Family Of Antitumor Antibiotics Research Articles

Abstract 2453: The role of p21 in the toxicity of mitomycin C and decarbamoylmitomycin C

Abstract The mitomycins are a family of antitumor antibiotics made by Streptomyces. One member of this family, mitomycin C (MC), is currently used to treat certain cancers. Its mode of action has been extensively examined. In comparison, 10-decarbamoyl mitomycin C (DMC) has not been the object of such intense investigation. It has recently been found to form similar or identical adducts with DNA as mitomycin C (MC). In particular, DMC generates a unique stereoisomeric interstrand crosslink (beta isomer, β-ICL). Although the DNA-adducts of both drugs share common structural features, the biochemical responses to the two drugs are different. In particular, contrary to MC, the DNA-adducts generated by DMC treatment (β-ICL) rapidly activate a p53-independent signal transduction pathway. Thus, the study MC-DMC provides an ideal model for identifying structural features determining the cell signaling outcome in the presence or the absence of a functioning p53 pathway. In particular, we are interested in correlating MC and DMC-adducts structures with the role of p21 in the toxicity of the α-ICL and β-ICL. In this report, we present the following preliminary results 1) Synthesis of the beta DNA monoadduct of DMC via post-oligomerization methods 2) Role of p21 in the upstream p53-independent signaling pathway in response to MC/DMC and the α-ICL. Citation Format: Elise Champeil, Shu-Yuan Cheng, Bik Tzu Huang, Jiwon Seo. The role of p21 in the toxicity of mitomycin C and decarbamoylmitomycin C. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2453. doi:10.1158/1538-7445.AM2015-2453

Modified bleomycin disaccharides exhibiting improved tumor cell targeting.

The bleomycins (BLMs) are a family of antitumor antibiotics used clinically for anticancer chemotherapy. Their antitumor selectivity derives at least in part from their ability to target tumor cells, a property that resides in the carbohydrate moiety of the antitumor agent. In earlier studies, we have demonstrated that the tumor cell selectivity resides in the mannose carbamoyl moiety of the BLM saccharide and that both the BLM disaccharide and monosaccharide containing the carbamoyl moiety were capable of the delivery/uptake of a conjugated cyanine dye into cultured cancer cell lines. Presently, the nature of the participation of the carbamoyl moiety has been explored further to provide compounds of utility for defining the nature of the mechanism of tumor cell recognition and uptake by BLM saccharides and in the hope that more efficient compounds could be identified. A library of seven disaccharide–Cy5** dye conjugates was prepared that are structural analogues of the BLM disaccharide. These differed from the natural BLM disaccharide in the position, orientation, and substitution of the carbamoyl group. Studies of these compounds in four matched sets of tumor and normal cell lines revealed a few that were both tumor cell selective and internalized 2–4-fold more efficiently than the natural BLM disaccharide.

Terpentecin and ECT4B, new family of topoisomerase II targeting antitumor antibiotics produced by Streptomyces: producing organism, fermentation and large scale purification.

Terpentecin and UCT4B are new family of antitumor antibiotics with topoisomerase II mediated DNA cleavage activity. Based on the taxonomic studies, the producing strain S-464 was identified as Streptomyces sp. This strain is different from Kitasatosporia griseola which had been identified as the terpentecin-producing strain in 1988. Fermentation studies showed that natural nitrogen sources supported higher titer of terpentecin, and the synthetic medium with inorganic nitrogen sources supported selective production of UCT4B. An improved isolation method was developed for the large scale purification of terpentecin.

Calicheamicins, a novel family of antitumor antibiotics. 4. Structure elucidation of calicheamicins .beta.1Br, .gamma.1Br, .alpha.2I, .alpha.3I, .beta.1I, .gamma.1I, and .delta.1I

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCalicheamicins, a novel family of antitumor antibiotics. 4. Structure elucidation of calicheamicins .beta.1Br, .gamma.1Br, .alpha.2I, .alpha.3I, .beta.1I, .gamma.1I, and .delta.1IMay D. Lee, Theresa S. Dunne, Conway C. Chang, Marshall M. Siegel, George O. Morton, George A. Ellestad, William J. McGahren, and Donald B. BordersCite this: J. Am. Chem. Soc. 1992, 114, 3, 985–997Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://doi.org/10.1021/ja00029a030RIGHTS & PERMISSIONSArticle Views612Altmetric-Citations110LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts

LL-D49194 antibiotics, a novel family of antitumor agents. Taxonomy, fermentation and biological properties.

A novel family of antitumor antibiotics, designated LL-D49194, was isolated from the fermentation broth of an actinomycete strain identified as Streptomyces vinaceus-drappus. LL-D49194 alpha 1 and beta 2 were active against Gram-positive and inactive against Gram-negative bacteria in vitro. The beta 1 component was not active against either Gram-positive or Gram-negative bacteria. These antibiotics exhibited significant in vivo activities against several murine tumors, albeit with differing potencies.

ChemInform Abstract: Esperamicins, a Novel Class of Potent Antitumor Antibiotics. Part 2 and 3. Calichemicins, a Novel Family of Antitumor Antibiotics. Part 1 and 2

ChemInformVolume 20, Issue 15 Reviews ChemInform Abstract: Esperamicins, a Novel Class of Potent Antitumor Antibiotics. Part 2 and 3. Calichemicins, a Novel Family of Antitumor Antibiotics. Part 1 and 2 L. L. KIESSLING, L. L. KIESSLING Yale Univ., New Haven, CT, USASearch for more papers by this authorS. L. SCHREIBER, S. L. SCHREIBER Yale Univ., New Haven, CT, USASearch for more papers by this author L. L. KIESSLING, L. L. KIESSLING Yale Univ., New Haven, CT, USASearch for more papers by this authorS. L. SCHREIBER, S. L. SCHREIBER Yale Univ., New Haven, CT, USASearch for more papers by this author First published: April 11, 1989 https://doi.org/10.1002/chin.198915351Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume20, Issue15April 11, 1989 RelatedInformation

Calicheamicins, a novel family of antitumor antibiotics: taxonomy, fermentation and biological properties.

A novel family of antitumor antibiotics, the calicheamicins, were isolated from the fermentation broth of Micromonospora echinospora subsp. calichensis. These antibiotics exhibited significant activity against Gram-positive and Gram-negative bacteria in vitro. Calicheamicin gamma 1I demonstrated antitumor activity against P388 leukemia and B16 melanoma in vivo.

Calicheamicins, a novel family of antitumor antibiotics. 3. Isolation, purification and characterization of calicheamicins beta 1Br, gamma 1Br, alpha 2I, alpha 3I, beta 1I, gamma 1I and delta 1I.

Novel antitumor antibiotics, calicheamicins beta 1Br, gamma 1Br, alpha 2I, alpha 3I, beta 1I, gamma 1I and delta 1I were recovered from the fermentation broth of Micromonospora echinospora ssp. calichensis by solvent extraction, selective precipitation, normal phase, reversed phase and partition chromatography. The individual components were characterized by their UV, IR, 1H and 13C NMR spectral data.

ChemInform Abstract: Calichemicins, a Novel Family of Antitumor Antibiotics. Part 1. Chemistry and Partial Structure of Calichemicin γ1I.

AbstractThe structure of the title compound, the major component of the calichemicin complex (isolated from Micromonospora echinospora ssp.

ChemInform Abstract: Calichemicins, a Novel Family of Antitumor Antibiotics. Part 2. Chemistry and Structure of Calichemicin γ1I.

ChemInform Abstract: Calichemicins, a Novel Family of Antitumor Antibiotics. Part 2. Chemistry and Structure of Calichemicin γ1I.

Calichemicins, a novel family of antitumor antibiotics. 2. Chemistry and structure of calichemicin .gamma.1I

Calichemicins, a novel family of antitumor antibiotics. 2. Chemistry and structure of calichemicin .gamma.1I

Calichemicins, a novel family of antitumor antibiotics. 1. Chemistry and partial structure of calichemicin .gamma.1I

Calichemicins, a novel family of antitumor antibiotics. 1. Chemistry and partial structure of calichemicin .gamma.1I