Malaria (P. falciparum, P. vivax) is a major vector borne disease in Mizoram. Since the extreme weather conditions and changing climate have a major role in the spread of vector borne illnesses, the purpose of this study aimed to examine the changing trend of climate and the relationship between climatic variables and epidemiological malaria situation in Mizoram. The Mann-Kendall and Sen’s slope test were employed to analyze the changing trend on rainfall and humidity, the climatic data were collected from Indian Meteorological Department, Aizawl (1986-2019) and multiple regression model has been utilized to observe the correlation between instances of malaria and climatic factors (2000-2019). The data on epidemiological malaria cases were obtained from Health and Family Welfare Department, Govt. of Mizoram. The Mann-Kendall results show declining trend in rainfall with -4.58 magnitude of rainfall annually and an increase in the annual relative humidity with 0.19% (p <0.1). The regression model shows a highly significant association between the climatic variables and the malaria situation showing p<0.05.