Riveting is the most important method of joining sheet metal and is widely used in the assembly of aircraft components. The perpendicularity error of the holes is unavoidable during automatic drilling and riveting, which has a significant impact on the quality of the assembly. In this paper, the effects of hole perpendicularity error and squeeze force on the interference fit size, interface contact state, microstructure morphology, fatigue life, and fracture form of riveted joints were investigated experimentally. The results show that the interference fit size increases with a greater tilt angle. When the tilt angle is 0°, the rivet shank is in close contact with the inner and outer sheets, and there is no obvious gap at the interface between the rivet and the sheets. As the tilt angle increases to 2° and 4°, a gap appears at the interface of regions 1, 2, and 3, while the rivet shank at region 4 is in close contact with the outer sheet. The fatigue life decreases when the tilt angle increases from 0° to 4°. For the same tilt angle, the fatigue life of riveted joints with a 0° tilt direction is higher than that of riveted joints with a 180° tilt direction. Increasing the squeeze force can to some extent reduce the adverse effect of the tilt angle on the fatigue life. The hole perpendicularity error does not affect the failure form, while the squeeze force has a significant effect on the failure form of the specimens. RESEARCH HIGHLIGHTS: The fatigue life of riveted joints decreases as the tilt angle increases. The size of the interfacial gap increases with increasing tilt angle. Higher fatigue life at 0° tilt direction than at 180° tilt direction. Increasing the squeeze force can somewhat reduce the negative effect of tilt angle on fatigue life.