Feasibility Study In Porcine Model Research Articles

Robot-Assisted Nephrectomy Using the Newly Developed EDGE SP1000 Single-Port Robotic Surgical System: A Feasibility Study in Porcine Model.

Objectives: To evaluate the feasibility and safety of the EDGE SP1000 single-port robotic platform by performing nephrectomy in live porcine model. Materials and Methods: Robotic nephrectomy was performed on sample group of five gilts using the EDGE SP1000 single-port robotic system. The continuous vital signs of all gilts were monitored throughout the operation to examine the safety of the operation. Data regarding surgical complications and technical difficulties throughout the operation were recorded for future evaluation. Finally, the survival of the sample gilts 2 weeks after the operation were recorded. Results: The robot-assisted nephrectomy yielded an impressive result that all sample gilts survived after 2 weeks. Furthermore, neither surgical complications nor technical difficulties were encountered during the operation. The average duration to establish the operation channel was 12.4 ± 1.52 minutes, the average time taken to install EDGE SP1000 single-port robotic system was 2.8 ± 0.84 minutes, the average time to dissociate and remove the kidney was 47 ± 5.61 minutes, and average total operational duration was 71 ± 5.24 minutes. Most importantly, the surgeon and assistant who were using the system found it convenient and performed excellently during the operation. Conclusions: This study shows that the EDGE SP1000 single-port robotic surgical system is safe and feasible for the use of nephrectomy in gilts. Our further research will expand the application of the EDGE SP1000 system to other urologic procedures and accumulate more preclinical data for further clinical trial.

Endoscopic ultrasound-guided lymph node ablation with a novel radiofrequency ablation probe: feasibility study in an acute porcine model

Radiofrequency ablation (RFA) is an accepted method of tissue destruction for solid organ tumors. Endoscopic ultrasound (EUS)-guided RFA has been used for lesions in the pancreas and liver, but there is limited experience of lymph node ablation using EUS-guided RFA. The aim of this study was to determine feasibility and safety of prototype EUS-guided RFA of mediastinal lymph nodes. This was an endoscopic experimental feasibility study in a porcine model. After EUS-guided puncture of targeted lymph nodes, the stylet of a 19-G needle was replaced by a prototype RFA probe. RFA was performed by ERBE generator (bipolar settings: 10 watts, effect 2, 2 minutes). The animals were euthanized, and the targeted lymph nodes were identified and removed for histology and measurement of the effect achieved. A total of 18 mediastinal lymph nodes were ablated (mean size 20.8 ± 6.6 mm in the long axis). The average length of exposed probe was 10.0 ± 3.0 mm. The mean length and diameter of necrosis was 9.8 ± 3.6 mm and 5.5 ± 1.6 mm, respectively. Linear regression comparing needle length with necrosis diameter revealed a coefficient gradient of r = 0.92 (P = 0.0001). With EUS-RFA a mean of 17.6 ± 10.3 % (range 8.0 % - 53.2 %) of the respective lymph node area was ablated. No complications (i. e. hemodynamic instability, local bleeding, tissue damage) occurred during the procedure. Technical problems included stripping of the probe by the EUS needle and bending of the tip of the probe. EUS-RFA of lymph nodes was performed safely and successfully using a prototype EUS-compatible probe. This method may have the potential for future use in patient care.

977: Endoluminal Ureteroplasty for Ureteroenteric Stricture - A Feasibility Study in Porcine Model

You have accessJournal of UrologyModerated Poster 29, Monday, May 21, 2007, 1:00 - 3:00 pm1 Apr 2007977: Endoluminal Ureteroplasty for Ureteroenteric Stricture - A Feasibility Study in Porcine Model Victor C. Lin, Allen W. Chiu, Mihir M. Desai, and Inderbir S. Gill Victor C. LinVictor C. Lin More articles by this author , Allen W. ChiuAllen W. Chiu More articles by this author , Mihir M. DesaiMihir M. Desai More articles by this author , and Inderbir S. GillInderbir S. Gill More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)31205-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "977: Endoluminal Ureteroplasty for Ureteroenteric Stricture - A Feasibility Study in Porcine Model." The Journal of Urology, 177(4S), p. 323 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 323 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Victor C. Lin More articles by this author Allen W. Chiu More articles by this author Mihir M. Desai More articles by this author Inderbir S. Gill More articles by this author Expand All Advertisement PDF downloadLoading ...