The monitoring of complex industrial systems through the implementation of smart approaches provides unique opportunities, such as the characterisation of their real-time performance. Within this scope, there exists the need to support decision-making during maintenance processes, due to the presence of a multitude of faults in real-world systems and the difficulty of identifying the appropriate mitigating solutions. The proposed solution uses intelligent optimisation techniques to identify the ideal control solution within these complex systems when faults arise. This paper presents a framework based on an intelligent optimisation approach, which provides a workflow process for the support of decision-making during faulty situations. It is adapted and implemented to the demand-side of a Compressed Air System (CAS), thus providing a holistic approach in automating fault mitigation during real-time system operation. In implementing this framework, multiple intelligent optimisation techniques such as the Genetic Algorithm and the Particle Swarm Optimisation algorithms were adopted and implemented. Both algorithms were successful in providing the ideal control solution under fault conditions. For a typical production case study, the proposed optimisation approach results in a reduction of 40% in its air consumption, which directly improves its environmental performance and energy costs. This result demonstrates that this approach contributes a suitable control strategy for CAS when experiencing a pneumatic fault, which has a direct positive effect on the operational energy performance and costs.