Fat-rich Foods Research Articles

Strategic approach for converting fat-rich food waste into high-quality biodiesel using black soldier fly larvae for sustainable bioenergy

Food waste (FW) comprises carbohydrates, proteins, lipids, and water, posing technical challenges for effective treatment and valorisation. This study addresses these challenges by using black soldier fly larvae (BSFL) as a bioconversion medium to transform FW into biodiesel (BD). BSFL predominantly consumed the carbohydrates and proteins in FW (81 wt%), while showing a lower preference for lipids (<50 wt% consumed). Notwithstanding the lower consumption of lipids in the FW than that of carbohydrates and proteins, BSFL had a high lipid content (48.3 wt%). The subsequent conversion of the lipids extracted from BSFL into BD was tested via catalytic (acid/alkali) and non-catalytic transesterification processes. The BD yield from catalytic transesterification was lower than that from non-catalytic transesterification because of the low tolerance against free fatty acids (FFAs). BD was also produced from the lipid-concentrated residual FW through non-catalytic transesterification. Although the FW residue extracts contained high amounts of FFAs (49.9 wt%), non-catalytic transesterification displayed a high BD yield (92.4 wt%; yields from catalytic transesterification: < 80.0 wt%). Moreover, blending the BD derived from the BSFL and FW residue extracts enhanced the fuel properties. The BSFL-assisted FW management efficiently reduced FW by 90 wt% while producing a high-quality BD.

The therapeutic landscape of citrin deficiency.

Citrin deficiency (CD) is a recessive, liver disease caused by sequence variants in the SLC25A13 gene encoding a mitochondrial aspartate-glutamate transporter. CD manifests as different age-dependent phenotypes and affects crucial hepatic metabolic pathways including malate-aspartate-shuttle, glycolysis, gluconeogenesis, de novo lipogenesis and the tricarboxylic acid and urea cycles. Although the exact pathophysiology of CD remains unclear, impaired use of glucose and fatty acids as energy sources due to NADH shuttle defects and PPARα downregulation, respectively, indicates evident energy deficit in CD hepatocytes. The present review summarizes current trends on available and potential treatments for CD. Baseline recommendation for CD patients is dietary management, often already present as a self-selected food preference, that includes protein and fat-rich food, and avoidance of excess carbohydrates. At present, liver transplantation remains the sole curative option for severe CD cases. Our extensive literature review indicated medium-chain triglycerides (MCT) as the most widely used CD treatment in all age groups. MCT can effectively improve symptoms across disease phenotypes by rapidly supplying energy to the liver, restoring redox balance and inducing lipogenesis. In contrast, sodium pyruvate restored glycolysis and displayed initial preclinical promise, with however limited efficacy in adult CD patients. Ursodeoxycholic acid, nitrogen scavengers and L-arginine treatments effectively address specific pathophysiological aspects such as cholestasis and hyperammonemia and are commonly administered in combination with other drugs. Finally, future possibilities including restoring redox balance, amino acid supplementation, enhancing bioenergetics, improving ureagenesis and mRNA/DNA-based gene therapy are also discussed.

Improving oxidative stability of cream powder using pomegranate concentrate and peel extract.

In this study, the influence of pomegranate peel extract (PPE) and pomegranate concentrate (PC) on improving the oxidative stability of cream powder in comparison with synthetic antioxidant (Butylated hydroxytoluene (BHT)) during the storage period at 20°C (8 weeks) and 45°C (4 weeks) was evaluated. The finding exhibited that peroxide, p-anisidine, and total oxidation (TOTOX) values increased during the storage period. Samples containing PPE and PC showed suitable performance in controlling the cream powder oxidation. Also, PPE showed the highest antioxidant activity and can be proposed as a suitable replacement for a synthetic antioxidant (BHT). L* and b* values increased, while a* value decreased during the storage period. Also, the pH of the powders decreased significantly throughout the storage (reached nearly 6). Microbial counts of cream powders did not change during the storage period. The control sample showed the highest overall acceptability. Antioxidants of pomegranate can be proposed to control the oxidative stability of fat-rich food products.

A Diet Containing Animal Source Protein as Fresh, Lean Beef Is More Well Liked and Promotes Healthier Eating Behavior Compared with Plant-Based Alternatives in Women with Overweight

BackgroundDespite limited evidence from intervention trials, replacing animal-source protein-rich foods with plant alternatives continues to be recommended as part of a healthy dietary pattern. ObjectivesThe objective of this study was to examine whether a diet containing fresh, lean beef elicits greater satiety, reduces ad libitum food intake, and is more acceptable compared with a diet containing plant alternatives in women with overweight. MethodsSeventeen women with overweight (mean ± SEM, age: 33 ± 1 y; BMI: 27.8 ± 0.1 kg/m2) completed an acute, tightly controlled, crossover design study. Participants were provided with eucaloric, isonitrogenous diets (15% of daily intake as protein) containing either 2 servings/d of fresh lean beef (BEEF) or plant equivalents (PLANT) for 7 d/pattern. During day 6 of each pattern, the participants completed a 10-h controlled-feeding, clinical testing day, which included repeated appetite and satiety questionnaires and blood sampling to assess pre- and postprandial plasma peptide YY (PYY) and GLP-1 across the day. On day 7, the participants completed a free-living testing day in which they consumed their respective protein foods and were provided with additional carbohydrate- and fat-rich foods to consume, ad libitum, during each eating occasion. Energy and macronutrient composition were assessed. A 2- to 3-wk washout period occurred between patterns. ResultsNo differences in daily satiety were detected between patterns. During the ad libitum testing day, 24-h food intake was not different between patterns (BEEF: 2714 ± 219 compared with PLANT: 2859 ± 147 kcals/d), BEEF led to fewer carbohydrates consumed compared with PLANT (338 ± 34 compared with 370 ± 22 g/d, P < 0.05), especially as sugar (169 ± 73 g compared with 186 ± 57 g, P = 0.05). Furthermore, BEEF was more well liked (i.e., higher flavor, texture, and acceptability) compared with PLANT (all, P < 0.05). ConclusionsAlthough satiety was similar between patterns, the consumption of animal-source protein-rich foods, such as fresh and lean beef, was more well liked and resulted in voluntary reductions in total carbohydrate and sugar intake in middle-aged women with overweight during a single ad libitum testing day.This study was registered at clinicaltrials.gov as NCT02614729.

A Snapshot of Glycemic Response to Food Using a Continuous Glucose Monitor

Understanding how specific foods affect one’s blood glucose levels can help diabetic patients make better meal choices. A 35-year-old male diabetic patient was monitored for 6 months using a continuous glucose monitor (CGM). The obtained glycemic response curves for various types of food were analyzed. Meal composition played a crucial role in determining the glucose spike. Foods with high carbohydrate content increased sugars much higher than foods with balanced macronutrients. Combining protein and fat-rich foods with high-carbohydrate foods lowered the sugar spikes caused by a pure carbohydrate meal. Fruits, due to their high fiber and water content, although loaded with carbohydrates, did not spike the sugars much. Commercially available diabetic nutrition powders also had a good glycemic profile. Thus, CGM plays a crucial role in improving the health outcomes of people with diabetes by allowing them to choose the right quantity and quality of food to eat.

Value Addition of Defatted Groundnut Cake

Objective of this study was to prepare defatted groundnut cake flour &amp; develop value added products from it. Groundnut cake flour blends easily and enhances or enriches the nutritive value of products prepared from it. Value added products like laddoo and chutney were prepared from defatted groundnut cake flour. Laddoos were prepared by blending defatted groundnut cake flour with coconut powder in the proportion 55:45 as well as chutney was prepared by mixing defatted groundnut cake flour with roasted chana dal in the proportion 55:45. Nutritional quality parameters namely moisture, protein, fat, carbohydrate, total minerals, crude fiber and energy of defatted groundnut cake flour and its value added products were determined. This study proved that these products can be substitute fat rich and adulterated low quality food products which are often being marketed and consumed. Keywords: groundnut cake, defatted flour, value added products, nutritional quality

Bacterial proteome adaptation during fermentation in dairy environments

The enzymatic repertoire of starter cultures belonging to the Lactococcus genus determines various important characteristics of fermented dairy products but might change in response to the substantial environmental changes in the manufacturing process. Assessing bacterial proteome adaptation in dairy and other food environments is challenging due to the high matrix-protein concentration and is even further complicated in particularly cheese by the high fat concentrations, the semi-solid state of that matrix, and the non-growing state of the bacteria. Here, we present bacterial harvesting and processing procedures that enable reproducible, high-resolution proteome determination in lactococcal cultures harvested from laboratory media, milk, and miniature Gouda cheese. Comparative proteome analysis of Lactococcus cremoris NCDO712 grown in laboratory medium and milk revealed proteome adaptations that predominantly reflect the differential (micro-)nutrient availability in these two environments. Additionally, the drastic environmental changes during cheese manufacturing only elicited subtle changes in the L. cremoris NCDO712 proteome, including modified expression levels of enzymes involved in flavour formation. The technical advances we describe offer novel opportunities to evaluate bacterial proteomes in relation to their performance in complex, protein- and/or fat-rich food matrices and highlight the potential of steering starter culture performance by preculture condition adjustments.

Recent advances in molecularly imprinted polymers (MIPs) for visual recognition and inhibition of α-dicarbonyl compound-mediated Maillard reaction products

α-Dicarbonyl compounds (α-DCs) are important intermediates and precursors of harmful Maillard reaction products (e.g., acrylamide and late glycosylation end-products), and they exist widely in thermoprocessed sugar- or fat-rich foods. α-DCs and their end-products are prone to accumulation in the human body and lead to the development of various chronic diseases. Therefore, detection of α-DCs and their associated hazards in food samples is crucial. This paper reviews the preparation of molecularly imprinted polymers (MIPs) enabling visual intelligent responses and the strategies for recognition and capture of α-DCs and their associated hazards, and provides a comprehensive summary of the development of visual MIPs, including integration strategies and applications with real food samples. The visual signal responses as well as the mechanisms for hazard recognition and capture are highlighted. Current challenges and prospects for visual MIPs with advanced applications in food, agricultural and environmental samples are also discussed. This review will open new horizons regarding visual MIPs for recognition and inhibition of hazards in food safety.

Foods and beverages associated with smoking craving in heated tobacco product and cigarette smokers: A cross-sectional study.

Certain foods and beverages are associated with smoking craving. However, only few studies have explored the relationship between food or beverage-related and taste-associated smoking craving. In this study, we aimed to identify the types of foods related to smoking craving in Japanese individuals who smoke cigarettes or heated tobacco products (HTPs). A total of 657 individuals (HTP and cigarette smokers and never smokers) participated in this cross-sectional study. Participants were asked what foods/beverages, tastes, seasonings, cooking methods, and cuisine categories, made them want to smoke and what foods they consumed. Alcoholic beverages such as beer, coffee, and fat-rich foods were associated with a higher likelihood of smoking craving. Fruits, dairy products such as milk, and sweet and sour tastes, were associated with a lower likelihood of smoking craving. The daily intake of fruit and dairy products was significantly lower in cigarette and HTP smokers than in non-smokers (median fruit intake: non-smokers, 46.4 g/1000 kcal/day; cigarette smokers, 22.2 g/1000 kcal/day; HTP smokers, 31.4 g/1000 kcal/day; p<0.001; median dairy product intake: non-smokers, 76.3 g/day; cigarette smokers, 48.2 g/day; HTP smokers, 57.6 g/day; p<0.001) as assessed using a food frequency questionnaire (BDHQ). Specific foods and beverages such as alcohol, fruits, and dairy products are related to smoking craving, and their intake differs according to smoking status.

Acne Vulgaris in Saudi Arabia – Myths and Common Misconceptions: A Cross-sectional Study

Background: Acne vulgaris is a long-term condition of the sebaceous glands that usually occurs during puberty. The mean prevalence of acne in Saudi males is 54% and ranges from 54% to 84% among Saudi females. Despite the high prevalence of acne vulgaris, it is shrouded in multiple misconceptions that are widely spread among the general public and among patients with acne. Purpose: This study is conducted to assess the knowledge, awareness, and widespread myths and misconceptions about acne vulgaris. Methods: A cross-sectional quantitative study was conducted in Saudi Arabia in August 2022 through 1164 self-administered, convenient sampling technique online questionnaires. Sociodemographic data, as well as knowledge regarding acne and its treatment, were collected and evaluated. Results: Three-quarters of the respondents (73%) knew that stress precipitated acne, and two-thirds (66%) knew that fat-rich food could increase the risk of developing acne. Knowledge was lower in males than females, while a family history of acne was associated with higher knowledge. Most respondents (76%) knew that hormonal changes could precipitate acne. More than half of the respondents did not know whether Vitamin A derivatives increased the risk of depression (61%), anxiety, and stress (55%). Three-quarters of the respondents (73%) knew that stress precipitated acne, and two-thirds (66%) knew that fat-rich food could increase the risk of developing acne. The most common source of information was the Internet (40.8%) followed by social media platforms (25.2%) and physicians (15.2%). Conclusion: There was an adequate level of knowledge. Approximately half of the respondents declared the Internet as a source of their information. We recommend physicians to educate their patients about acne, to elaborate society-oriented campaigns, and to encourage dermatologists to spread information through the Internet and social media platforms as they are considered a major source of information in this study.

PENGARUH TERAPI MUROTTAL SURAH AR-RAHMAN IRAMA JIHARKAH TERHADAP TEKANAN DARAH PENDERITA HIPERTENSI DI UPT GADING REJO

The prevalence of hypertension sufferers in the world and Indonesia is increasing. Various factors related to genetics and lifestyle such as lack of physical activity, intake of salty and fat-rich foods as well as smoking and drinking habits play a role in soaring hypertension rates. One of the complementary therapies that can control blood pressure is murottal surah Ar-Rahman therapy. The aim of the research was to determine the effect of murottal therapy of surah Ar-Rahman with the jiharkah rhythm on changes in blood pressure in hypertension sufferers in the working area of ??the UPT Puskesmas Gading Rejo Pringsewu Lampung. Quantitative research design with a quasi-experimental method with a one group pretest and posttest design without a control group. The research population was hypertension sufferers at the UPT Puskesmas Gading Rejo in September 2023. The total sample was 70 respondents using the purposive sampling method. Analysis used a paired test on systolic blood pressure and the Wilcoxon test on diastolic blood pressure. The results of statistical tests using the paired t test showed that the p-value of systolic blood pressure before and after murottal therapy of surah Ar-Rahman was 0,002 and the results of the Wilcoxon test of diastolic blood pressure before and after murottal therapy of surah Ar-Rahman obtained a p-value is 0,000. In conclusion, there is an effect of murottal therapy of surah Ar-Rahman with jiharkah rhythm on blood pressure before and after intervention is given to hypertension sufferers, so that murottal therapy of surah Ar-Rahman with jiharkah rhythm is effective for lowering blood pressure in hypertension sufferers.

Substitution analyses of foods with varying fat quality and the associations with all-cause mortality and impact of the FADS-1 genotype in elderly men

PurposeTo investigate associations between substitutions of foods varying in fat quality and all-cause mortality in elderly Swedish men and to examine effect measure modification by a gene involved in fatty acid desaturation (rs174550 FADS1). MethodsUsing Cox-regression models in the ULSAM cohort (n = 1133 men aged 71), we aimed to investigate; (1) Associations between the substitution of a nutrient or food for another on all-cause mortality (primary outcome) and CVD (secondary outcome) and (2) Associations between the addition of various fat-rich foods to the habitual diet and all-cause mortality and CVD. Subgroup analyses based on the rs174550 FADS1 genotype were conducted.ResultsOver a mean follow-up of 11.6–13.7 years, n = 774 died and n = 494 developed CVD, respectively. No clear associations were observed for the vast majority of substitution nor addition models. Adding saturated fatty acids (SFA) on top of the habitual diet was however associated with an increased risk of mortality in men with the CT/CC-genotype [HR (95% CI) 1.44 (1.05, 1.97)]. Post-hoc analyses showed an inverse association of substituting SFA with carbohydrates [HR (95% CI) 0.79 (0.65, 0.97)], which was somewhat stronger in men with the CT/CC-genotype compared to men carrying the TT-genotype.ConclusionsFew associations were observed between diet and all-cause mortality and CVD in this population. However, substituting SFA with carbohydrates was associated with lower mortality in post-hoc analyses and adding SFA to the habitual diet increased mortality in men with the CT/CC-genotype. The latter observation is novel and warrants further investigation in larger cohort studies including women.

Development of a glue- and heat- sealable acorn kernel meal/κ-carrageenan composite film with high-haze and UV-shield for packaging grease

Starch and protein-derived films can be used as alternatives to plastics; however, the utilization of starch and proteins to this way might exacerbate the global food shortage. In this study, we used discarded acorns to prepare a glue- and heat-sealable packaging film. We evaluated the mechanical characteristics, thermal stability, transmittance, haze, and antibacterial properties of an acorn kernel meal/κ-carrageenan (AKM/κC) composite film. The results showed that the haze and transmittance decreased from 96.74% to 94.50% and from 3.50% to 2.25%, respectively, when glycerol increased from 30% to 50%. The AKM/κC film had excellent UV shielding properties (transmittance at 380–200 nm was 0). The 45 g-AKM/κC film had a maximum sealing strength of 5.09 ± 0.29 N/15 mm at 0.3 MPa for 1 s (115 °C). Beef tallow packaged in 45 g-AKM/κC exhibited an increased POV from 0.0187 to 0.0336 g/100 g after 75 days, which was lower than that in air (0.5209 g/100 g). Our developed film had high haze and UV shielding performance and can be used as a plastic packaging substitute for fat-rich foods.

Impact of diet on attention-deficit hyperactivity disorder in a tertiary care hospital of Rawalpindi

Background: Attention-deficit hyperactivity disorder (ADHD) is a prevalent neuropsychiatric disorder of children that affects almost all aspects of the life. The role of diet in the management of the ADHD is understudied in Pakistan. This study aimed to assess the impact of different types of diet on the symptoms of ADHD among the children with ADHD. Methods: This descriptive cross-sectional study was conducted among 58 children with ADHD in Rawalpindi. Ethical approval and informed consent were obtained. Patients’ recruitment was done via developed criteria and Convenient sampling technique. Descriptive statistics and one-way ANOVA were used to determine the difference of ADHD severity among various frequencies of different included foods via Conner Parent rating scale-revised short form. Data analysis was performed by SPSS version 25.0. Results: The difference in hyperactivity index, impulsivity, and learning problems score on CPR-RS among various frequencies of carbohydrate, protein rich and fat foods, was statistically significant and with the increase intake of carbohydrate and protein rich foods, the score on CPR-RS of hyperactivity index, impulsivity, and learning problems also goes up. Whereas, with the increase intake of fat rich foods, the score of hyperactivity index, impulsivity, and learning problems goes down. Conclusions: In short, the high intake of carbohydrate and protein rich foods, increase the severity of the symptoms of ADHD, while, high intake of fat rich foods decreases the severity of the symptoms of ADHD among children.

Azelaic acid induces cholecystokinin secretion and reduces fat-rich food preference via activation of Olfr544

Olfactory receptor 544 (Olfr544) is expressed in extra-nasal tissues and has been shown to reduce adiposity and shift fuel preference to fats. Here, we investigated whether Olfr544 regulates feeding behavior. Azelaic acid increased cholecystokinin (CCK) secretion ex vivo and in vivo by Olfr544 dependently. In a two-food choice study, oral administration of azelaic acid reduced high fat diet (HFD) intake and increased normal diet (ND) intake, which was abolished in Olfr544-knockout mice. In a two-bottle preference test, the oral administration of azelaic acid reduced the intake of linoleic acid solution while increasing the intake of control solution (xanthan gum) and the effect of azelaic acid disappeared in Olfr544-knockout mice. Intraperitoneal injection of proglumide, a CCK-1/2 receptor antagonist, negated the effect of azelaic acid in reducing fat preference. Collectively, our findings suggested that Olfr544 activation by azelaic acid reduced calorie-rich high-fat food intake mediated, at least in part, by CCK secretion.

Prevalence of Mental Health Problems Among University Students and Association With Body Mass Index (BMI) and Diet Quality

Introduction: Numerous factors contributed to the susceptibility of university students to develop mental health issues. Objective: This study aimed to assess the prevalence of mental health problems among International Islamic University Malaysia (IIUM) students and their relationships with diet quality and body mass index (BMI). Methods: A cross-sectional study was conducted among 104 students. The Depression, Anxiety, and Stress Scale (DASS-21) was used to assess students’ depression, anxiety, and stress levels. The Malaysian Healthy Eating Index (M-HEI) was used to assess diet quality. Spearman Rho was used to determine the relationships between variables. Results: Approximately 69.4% (n = 34), 71.4% (n = 35), and 48.9% (n = 34) of male students experienced moderate to extremely severe symptoms of depression, anxiety, and stress, respectively. In contrast, 85.4% (n = 47), 89.1% (n = 49), and 54.6% (n = 30) of female students had moderate to extremely severe symptoms of depression, anxiety, and stress, respectively. No correlations were found between diet quality and BMI with students’ mental health problems. For male students, there were negative significant associations reported between fat-rich foods (r = -0.447, p-value = 0.001) and sugar-rich foods (r = -0.332, p-value = 0.020) intake with depression; a positive significant relationship between fruit intake and anxiety (r = 0.284, p-value = 0.048); a positive relationship between fruit intake and stress (r = 0.300, p-value = 0.036); and a negative relationship between fat-rich foods and stress (r = -0.293, p-value = 0.041). Female students only had a significant negative correlation between fish intake and anxiety (r = -0.376, p-value = 0.005). Conclusion: No associations were found between diet quality, BMI, and mental health problems. A more profound comprehension of the connections between risk factors and mental health could lead to new intervention strategies.

Improving microbial and lipid oxidative stability of cheddar cheese using cricket protein hydrolysates pre-treated with microwave and ultrasonication

The study was carried out to investigate cricket protein hydrolysates’ (CPH) potential to enhance the storage stability of cheddar cheese. The cricket protein (CP) samples pre-processed with microwave (T1), ultrasonication (T2) or without pre-treatment (T0) were used for developing the CPH using alcalase enzyme (3%). Freeze-dried CPH were incorporated in the cheese samples (CPH-T1, CPH-T2 and CPH-T0) at the maximum level of 1.5% and were analysed for quality during 3 months of storage (4 ± 1 °C) compared to the control samples without CPH. The pre-treatments significantly improved the antimicrobial and antioxidant potential of the CPH. The CPH exhibited a significant positive effect on antioxidant potential, lipid stability, protein oxidation, microbial growth, and sensory quality of the cheddar cheese during storage. Digestion simulation showed a significant positive impact on the antioxidant activity of the cheddar cheese. Our results indicate the potential of CPH to enhance the quality of fat-rich foods during storage.

The effect of maternal period nutritional status on oro-sensorial fat perception and taste preference in rats.

CD36 and GPR120 play an important role in the perception and preference for fat-rich food consumption. We aimed to investigate the relationship between oro-gustatory perception of lipids, fatty taste preference, and maternal (Gestation + Lactation)-maturation period nutrition status in offspring Sprague-Dawley rats. In our study, mother rats were fed with control (C) or high-fat diets (HFD) during gestation (21days) and lactation (21days) periods. After weaning, the offspring were fed with control (C) or high-fat diets (HFD) during the maturation (120days) period. Daily calorie intake and weekly body weight measurements were monitored. Two-bottle preference (TBPT) and licking tests measured the fat perceptions and preferences. Plasma levels of insulin, leptin, glucose, and triglyceride were measured. The protein and mRNA expressions of CD36 and GPR120 in the circumvallate papillae (CVP) were determined. The 48h TBPT results revealed that maternal HFD-exposed offspring rats significantly preferred 2% rapeseed oil solution regardless of the type of maturation diet. According to the licking test, C/C group (C diet exposed group in maternal and maturation periods) offspring licked 0.1% oleic acid-containing water more than C/HFD (C diet exposed in maternal period and HFD exposed group in maturation period) and HFD/HFD group. (HFD exposed group in maternal and maturation periods) groups. Plasma insulin and leptin concentrations significantly increased in HFD/HFD groups compared to C/C group. CD36 protein expressions were significantly lower in HFD/HFD than C/HFD and HFD/C groups. GPR120 and GNAT3 mRNA expressions in HFD/C group were significantly higher than in C/HFD group. Our results suggest that HFD exposure during maternal and maturation period may play a role in fat perception/preference through oral lipid sensors.

Television viewing and body fat distribution among Bengali school children of Kolkata, India

Background: Childhood obesity is considered as a major concern since a couple of decades. The increasing prevalence of childhood obesity is clear and concerns about the future health impact of childhood obesity are currently well documented. Low level of physical activity, high quantity of fat rich junk food consumption and prolonged leisure time with television (TV) viewing were reported to be significantly associated with obesity.&#x0D; Objective: The present study aims to evaluate the association of body fat distribution with television watching among school going Bengali children of Kolkata, India.&#x0D; Sample and Methods: 200 girls (aged 10-15 years) from a very heterogeneous background were selected from one state school. Data on socio-demographic aspects, TV viewing, computer use, physical activity and dietary pattern were collected by pretested questionnaire after obtaining prior consent from competent persons. Anthropometric measurements were taken following standard techniques.&#x0D; Results: Most of the participants preferred fat rich junk food and a few practice regular exercises. One-way ANOVA showed significant differences of body mass index (BMI), waist circumference (WC) and mid upper arm circumference (MUAC) between groups depending on the duration of TV viewing. The adiposity related variables were standardized by standard deviation score before the inferential analyses. Adjusted multiple linear regression showed positive effects of the duration of TV viewing on BMI (R2=0.233) and MUAC (R2=0.277).&#x0D; Conclusion: Irrespective of economic status, prolonged television watching leads to an adverse body fat distribution among teenage girls of Kolkata.

Is human obesity an inflammatory disease of the hypothalamus?

Obesity and its comorbidities are long-standing, challenging global health problems. Lack of exercise, overnutrition, and especially the consumption of fat-rich foods are some of the most important factors leading to an increase in prevalence in modern society. The pathophysiology of obesity as a metabolic inflammatory disease has moved into focus since new therapeutic approaches are required. The hypothalamus, a brain area responsible for energy homeostasis, has recently received special attention in this regard. Hypothalamic inflammation was identified to be associated with diet-induced obesity and new evidence suggests that it may be, beyond that, a pathological mechanism of the disease. This inflammation impairs the local signaling of insulin and leptin leading to dysfunction of the regulation of energy balance and thus, weight gain. After a high-fat diet consumption, activation of inflammatory mediators such as the nuclear factor κB or c-Jun N-terminal kinase pathway can be observed, accompanied by elevated secretion of pro-inflammatory interleukins and cytokines. Brain resident glia cells, especially microglia and astrocytes, initiate this release in response to the flux of fatty acids. The gliosis occurs rapidly before the actual weight gain. Dysregulated hypothalamic circuits change the interaction between neuronal and non-neuronal cells, contributing to the establishment of inflammatory processes. Several studies have reported reactive gliosis in obese humans. Although there is evidence for a causative role of hypothalamic inflammation in the obesity development, data on underlying molecular pathways in humans are limited. This review discusses the current state of knowledge on the relationship between hypothalamic inflammation and obesity in humans.