 (safflower cake) for crude protein, from 45.4 (walnut meal) to 21.9 (safflower cake) for nitrogen-free extract, and from 9.4 (flaxseed m) to 2.2 (safflower cake) for sugar. Starch content was below detectable level in all feed samples. The highest crude fiber was at 37.1, NDF at 52.7, and ADF at 40.4 were found in safflower cake. The highest metabolic energies for poultry (12.8 Mcal kg-1) and for ruminants (14.01 Mcal kg-1) were obtained from black cumin seed cake (e). The highest total flavonoid content (3.15 mg GAE/g) and total flavonoid (2.64 mg QE/g) were found in walnut cake. The antioxidant activity (%) varied from 31.3 for black cumin seed cake (m) to 6.7 for camelina seed cake. Considering the high amount of crude protein (>20%) in the investigated cakes, it is concluded that they can be recommended as alternative protein sources for feeding livestock.

Progress and prospects in the molecular basic research on important traits in sorghum

Sorghum (Sorghum bicolor) is a significant crop serving food, energy, feed, and industrial raw materials, featuring extensive growth adaptability and diverse utility values. Despite the achievements in sorghum breeding in the last decades, conventional breeding methods still confront challenges such as lengthy breeding cycles, low efficiency, and complex genetic backgrounds. With the rapid advancement of molecular biology, genetics, and bioinformatics, molecular breeding has carved new pathways for enhancing sorghum yield and quality. This article reviews the molecular basic research progress in the key agronomic and adaptive traits of sorghum, including grain yield, grain quality, flowering time, plant height, tillering, stress resistance, and male sterility, and discusses future research priorities, offering novel insights and approaches for sorghum breeding.

Genome-Wide Identification of COMT Gene Family in Maize and its Function in Response to Light.

Maize is a major crop, feed, and industrial material. Caffeic acid-O-methyltransferase (COMT) is a methylase closely associated with lignin biosynthesis and plant growth and resistance. In this study, we identified the COMT gene (ZmCOMT) family in maize and further analyzed its phylogenetic evolution, subcellular localization, and its function in response to light. Thirty-one ZmCOMT genes were identified in the maize genome, which were distributed across eight chromosomes and mainly clustered on chromosome 4. Most ZmCOMT proteins were predicted to localize in the cytoplasm. Ten different conserved motifs were present in most ZmCOMT proteins, and motif1, motif6, and motif7 were highly conserved and present in all ZmCOMT proteins. The photoresponsivity elements were conserved among all members, and ZmCOMT22 and ZmCOMT10 genes responsive to light. This result suggests a potential function for these two genes in lignin biosynthesis which a previous study had linked to light regulation. Jasmonic acid responsive and abscisic acid cis-acting elements were present in the promoter regions of family members, thus the family may be regulated by hormone signaling pathways of maize. In summary, ZmCOMT genes are ancient, and the highly conserved motifs may be significant in survival and evolution of maize. Furthermore, light may influence lignin biosynthesis and photosynthesis through ZmCOMT genes. This research provided theoretical basis for lignin biosynthesis of maize and the potential value of ZmCOMT22 and ZmCOMT10 genes to enhance plant photosynthesis for facing global warming.

The role of feed spacers in membrane technology: 45 years of research

Feed spacers are crucial for enhancing the performance and efficiency of membrane-based technologies. Researchers have long focused on optimizing feed spacer designs and materials to improve fluid mixing and mass/heat transfer across membranes. However, these improvements often increase pressure drops, raising energy requirements. Therefore, innovative designs are sought to balance enhanced mass/heat transfer with reduced pressure drops and improved antifouling properties. This study analyzes patterns and trends in the feed spacer field using bibliometric methods, data analysis, and machine learning. The analysis includes 457 articles from the Scopus database, collected on March 5, 2024, covering publications from 1978 to 2023 across 45 journals. The analysis revealed that reverse osmosis technology emerges as the most studied membrane process, with 153 articles. Furthermore, experimental research in this field is preferred over theoretical evaluations, and the impact of feed spacers on mass transfer and pressure drops is the most explored topic, with 197 articles addressing one or more of these phenomena. Additionally, 204 articles focused on feed spacers’ role in fouling, scaling, and biofouling, with commercial feed spacers being the most frequently studied. The Journal of Membrane Science leads in publication volume with 152 articles, and Vrouwenvelder J.S. is the top author in 4 out of 6 metrics. Sentiment analysis of abstracts shows that authors generally express positive sentiments (385 articles) while maintaining an objective (453 articles) and emotion-free (446 articles) writing style.

Pelatihan Pembuatan Pakan Ternak Fermentasi Berbahan Baku Sumberdaya Lokal Di Kelompok Tani Ternak (KTT) Berlian Desa Sukadana

The purpose of this activity is training in special production technology for fermented feed using local resources such as straw and others. The implementation of preparation for community service activities includes: initial observation/survey activities, identification of potential and problems, preparing an action program plan, determining activities, coordinating and taking care of permits for all parties related to the service activities. The results obtained were that most group members did not utilize local raw materials for animal feed and they did not provide fermented animal feed for their livestock. Providing an understanding of the importance of the concept of increasing livestock production in the form of information transfer, knowledge about the concept of fermented animal feed related to its benefits and functions for increasing production carried out through FGD and lecture methods. During the discussion session, input and feedback were obtained from participants that could be useful for the implementation of the service process. The next session was a demonstration or practice of making fermented animal feed using local resources. In the follow-up stage, assistance was provided in providing fermented animal feed to each farmer's livestock, with the hope that the livestock would accept and eat the results of the fermented feed so that it could increase production and increase the income of livestock farmers. The implementation of community service activities went according to plan and could be realized according to expectations. In order to optimize and massively implement the activity of making fermented animal feed among livestock farmers, especially in the surrounding areas, the next community service activities were carried out in various community groups that could be directly affected by handling vulnerable animal feed.

Effects of poultry by-product meal and complete replacement of fish oil with alternative oils on growth performance and gut health of rainbow trout (Oncorhynchus mykiss): a FEEDNETICS™ validation study

BackgroundAquaculture, traditionally a form of biotechnology, has evolved to integrate innovative biotechnological applications, such as advanced feed formulations, aimed at improving the growth performance and health of farmed fish species. In the present study, the effects of feeding rainbow trout with novel feed formulations were investigated. Fish growth, gut and liver morphology, the concentration of fatty acids in the fillet, and volatile fatty acids in the gut were assessed. The study also validated scenarios from in vivo experiments using a nutrient-based model called FEEDNETICS™. This globally used model serves as a tool for data interpretation and decision support in the context of precision fish farming.MethodsAlternative protein and oil sources, including poultry by-product meal (PBM) and natural algae oil, were explored as sustainable replacements for fishmeal (FM) and fish oil (FO). A 90-day feeding trial was conducted using rainbow trout, comparing two isoproteic, isolipidic and isoenergetic diets. The control diet contained 15% FM, 5% PBM, and 8% FO, while the test diet replaced FM with 15% PBM and 5% feather meal hydrolysate (FMH), and fully substituted FO with VeraMaris® natural algae oil and rapeseed oil.ResultsPBM successfully replaced FM protein without negatively affecting feed intake, growth performance or feed utilization in trout. The combination of PBM and natural algae oil was well tolerated by the trout and showed no negative effects on gut health. A detailed analysis of fatty acids in the fillet revealed that PUFAs of the n3 and n6 series were significantly higher in the PBM group than in the FM group. Values of fatty acid-related health indexes, including atherogenicity index, and thrombogenicity index, confirmed the high nutritional value of trout filet, thus representing a healthy product for human. In addition, the predictions using the FEEDNETICS™ indicated that the tested novel alternative formulations are economically viable. The validation of the model for fish growth resulted in a Mean Absolute Percentage Error (MAPE) of 8%.ConclusionsThe FEEDNETICS™ application enhances our ability to optimize feeding strategies and improve production efficiency in the aquaculture industry. VeraMaris® algae oil and PBM could serve as viable and sustainable raw materials for fish feed, promoting environmentally friendly aquaculture practices.

Thermo‐rheological snapshot of melter feed conversion to glass

AbstractSlurry feed charged into an electric melter creates a layer of reacting and melting material (termed cold cap) that floats on the surface of molten glass. The rheological behavior of heated melter feed affects the spreading of slurry at the top of the cold cap and the stability of the primary foam, affecting cold‐cap coverage and melter plenum temperatures. The apparent viscosity of a high‐alumina high‐level waste melter feed was assessed by thermomechanical analysis, high‐temperature viscometer, and the hot stage microscopy method, yielding viscosity estimates from ≈107.5 Pa s at 550°C to ≈102.5 Pa s at 1050°C. As the temperature of feed materials increased, their state changed from rigid solid to dilatant fluid, to pseudoplastic bubbly liquid with dissolving solids, to fully developed foam, and finally to Newtonian glass melt.

Sustainable dairy farming and fipronil risk in circular feeds: insights from an Italian case study

Circular feeds, such as grain dry distillers, citrus pulp, cane molasses, and potatoes peels, are co-products of biomass processes. They are currently proposed in animal nutrition to improve the environmental and economic sustainability of the food production chain. In this paper, we report a case study involving fipronil, a pesticide currently not authorized for agriculture within the EU, but used in the Americas, Eastern Europe, and Asia. Fipronil was found at a mean level of 0.49 mg/kg, in a grain dry distiller batch administered to dairy cows. This finding, along with other evidence of potential fipronil presence in feed materials, prompted us to evaluate the risk to food safety and food security from 12 different conventional and sustainable feeding regimens. To this purpose, we considered a fipronil feed-to-milk carry-over rate of 0.52, the tolerance levels in fodders and food from The EU, Codex Alimentarius, and US-EPA, and the Acceptable Daily Intake (ADI) of 0.0002 mg/kg body weight for adverse effects on thyroid function in dairy cows. Under a conservative scenario, fipronil-contaminated potato peels and grain distillers in the feeding regimens may play a pivotal role in exceeding the EU Maximum Residue Level (MRL) in bovine milk and fat (0.005 and 0.030 mg/kg, respectively). Hay-based diets with soybean hulls and cane molasses show negligible risks (Hazard Index ∼ 1). In all cases, the ADI exceedance suggests the need to evaluate thyroid function in dairy cows exposed to fipronil as a food security factor.

Теоретические исследования процесса смешивания кормов центробежным смесителем

The article presents theoretical studies aimed at understanding the physical processes occurring in the production of compound feeds using a centrifugal cascade mixer, which open up new horizons in optimizing feed production technology. Special attention in these studies is paid to the analysis of the mixing process, which, as it turned out, is closely interrelated with the principles of operation of the dispenser. As a result of the analysis, it was found that the dispenser and mixer should be considered as a single system, regardless of the mixing mechanism used in the production process. This made it possible to develop a cascade mixer of feed materials of centrifugal type and continuous action, which is an innovative solution in the field of feed production. This mixer provides a homogeneous mixture of loose feed components and can be integrated into production lines for the preparation of both feed and combined mineral briquettes. The key advantage of the proposed mixer is the use of a centrifugal force field, which, unlike the gravity field, provides more efficient mixing. In this case, the process of preparing compound feeds can be represented as a sequence of three key stages: the metered supply of components, the introduction of one component into the composition of another, transportation (removal) of the finished product from the working area of the mixer. The research allowed us to obtain analytical dependences of the components of the centrifugal force on the angular velocity of the rotor and its radius. This allows you to optimize the operating parameters of the mixer to achieve maximum mixing efficiency. During the research, a mathematical model of the spatial motion of a particle in a mixer was developed. The model is presented in the form of Lagrange equations of the second kind, the generalized coordinates of which are the displacement of the particle along the cone and the polar angle of the particle position. This makes it possible to solve the optimization problems of centrifugal mixers according to a given objective function. Thanks to the conducted research, it was possible to develop an innovative mixer that provides a homogeneous mixture of components of loose compound feeds. The use of centrifugal forces in the mixer made it possible to increase the mixing efficiency and ensure that the final product meets the requirements of the formulation. The research results are of great practical importance and can be used to improve feed production technologies. Keywords: COMPOUND FEED, FEED MIXTURE, MIXER, DISPENSER, CENTRIFUGAL MIXER, PARTICLE MOTION IN THE MIXER