Age-related changes in the skin of the face and neck are the result of a number of interrelated biochemical processes occurring in various tissues (dermis and epidermis, subcutaneous fat, musculoskeletal apparatus and bone tissue). Currently, there are a number of minimally invasive techniques to correct age-related changes in the skin of the face, but the discussion regarding the clinical efficacy and duration of retention of the effect in correcting age-related facial changes continues. Poly-L-lactic acid (PLLA) is popular among specialists and is used as an effective method of correcting involutive changes in the skin of the face. This article presents an analysis of the data of modern literature devoted to the study of the effectiveness of the use of poly-L-lactic acid as a method of correcting age-related changes in the skin of the face. Currently, among the large group of drugs used in minimally invasive correction of age-related skin changes, PLLA is quite often used. However, despite the extensive experience of using PLLA in correcting age-related skin changes, there are not enough studies in foreign and domestic literature devoted to studying the duration of retention of the effect of PLLA-based drugs. The purpose of our study is to analyze the onset, retention and duration of the therapeutic lifting effect after administration of a PLLA-based drug using the Facial Volume Loss Scale (FVLS) and the Vectra 3D imaging system, in comparison with preparations based on hyaluronic acid, modified amino acids and exogenous collagen. Based on the data obtained, optimize the protocol of rejuvenation procedures for different morphotypes of aging. Keywords: polylactic acid, PLLA, aging.