Feasibility Of Combined Use Research Articles

Increasing the efficiency of hypolipidemic therapy with the combined use of quercetin in patients with non-alcoholic fatty liver disease on the background of the metabolic syndrome

The article analyzes the results of a set of biochemical indicators in the course of treatment with the combined use of rosuvastatin with quercetin in patients with metabolic syndrome (MS) combined with non-alcoholic fatty liver disease. Changes in blood biochemical parameters have been identified and presented with MS, essential for revealing generalbiological mechanisms development and interrelationship between the components of MS and non-alcoholic fatty liver. The effect of an increase in free cholesterol and triglycerides and activation of freeradical oxidation of lipids followed by theaccumulation of oxidative stress products was noted. In the course of long-term hypolipidemic therapy (90 days), 86 patients with non-alcoholic fatty liver disease on the background of metabolic syndrome were previously divided into 2 groups: a comparison group (45 patients), who weretreated with basic therapy – only rosuvastatin, the main group (41 patients) received quercetin together with rosuvastatin –40 mg 3 times a day, clinical and laboratory-instrumental examinations were carried out. On the 90th day of treatment, positive results in the functional state of the liver and lipid spectrum of the blood wereregistered in all patients. A more significant advantage of the therapeutic combination of rosuvastatin with quercetin was proved. The inclusion of quercetin contributed to reducing the intensity of oxidative stress and enhancing antioxidant protection activity, resultingin a decrease in apoptosis of hepatocytes (cytokeratin-18 level was 1.27 times decreased). The studies have shown the feasibility of combined use of quercetin with rosuvastatin for the prevention of the development and progression of metabolic disorders associated with non-alcoholic fatty liver disease.

Effects of biologically active substances from brown algae on the resistance of erythrocyte membranes

A study of different modes of administration of bioactive substances (BAS) of algae F. vesiculosus and S. latissima to laboratory animals allowed the authors to establish the doses and duration of administration, at which the complexes under study show moderate cytoprotective activity (15 and 30 mg/kg for S. latissima, 60 and 120 mg/kg for F. vesiculosus; three-day administration). It was found that the complex of BAS F. vesiculosus is characterized by a higher activity with respect to erythrocyte osmotic resistance compared to the complex of BAS S. latissima. At the same time, the complex of BAS laminaria is characterized by a higher activity with respect to erythrocyte peroxide resistance. The above features emphasize the feasibility of combined use of these extracts. At three-day combined administration of complexes of BAS F. vesiculosus and S. latissima at doses of 60 and 15 mg/kg, respectively, their high membrane-protective and antioxidant activity was determined. However, a higher dose or longer administration of the BAS complexes negatively affects the resistance of erythrocyte membranes.

Evaluating the feasibility of combined use of the Northern Sea Route and the Suez Canal Route considering ice parameters

Even though the Arctic ice is melting and Polar routes are being extensively studied, the amount of cargo shipped through the Northern Sea Route (NSR) remains low. Employing current data on the NSR operation provided by China Ocean Shipping Company, this paper investigates annual profitability of the NSR-SCR combined use, when a vessel sails through the NSR in summer and the SCR in winter. A Handysize general cargo ship is used as a model vessel since it allows reaching nearly maximum load rate and can sail through shallow areas of the NSR. This article proposes including ice thickness and ice conditions in the traditional cost comparison. The first parameter directly affects sailing speed, and hence other cost variables, while the second one is included in the official NSR navigation rules and connected with icebreaker escort fee. This paper also contributes to the existing literature by considering total shipping cost as a function of a vessel's ice class with corresponding building premiums and fuel consumption increments. The proposed approach is easily replicable, so shipping companies might use it to rethink their positions on shipping through the NSR. The overall conservative comparison reveals that the NSR-SCR combined shipping scheme can only be more competitive than sailing through the SCR if a shipping company provides a sufficient load rate on the NSR leg and uses a ship of a reliable ice class to navigate throughout the summer navigation. The NSR-SCR combined shipping scheme becomes attractive if the NSR leg is short, and the crude oil price is high.

Case of effective endovascular treatment of venous gangrene

Presented in this article is a clinical case report regarding treatment of a patient with deep vein thrombosis complicated by venous gangrene having developed 10 days after the onset of the disease. Conservative therapy (infusion of colloids and crystalloids, anticoagulants, agents improving microcirculation, venotonics, nonsteroidal anti-inflammatory drugs, elevated position of the limb) made it possible to stabilize the patient's condition, but not improving haemodynamics of the affected limb. A decision was made to use endovascular techniques. Treatment was carried out in three stages. The first stage during 48 hours consisted in regional catheter thrombolysis with urokinase, exerting a minimal clinical effect. The second stage was percutaneous mechanical thrombectomy after which the diameter of thrombosed veins became free by half, with the beginning of disease regression. The third stage consisted in venous stenting of residual stenosis of the iliac vein, resulting in normalization of the venous outflow from the affected limb. A conclusion was drawn on feasibility of combined use of regional thrombolysis, percutaneous mechanical thrombectomy, and venous stenting in treatment of venous gangrene.

Evaluation of Delamination in Concrete by IE Testing Using Multi-Channel Elastic Wave Data.

The main objectives of this study are to develop a non-destructive test method for evaluating delamination defects in concrete by the Impact-echo test using multi-channel elastic wave data and to verify the validity of the proposed method by experimental studies in the laboratory. First, prototype equipment using an eight-channel linear sensor array was developed to perform elastic wave measurements on the surface of the concrete. In this study, three concrete slab specimens (1500 mm (width) by 1500 mm (length) by 300 mm (thickness)), with simulated delamination defects of various lateral dimensions and depth, were designed and constructed in the laboratory. Multi-channel elastic wave signals measured on the three concrete specimens were converted to the frequency-phase velocity image by using the phase-shift method. A data processing method was proposed to extract the dominant propagating waves and non-propagating waves from the dispersion images. The dominant wave modes were used to evaluate delamination defects in concrete. It was demonstrated that the surface wave velocity values were useful for characterizing the shallow delamination defects in concrete. In addition, the peak frequency of non-propagating wave modes extracted from the dispersion images gives information on the lateral dimensions and depths of the delamination defects. This study also discussed the feasibility of combined use of the results from propagating and non-propagating wave modes to better understand the information on delamination defects in concrete. As will be discussed, the multi-channel elastic wave measurements enable more accurate, consistent, and rapid measurements and data processing for evaluation of delamination defects in concrete than the single-channel sensing method.

Recent updates and future perspectives about amygdalin as a potential anticancer agent: A review.

The overall incidence of cancer is increasing in recent years. Despite advances in various comprehensive treatments, the mortality of advanced malignant tumors remains at a high level. Numerous pharmacological studies have confirmed that many Chinese herbal medicines possess remarkable antitumor activities. Amygdalin, mainly existing in bitter almond, is reported to have antitumor properties in addition to the antioxidative, antibacterial, anti‐inflammatory and immunoregulatory activities. This article summarizes the structural characteristics of amygdalin, its antitumor mechanisms, and recent progress and achievement in the research of amygdalin, hoping that it could provide theoretical clues for exploring the clinical value of amygdalin against tumors. Amygdalin is known to have an antitumor effect in solid tumors such as lung cancer, bladder cancer and renal cell carcinoma by affecting cell cycle, inducing apoptosis and cytotoxicity, and regulating immune function. Further research is needed to elucidate the pharmacological mechanisms of amygdalin in terms of the optimal dosage, the feasibility of combined use of amygdalin with other antitumor drugs, and even artificial synthesis of the active components in amygdalin, for the sake of enhancing its antitumor activities and reducing its adverse effects for clinical use.

Combined Endoscopic and Microscopic Posterior Transseptal Transsphenoidal Pituitary Surgery with Neuronavigation

The aim of this presentation to establish the feasibility of combined use of endoscope and microscope for transsphenoidal sella surgery, to demonstrate the role of neuronavigation in operations and reoperations of TSS. Technical advancements such as development of navigation system have revolutionized the field of endoscopic endonasal surgery. Endoscopic and microscopic techniques are presented in the literature as alternative and competitive approaches. The authors think they are complementary and that the use of both will make surgical technique better. Prospective monocentric study. 209 patients with sellar lesions were operated in our department in the past 5 years. 36 patients with pituitary tumor were operated with the aid of an optically guided system. Total resection was achieved in all patients. Frameless stereotaxy system is accurate and obviates the need for intraoperative fluoroscopy during transsphenoidal surgery. It is useful in microadenomas, complex cases, redo cases, where the anatomical landmarks are not easy to recognizable. It makes the selected procedures easier, faster and probably safer.

Application of EFDC and WASP7 in Series for Water Quality Modeling of the Yongdam Lake, Korea

This study aims to test the feasibility of combined use of EFDC (Environmental Fluid Dynamics Code) hydrodynamic model and WASP7.3 (Water Quality Analysis Program) model to improve accuracy of water quality predictions of the Yongdam Lake, Korea. The orthogonal curvilinear grid system was used for EFDC model to represent riverine shape of the study area. Relationship between volume, surface and elevation results were checked to verify if the grid system represents morphology of the lake properly. Monthly average boundary water quality conditions were estimated using the monthly monitored water quality data from Korean Ministry of Environment DB system. Monthly tributary flow rates were back-routed using dam discharge data and allocated in proportion to each basin area as direct measurements were not available. The optimum number of grid system was determined to be 372 horizontal cells and 10 vertical layers of the site for 1 year simulation of hydrodynamics and water quality out of iterative trials. Monthly observed BOD, TN, TP and Chl-a concentrations inside the lake were used for calibration of WASP7.3 model. This study shows that EFDC and WASP can be used in series successfully to improve accuracy in water quality modeling. However, it was observed that the amount of data to develop inflow water quality and flow rate boundary conditions and water quality data inside lake for calibration were not enough for accurate modeling. It is suggested that object-oriented data collection systems would be necessary to ensure accuracy of EFDC-WASP model application and thus for efficient lake water quality management strategy development.

SU‐FF‐J‐70: An Investigation of Interference Between Electromagnetic Transponders and Wireless MOSFET Dosimeters

Purpose: A phantom study to systematically investigate potential interferences between Calypso® Medical electromagnetic transponder and Sicel® DVS wireless MOSFET dosimeter when used in same patient. Method and Materials: A 30×30×5cm3 (Virtual Water®) phantom has a center hole for two separate 8cm diameter inserts with grooves for three pairs of transponders and dosimeters on each insert, respectively. The grooves of orthogonal and parallel orientations between transponders and dosimeters (long axes) were machined on the two inserts, respectively, with transponder‐dosimeter distance at 0, 1 and 2cm. In the transponder‐localization test (test1), transponder locations were obtained without and with dosimeters at different distances. Multivariate analysis tested the null hypothesis: the localized transponder coordinates are the same among datasets of control and various dosimeter locations. The 95% confidence‐intervals were also determined for the localization difference between control and test groups. In the dose‐measurement test (test2), 7 fractions of 1Gy were administrated to the dosimeters inside the phantom in an alternating fashion of without (fraction♯ 1, 3, 5, 7) and with transponders. Readings from fractions of no transponders were fit using a 2nd order polynomial. The dose differences between fit‐interpolated and corresponding measured values of fraction 2, 4, 6 were calculated. Results: For test1, multivariate analysis indicated that transponder localization accuracy was affected by the dosimeter. However, the 95% confidence‐intervals of the localized positional differences between control and test groups were less than 0.1mm, which is less than Calypso clinical display increment, 0.5mm. For test2, the maximum deviation of polynomial fitted dose values from measurements are within 1.5% and 0.8% for orthogonal and parallel configurations, respectively. Conclusion: This study showed no clinically significant interference between the transponder and dosimeter systems and demonstrated feasibility of combined use of transponders and dosimeters in the same patient.Research sponsored by Calypso Medical Technologies, Inc. and Sicel Technologies, Inc.

Feasibility of combined use of intravascular ultrasound radiofrequency data analysis and optical coherence tomography for detecting thin-cap fibroatheroma

To evaluate the feasibility of the combined use of virtual histology (VH)-intravascular ultrasound (IVUS) and optical coherence tomography (OCT) for detecting in vivo thin-cap fibroatheroma (TCFA). In 56 patients with angina, 126 plaques identified by IVUS findings were analysed using both VH-IVUS and OCT. IVUS-derived TCFA was defined as an abundant necrotic core (>10% of the cross-sectional area) in contact with the lumen (NCCL) and %plaque-volume >40%. OCT-derived TCFA was defined as a fibrous cap thickness of <65 microm overlying a low-intensity area with an unclear border. Plaque meeting both TCFA criteria was defined as definite-TCFA. Sixty-one plaques were diagnosed as IVUS-derived TCFA and 36 plaques as OCT-derived TCFA. Twenty-eight plaques were diagnosed as definite-TCFA; the remaining 33 IVUS-derived TCFA had a non-thin-cap and eight OCT-derived TCFA had a non-NCCL (in discord with NCCL visualized by VH-IVUS, mainly due to misreading caused by dense calcium). Based on IVUS findings, definite-TCFA showed a larger plaque and vessel volume, %plaque-volume, higher vessel remodelling index, and greater angle occupied by the NCCL in the lumen circumference than non-thin-cap IVUS-derived TCFA. Conclusion Neither modality alone is sufficient for detecting TCFA. The combined use of OCT and VH-IVUS might be a feasible approach for evaluating TCFA.

In vitro and in vivo Effects of Cisplatin and Etoposide in Combination on Small Cell Lung Cancer Cell Lines

The effects of cisplatin (CDDP) and etoposide (ETP) in combination were evaluated in vitro and in vivo using small cell lung cancer cell lines. The combination effects in vitro were investigated using isohologram analysis. Used together, CDDF and ETP showed a synergistic effect against cell growth on only 1 cell line (SBC‐3), additive effects on 6 (SBC‐2, SBC‐5, Lul30, Lul34AH, Lul35T and H69) and an antagonistic effect on 1 (SBC‐1). In the in vivo experiment, nude mice were inoculated with SBC‐1, SBC‐3 and SBC‐5 cells. Two or 5 mgAg CDDP and 10 or 30 mgAg ETP were administered intraperitoneally alone and simultaneously in combination to nude mice. The in vivo effects of the combination were determined by comparing the observed growth ratio in mice treated with the combination with the expected value of this ratio calculated based on the assumption that the effects of the drugs were simply additive. According to this definition, synergistic effects were observed against all 3 tumors. Thus, the in vivo and in vitro effects differed. The toxicity of the combination therapy, which was analyzed by estimating the body weight change of mice, was no higher than that of CDDP or ETP alone. These results suggest that the excellent clinical effects of CDDP and ETP combination therapy may he attributable not to drug interaction at the cellular level hut to the feasibility of combined use of them at full doses without overlapping side effects.