Introduction: Single incision laparoscopic cholecystectomy (SILC) is a considerable option in benign gallbladder surgery. However, the safety and feasibility of SILC in acute cholecystitis has not been confirmed. We report our surgical outcomes of SILC in acute cholecystitis compared with conventional laparoscopic cholecystectomy (CLC). Methods: 386 patients who underwent SILC and 592 patients who underwent CLC for acute cholecystitis between April 2010 and December 2018 in single institution were retrospectively reviewed the preoperative characteristics and surgical outcomes. Results: The patients in CLC group were older (55.1 vs 65.0 years, p< 0.001), higher ASA score (12.7 vs 35.5% in over III, p< 0.001), and higher incidence of preoperative percutaneous transhepatic gallbladder drainage (PTGBD) than the patients in SILC group. According to Tokyo guideline 18, the patients above grade 2 were more common in the CLC group (15.8 VS 24.3%, p=0.001). There is no statistical significance in operative time, Blood loss, intra-operative transfusion, adjacent organ injury, open conversion, postoperative complication, incisional hernia, and mortality. The length of postoperative hospital stay was significantly shorter in SILC group. On multivariable analysis, grade II or III acute cholecystitis according to Tokyo guideline 18 (TG18), was risk factor for major complication and prolonged operative time. Conclusion: In our experience, SILC can be a safe and feasible treatment for acute cholecystitis, if appropriate experience and when expertise is available. However, in case of grade II or III acute cholecystitis according to TG18, SILC should be selected carefully.
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