Fast Steady-state Free Precession Research Articles

Sub‐second proton imaging of 13C hyperpolarized contrast agents in water

Indirect proton detection of (13)C hyperpolarized contrast agents potentially enables greater sensitivity. Presented here is a study of sub-second projection imaging of hyperpolarized (13)C contrast agent addressing the obstacle posed by water suppression for indirect detection in vivo. Sodium acetate phantoms were used to develop and test water suppression and sub-second imaging with frequency-selective RF pulses using spectroscopic and imaging indirect proton detection. A 9.8 mm aqueous solution of (13)C PHIP hyperpolarized 2-hydroxyethyl-(13)C-propionate-d2,3,3 (HEP), <P> ~25% was used for demonstration of indirect proton sub-second imaging detection. Balanced 2D FSSFP (fast steady-state free precession) allowed the recording of proton images with a field of view of 64 × 64 mm(2) and spatial resolution 2 × 2 mm(2) with total acquisition time of less than 0.2 s. In thermally polarized sodium 1-(13)C-acetate, (13) C to (1)H polarization transfer efficiency of 45.1% of the theoretically predicted values was observed in imaging detection corresponding to an 11-fold overall sensitivity improvement compared with direct (13)C FSSFP imaging. (13)C to (1)H polarization transfer efficiency of 27% was observed in imaging detection, corresponding to a 3.25-fold sensitivity improvement compared with direct (13)C FSSFP imaging with hyperpolarized HEP. The range of potential applications and limitations of this sub-second and ultra-sensitive imaging approach are discussed.

Evaluation of steady state free precession imaging of the pancreas

The aim of this work was to assess the diagnostic value of fast steady state free precession (SSFP) for the detection, characterization, and delineation of pancreatic lesions. Forty-eight patients referred for magnetic resonance (MR) imaging of the pancreas were included in the study. In addition to the standard protocol, axial pre-contrast SSFP slices of the pancreas were acquired. The standard of reference was defined as based on all imaging data other than SSFP, histopathology, surgery, and/or clinical follow-up. A randomized consensus reading of the SSFP data sets was retrospectively conducted by two board-certified radiologists. The presence of pancreatic lesions, local infiltration, and lymph node metastases was evaluated. Sensitivity and specificity were calculated and a receiver operating characteristic (ROC) analysis was performed. The overall sensitivity and specificity of SSFP were 0.93 and 0.77, respectively. Comparable values were achieved for lymph node detection (0.88/0.91) and assessment of vascular infiltration (0.94/0.91). The mean area under the ROC curve (Az) was 0.91. Owing to its potential to detect vascular infiltration and the rapid acquisition time, SSFP imaging should be supplemented as part of a standard MR protocol of the pancreas.

Localized volume selection technique using an additional radial gradient coil.

A volume selection technique for the localized NMR imaging using an additional radial gradient is proposed. This volume selection gradient is the fourth gradient in addition to the usual 3-dimensional imaging gradients, i.e., x-, y-, and z-directional gradients, and is of the radial form. The principle of the proposed method is the use of the radial gradient in conjunction with the selective RF pulse thereby selecting a small cylindrical volume which can be used for the 3-dimensional volume imaging with fewer encoding steps than those of the conventional full 3-dimensional volume imaging. The present technique combined with the fast steady state free precession gradient echo imaging sequence allows us to reduce the total scan time to several minutes for the 3-dimensional volume imaging with the spatial resolution of 1 x 1 x 1 mm or to spend the same scan time for the 3-dimensional imaging with improved spatial resolution. The basic principle of the radial gradient coil consisting of a main circular loop coil and an offset compensating Helmholtz coil is discussed and the construction details are presented. Some experimental results of the proposed volume selection imaging technique as well as computer simulation results are also given.