Carrier aggregation transmissions in frequency division duplexing devices reduce the duplexing distance between the transmitter (TX) and receiver (RX) bands. As a consequence, the spurious intermodulation distortion products created by the nonlinear RF front-end of the TX may easily extend over to the RX band, potentially causing own RX desensitization. In this paper, we propose an efficient and computationally feasible adaptive digital identification and cancellation technique to mitigate the RX desensitization. We first show that the spurious leakage signal at own RX band depends on an equivalent leakage channel that models the overall signal leakage path including the TX nonlinearities, duplexer filter responses, and RX path. The parameters of the equivalent leakage channel can be efficiently estimated with the least squares or the recursive least squares algorithm, using the actual digital transmit data as a reference, and then used to regenerate and cancel the leakage interference from the received signal. The performance of the proposed technique is evaluated with extensive computer simulations, as well as with practical real-world RF measurements, demonstrating excellent calibration properties with up to 19-dB improvement in singal-to-interference plus noise ratio of the desired received signal.