The aims of this study were to compare the effects of meniscectomy and autogenous graft replacement on the functions and histology of the Rhesus monkey temporomandibular joint. Eight matured Rhesus monkeys (Macaca mulatta) were used for the first part of the study to compare firstly the results of meniscectomy without replacement and secondly, replacement of the disc with a fascia lata graft. The results showed that unilateral meniscectomy in Rhesus monkeys did not result in significant morbidity. Degenerative changes (osteoarthritis) were observed in all the experimental joints with and without replacement of the articular discs. Fascia lata did not survive after grafting and did not reliably induce re-formation of an articular disc-like structure.