Fatigue damage is a main concern during the life-cycle maintenance of bridges with corroded hangers under vehicle-bridge interaction (VBI). In this study, a novel noniterative simplified method for VBI is proposed to analyze the responses of hangers in a network arch bridge, considering the effects of vehicle types, driving lanes, and road surface roughness. Furthermore, the fatigue life of corroded hangers is investigated, considering the actual traffic flow and uneven distribution of stress in the hanger’s cross-section. The results show that longitudinal and transverse bending moments of the hanger significantly affect the stress of steel wires in one hanger but have limited influence on stress amplitudes. The fatigue lives of steel wires are considerably reduced when subjected to both uniform and pitting corrosion. The fatigue life of steel wires is reduced under deteriorating road surface conditions. Moreover, as the fatigue life of steel wires in the hangers declines, the variations in fatigue life among individual steel wires within a single hanger gradually decrease. Consequently, this trend leads to a heightened likelihood of continuous wire breakage.
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