Familiarity-based Recognition Research Articles

Soliciting judgments of learning reactively facilitates both recollection- and familiarity-based recognition memory

Soliciting judgments of learning reactively facilitates both recollection- and familiarity-based recognition memory

Schema-congruency supports the formation of unitized representations: Evidence from event-related potentials

The main goal of the present study was to investigate whether schema-based encoding of novel word pairs (i.e., novel compound words) supports the formation of unitized representations and thus, associative familiarity-based recognition. We report two experiments that both comprise an incidental learning task, in which novel noun-noun compound words were presented in semantically congruent contexts, enabling schema-supported processing of both constituents, contrasted with a schema-neutral condition. In Experiment 1, the effects of schema congruency on memory performance were larger for associative memory performance than for item memory performance in a memory test in which intact, recombined, and new compound words had to be discriminated. This supports the view that schema congruency boosts associative memory by promoting unitization. When contrasting event-related potentials (ERPs) for hits with correct rejections or associative misses, an N400 attenuation effect (520–676 ms) indicating absolute familiarity was present in the congruent condition, but not in the neutral condition. In line with this, a direct comparison of ERPs on hits across conditions revealed more positive waveforms in the congruent than in the neutral condition. This suggests that absolute familiarity contributes to associative recognition memory when schema-supported processing is established. In Experiment 2, we tested whether schema congruency enables the formation of semantically overlapping representations. Therefore, we included semantically similar lure compound words in the test phase and compared false alarm rates to these lures across conditions. In line with our hypothesis, we found higher false alarm rates in the congruent as compared to the neutral condition. In conclusion, we provide converging evidence for the view that schema congruency enables the formation of unitized representations and supports familiarity-based memory retrieval.

The role of recollection, familiarity, and the hippocampus in episodic and working memory

The hippocampus plays an essential role in long-term episodic memory by supporting the recollection of contextual details, whereas surrounding regions such as the perirhinal cortex support familiarity-based recognition discriminations. Working memory - the ability to maintain information over very brief periods of time - is traditionally thought to rely heavily on frontoparietal attention networks, but recent work has shown that it can also rely on the hippocampus. However, the conditions in which the hippocampus becomes involved in working memory tasks are unclear and whether it contributes to recollection or familiarity-based responses in working memory is only beginning to be explored. In the current paper, we first review and contrast the existing amnesia literature examining recollection and familiarity in episodic and working memory. The results indicate that recollection and familiarity contribute to both episodic and working memory. However, in contrast to episodic memory, in working memory the hippocampus is particularly critical for familiarity-based rather than recollection-based discrimination. Moreover, the results indicate that the role of the hippocampus in working memory can be obscured due to ‘criterion-induced process-masking’ because it primarily supports intermediate-confidence recognition decisions. We then report results from a new working memory study examining the ability of amnesics to detect global and local changes in novel complex objects (i.e., fribbles), which indicates that the hippocampus plays an especially critical role in working memory when the task requires the detection of global rather than discrete changes. We conclude by considering the results in light of neurocomputational models and proposing a general framework for understanding the relationship between episodic and working memory.

The anterior medial hippocampus contributes to both recall and familiarity-based memory for scenes

The hippocampus is usually associated with recall memory, whereas its contribution to familiarity-based memory is debated. Growing evidence support the idea that this structure participates to any cognitive process performed on scene representations. In parallel, differences in functional specialisation and cortical connectivity were found across the longitudinal and transverse axes of the hippocampus. Here we reanalysed functional MRI data from 51 participants showing stronger engagement of the hippocampus in recall, familiarity-based recognition and rejection, and visual discrimination, of scenes compared to single objects. A conjunction analysis between these four tasks revealed a set of occipital, medial temporal, posterior cingulate, and parietal regions, matching the scene construction network described in the literature. Crucially, we found that the anterior medial part of the hippocampus was consistently involved in all tasks investigated for scene stimuli. These findings support that the hippocampus can contribute to both recall and familiarity-based memory, depending on stimulus type. More generally, this bolsters the recent proposal that circumscribed regions within the hippocampus may underpin specific cognitive mechanisms.

Converging diencephalic and hippocampal supports for episodic memory

To understand the neural basis of episodic memory it is necessary to appreciate the significance of the fornix. This pathway creates a direct link between those temporal lobe and medial diencephalic sites responsible for anterograde amnesia. A collaboration with Andrew Mayes made it possible to recruit and scan 38 patients with colloid cysts in the third ventricle, a condition associated with variable fornix damage. Complete fornix loss was seen in three patients, who suffered chronic long-term memory problems. Volumetric analyses involving all 38 patients then revealed a highly consistent relationship between mammillary body volume and the recall of episodic memory. That relationship was not seen for working memory or tests of recognition memory. Three different methods all supported a dissociation between recollective-based recognition (impaired) and familiarity-based recognition (spared). This dissociation helped to show how the mammillary body-anterior thalamic nuclei axis, as well as the hippocampus, is vital for episodic memory yet is not required for familiarity-based recognition. These findings set the scene for a reformulation of temporal lobe and diencephalic amnesia. In this revised model, these two regions converge on overlapping cortical areas, including retrosplenial cortex. The united actions of the hippocampal formation and the anterior thalamic nuclei on these cortical areas enable episodic memory encoding and consolidation, impacting on subsequent recall.

Conscious awareness and memory systems in the brain.

The term "memory" typically refers to conscious retrieval of events and experiences from our past, but experience can also change our behaviour without corresponding awareness of the learning process or the associated outcome. Based primarily on early neuropsychological work, theoretical perspectives have distinguished between conscious memory, said to depend critically on structures in the medial temporal lobe (MTL), and a collection of performance-based memories that do not. The most influential of these memory systems perspectives, the declarative memory theory, continues to be a mainstay of scientific work today despite mounting evidence suggesting that contributions of MTL structures go beyond the kinds or types of memory that can be explicitly reported. Consistent with these reports, more recent perspectives have focused increasingly on the processing operations supported by particular brain regions and the qualities or characteristics of resulting representations whether memory is expressed with or without awareness. These alternatives to the standard model generally converge on two key points. First, the hippocampus is critical for relational memory binding and representation even without awareness and, second, there may be little difference between some types of priming and explicit, familiarity-based recognition. Here, we examine the evolution of memory systems perspectives and critically evaluate scientific evidence that has challenged the status quo. Along the way, we highlight some of the challenges that researchers encounter in the context of this work, which can be contentious, and describe innovative methods that have been used to examine unconscious memory in the lab. This article is categorized under: Psychology > Memory Psychology > Theory and Methods Philosophy > Consciousness.

Task context dissociates the FN400 and the N400.

In event-related potential studies, familiarity-based recognition has been associated with the FN400, that is, more positive-going waveforms for old items than new items 300-500 ms post-stimulus onset, maximal at frontal electrodes. We tested the proposition that the FN400 reflects the attribution of unexpected processing fluency to familiarity. This implies that the FN400 is greater when fluency is less expected, that is, for less familiar stimuli. Moreover, the FN400 should be modulated by the goal of remembering and only elicited when fluency is correctly attributed to the past, that is, by correct old responses in recognition memory tests. In the absence of a retrieval task, enhanced fluency for repeated items should be associated with an N400 attenuation as no episodic attribution takes place. In an incidental study-test design with words of low and high life-time familiarity, participants made pleasantness judgments for half of the studied words. The other half re-appeared in a recognition test. Only in the latter task, participants had the goal of remembering. As both tasks included also new words, we could compare old/new effects under conditions in which both effects are driven by increased fluency for repeated words. We did not find the expected differences in the FN400 for low vs. high life-time familiarity items. However, as expected, we found a frontally distributed FN400 in the recognition test whereas the old/new effect in the pleasantness task resembled an N400 effect. This supports the view that the FN400 occurs when fluency is attributed to familiarity during a recognition decision.

Object memory is multisensory: Task-irrelevant sounds improve recollection

Hearing a task-irrelevant sound during object encoding can improve visual recognition memory when the sound is object-congruent (e.g., a dog and a bark). However, previous studies have only used binary old/new memory tests, which do not distinguish between recognition based on the recollection of details about the studied event or stimulus familiarity. In the present research, we hypothesized that hearing a task-irrelevant but semantically congruent natural sound at encoding would facilitate the formation of richer memory representations, resulting in increased recollection of details of the encoded event. Experiment 1 replicates previous studies showing that participants were more confident about their memory for items that were initially encoded with a congruent sound compared to an incongruent sound. Experiment 2 suggests that congruent object-sound pairings specifically facilitate recollection and not familiarity-based recognition memory, and Experiment 3 demonstrates that this effect was coupled with more accurate memory for audiovisual congruency of the item and sound from encoding rather than another aspect of the episode. These results suggest that even when congruent sounds are task-irrelevant, they promote formation of multisensory memories and subsequent recollection-based retention. Given the ubiquity of encounters with multisensory objects in our everyday lives, considering their impact on episodic memory is integral to building models of memory that apply to naturalistic settings.

Word recognition memory and serum levels of Borna disease virus specific circulating immune complexes in obsessive–compulsive disorder

BackgroundBorna disease virus 1 (BoDV-1) is a non-segmented, negative-strand RNA virus that persistently infects mammals including humans. BoDV-1 worldwide occurring strains display highly conserved genomes with overlapping genetic signatures between those of either human or animal origin. BoDV-1 infection may cause behavioral and cognitive disturbances in animals but has also been found in human major depression and obsessive–compulsive disorder (OCD). However, the impact of BoDV-1 on memory functions in OCD is unknown.MethodTo evaluate the cognitive impact of BoDV-1 in OCD, event-related brain potentials (ERPs) were recorded in a continuous word recognition paradigm in OCD patients (n = 16) and in healthy controls (n = 12). According to the presence of BoDV-1-specific circulating immune complexes (CIC), they were divided into two groups, namely group H (high) and L (low), n = 8 each. Typically, ERPs to repeated items are characterized by more positive waveforms beginning approximately 250 ms post-stimulus. This “old/new effect” has been shown to be relevant for memory processing. The early old/new effect (ca. 300–500 ms) with a frontal distribution is proposed to be a neural correlate of familiarity-based recognition. The late old/new effect (post-500 ms) is supposed to reflect memory recollection processes.ResultsOCD patients were reported to show a normal early old/new effect and a reduced late old/new effect compared to normal controls. In our study, OCD patients with a high virus load (group H) displayed exactly these effects, while patients with a low virus load (group L) did not differ from healthy controls.ConclusionThese results confirmed that OCD patients had impaired memory recollection processes compared to the normal controls which may to some extent be related to their BoDV-1 infection.

Impaired recollection and initially preserved familiarity in a patient with bilateral fornix transection following third ventricle colloid cyst removal: A two-year follow-up study

Objective Recognition memory is widely accepted as a dual process-based model, namely familiarity and recollection. However, the location of their specific neurobiological substrates remains unclear. Similar to hippocampal damage, fornix damage has been associated with recollection memory but not familiarity memory deficits. To understand the neural basis of recognition memory, determining the importance of the fornix and its hippocampal connections is essential. Methods Recognition memory was examined in a 45-year-old male who underwent a complete bilateral fornix section following the removal of a third ventricle colloid cyst. The application of familiarity and recollection for recognition memory decisions was investigated via an immediate and delayed associative recognition test and an immediate and delayed forced-choice task in the patient and a control group (N = 15) over a two-year follow-up period. Complete demographic, neuropsychological, neuropsychiatric, and neuroradiological characterizations of this patient were performed. Results Persistent immediate and delayed verbal recollection memory deficits were observed in the patient. Moreover, delayed familiarity-based recognition memory declined gradually over the follow-up period, immediate familiarity-based recognition memory was unaffected, and reduced non-verbal memory improved. Conclusion The present findings support models that the extended hippocampal system, including the fornices, does not appear to play a role in familiarity memory but is particularly important for recollection memory. Moreover, our study suggests that bilateral fornix transection may be associated with relatively functional recovery of non-verbal memory.

Recollection, familiarity, and behavioural pattern separation: A correlational study.

ABSTRACT The relationship between recognition and pattern discrimination is not fully understood, and research on the relationships between these two processes is sparse. It has been generally assumed that pattern separation allows for recollection-based recognition. However, recent research has called this assumption into question. Therefore, the need for more research on this topic is evident. In the present study, we sought to investigate relationships between recollection- and familiarity-based recognition and behavioural pattern separation in healthy young adults. Participants (N = 146) completed two recognition tasks on a computer. The first was a word-pair recognition task involving unrelated and unitised word pairs (designed to measure recollection and familiarity, respectively), and the second was a mnemonic similarity test involving old, new, and similar (lure) object images (designed to measure behavioural pattern separation and completion). Correlation analyses showed that both recollection- and familiarity-based recognition were positively related to behavioural pattern separation. Regression analyses showed that, while controlling for familiarity, behavioural pattern separation was still predictive of recollection. However, while controlling for recollection, behavioural pattern separation was no longer predictive of familiarity. These findings support theoretical assumptions linking pattern separation to recollection.

Novelty processing associated with neural beta oscillations improves recognition memory in young and older adults.

Novelty anticipation activates the mesolimbic system and promotes subsequent long-term memory in younger adults. Importantly, mesolimbic structures typically degenerate with age, which might reduce positive effects of novelty anticipation. Here, we used electroencephalography in combination with an established paradigm in healthy young (19-33 years old, n=28) and older (53-84, n=27) humans. Colored cues predicted the subsequent presentation of either a novel or previously familiarized image (75% cue validity). On the subsequent day, recognition memory for the novel images was tested. Behaviorally, novelty anticipation improved recollection-based but not familiarity-based recognition memory in both groups, and this effect was more pronounced in older subjects. Furthermore, novelty and familiarity cues increased theta (4-8 Hz) and decreased alpha/beta power (9-20 Hz); at outcome, expected novel and familiar images both increased beta power (13-25 Hz). Finally, a subsequent memory effect for expected novel images was associated with increases in beta power independent of age. Together, novelty anticipation drives hippocampus-dependent long-term recognition memory across the life span, and this effect appears to be related to neural beta oscillations.

The effect of test query on recognition event-related potentials (ERPs)

The influence of question framing (i.e., [was the item] “old?” or “new?”) on recognition memory and event-related potentials (ERPs) was investigated. Words were encoded using a shallow task to create a weak memory trace that was more susceptible to test question framing effects. Participants made yes/no judgments on two, counterbalanced tests. One test focused on old items (“old?”), whereas the other test focused on new items (“new?”). The behavioral evidence suggested that the weak memory traces led to more familiarity-based recognition judgments with a concentrated effect on decision criterion. There were some small ERP changes on the FN400 or LPC consistent with the criterion changes, but the test query did not directly alter these ERP components. Instead, the test query altered a late old/new ERP difference similar to the “right frontal old/new effect” reported in source monitoring ERP studies. When the query was “new?”, old items elicited more positive ERPs, whereas there was no old/new difference when the query was “old?”. The results suggest that the query framing induces memory biases that occur late in the stream of processing. More generally, the results indicate that decision criterion must be accounted for when interpreting physiological correlates of recognition memory.

Cooperatively breeding banded mongooses do not avoid inbreeding through familiarity-based kin recognition

In species that live in family groups, such as cooperative breeders, inbreeding is usually avoided through the recognition of familiar kin. For example, individuals may avoid mating with conspecifics encountered regularly in infancy, as these likely include parents, siblings, and closely related alloparents. Other mechanisms have also been reported, albeit rarely; for example, individuals may compare their own phenotype to that of others, with close matches representing likely relatives (“phenotype matching”). However, determinants of the primary inbreeding avoidance mechanisms used by a given species remain poorly understood. We use 24 years of life history and genetic data to investigate inbreeding avoidance in wild cooperatively breeding banded mongooses (Mungos mungo). We find that inbreeding avoidance occurs within social groups but is far from maximised (mean pedigree relatedness between 351 breeding pairs = 0.144). Unusually for a group-living vertebrate, we find no evidence that females avoid breeding with males with which they are familiar in early life. This is probably explained by communal breeding; females give birth in tight synchrony and pups are cared for communally, thus reducing the reliability of familiarity-based proxies of relatedness. We also found little evidence that inbreeding is avoided by preferentially breeding with males of specific age classes. Instead, females may exploit as-yet unknown proxies of relatedness, for example, through phenotype matching, or may employ postcopulatory inbreeding avoidance mechanisms. Investigation of species with unusual breeding systems helps to identify constraints against inbreeding avoidance and contributes to our understanding of the distribution of inbreeding across species.Significance statementChoosing the right mate is never easy, but it may be particularly difficult for banded mongooses. In most social animals, individuals avoid mating with those that were familiar to them as infants, as these are likely to be relatives. However, we show that this rule does not work in banded mongooses. Here, the offspring of several mothers are raised in large communal litters by their social group, and parents seem unable to identify or direct care towards their own pups. This may make it difficult to recognise relatives based on their level of familiarity and is likely to explain why banded mongooses frequently inbreed. Nevertheless, inbreeding is lower than expected if mates are chosen at random, suggesting that alternative pre- or post-copulatory inbreeding avoidance mechanisms are used.

Distinct FN400/N400 memory effects for perceptually fluent and disfluent words

Recognition memory studies have shown that increased perceptual fluency results in more “old” responses and, presumably, increases familiarity. However, the exact neural mechanisms of these effects remain unresolved. We conducted two ERP experiments in which participants encoded words and performed a recognition test where fluency was manipulated by changing clarity of test words (half of them were clear or blurry). In the more demanding Experiment 1, we found a reversed effect of fluency on recognition (more hits for blurry words), which was accompanied by larger N400 and LPC old/new effects for blurry words. For high confidence responses, the topography of N400 shifted towards frontal electrodes (the FN400 for blurry words). In the less demanding Experiment 2, no behavioral differences between clear and blurry words were observed. However, there was a discrepancy in the ERP results, with the frontal FN400 for blurry words and the parietal N400 for clear words, suggesting that distinct neural pathways can support familiarity-based recognition for clear and blurry items. In both experiments, early perceptual fluency ERP effects were also observed. The results indicate that both semantic processing and familiarity can be enhanced by perceptual fluency and contribute to recognition judgments, depending on the interpretations of fluency.

Unitization could facilitate item recognition but inhibit verbatim recognition for picture stimuli: behavioral and event-related potential study.

It is widely accepted that unitization can promote familiarity-based associative recognition, but the effect of unitization on item recognition remains unclear. The goals of this study were to elaborate on how unitization affected item recognition and the neural correlates of familiarity and recollection for item recognition. In study, the participants were asked to learn related and unrelated picture pairs, and in test, they were required to distinguish single old pictures form new pictures. In experiment 1, we used R/K/N paradigm to estimate the contribution of familiarity and recollection to item recognition, the results showed that unitization could improve item recognition through increasing recollection selectively. In experiment 2, we used ERP old/new effects to estimate the neural correlates of familiarity and recollection, the results showed that unitization could improve item recognition through a selective reduction in LPC effect. Inspired by DRM paradigm, in experiment 3, we divided the new pictures into semantically related lure pictures and semantically unrelated new pictures to explore the effects of unitization on item recognition and verbatim recognition (the ability to distinguish old pictures from lure pictures). The behavioral results showed that unitization could improve item recognition, but it damaged verbatim recognition. The ERP results revealed that there were larger LPC effects in the unrelated condition than in the related condition, regardless of item or verbatim recognition. In summary, we believed that unitization could indeed improve item recognition, but it damaged verbatim recognition.

The spatial distribution of attention predicts familiarity strength during encoding and retrieval.

The memories we form are determined by what we attend to, and conversely, what we attend to is influenced by our memory for past experiences. Although we know that shifts of attention via eye movements are related to memory during encoding and retrieval, the role of specific memory processes in this relationship is unclear. There is evidence that attention may be especially important for some forms of memory (i.e., conscious recollection), and less so for others (i.e., familiarity-based recognition and unconscious influences of memory), but results are conflicting with respect to both the memory processes and eye movement patterns involved. To address this, we used a confidence-based method of isolating eye movement indices of spatial attention that are related to different memory processes (i.e., recollection, familiarity strength, and unconscious memory) during encoding and retrieval of real-world scenes. We also developed a new method of measuring the dispersion of eye movements, which proved to be more sensitive to memory processing than previously used measures. Specifically, in 2 studies, we found that familiarity strength-that is, changes in subjective reports of memory confidence-increased with (a) more dispersed patterns of viewing during encoding, (b) less dispersed viewing during retrieval, and (c) greater overlap in regions viewed between encoding and retrieval (i.e., resampling). Recollection was also related to these eye movements in a similar manner, though the associations with recollection were less consistent across experiments. Furthermore, we found no evidence for effects related to unconscious influences of memory. These findings indicate that attentional processes during viewing may not preferentially relate to recollection, and that the spatial distribution of eye movements is directly related to familiarity-based memory during encoding and retrieval. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

The interaction of relational encoding and unitization: Effects on medial temporal lobe processing during retrieval

In retrieval of typical episodic memories, recollection leads to retrieval of context details whereas familiarity is only diagnostic for item memory. Unitization is an encoding strategy that allows context details to be processed as item features and therefore increases the involvement of familiarity-based recognition in retrieval of these context details. Relational encoding is a hippocampally-dependent process that stores items and contexts independently. Our previous study Tu and Diana [1] concluded that mixing unitized and non-unitized context details in the same episode reduced the contribution of familiarity to retrieval of any one detail. In the current study, we modified the paradigm by removing visual cues to the context details and the condition-specific blocking during test. Surprisingly, the behavioral data diverged from our 2016 study and indicated that the two manipulated context details in the modified paradigm were processed independently of one another. Neuroimaging data further revealed anterior hippocampal activation was associated with unitization of source information as compared to relational encoding. We also found the predicted increase in bilateral perirhinal cortex activation and decrease in parahippocampal cortex activation during retrieval of unitized color information when compared to relationally-encoded color information. We did not find that same predicted pattern of differences due to unitization of size information.

Evaluating the Association of High Trait Anxiety With a Bias in Familiarity-Based Recognition of Emotional Stimuli

Abstract. In the past decades the role of cognitive biases as maintaining factors of anxiety has been widely researched. This theoretical framework assumes that vulnerability self-referential thoughts promote a hyper-vigilant mode of processing environmental stimuli. In this mode, threatening information increases attentional capture and therefore encoding and retrieval of such stimuli is enhanced. Although this attentional bias has been confirmed, the evidence concerning the memory bias is contradictory. Our hypothesis is that the bias in memory is expressed through the pattern of recognition. Particularly, the aim of this study was to evaluate the association of anxiety with familiarity, a deficient form of recognition which consists only in the identification of the item without retrieval of contextual information. Two groups of 17 participants with low and high anxiety levels performed an experimental task of visual recognition memory, using neutral, positive, and negative pictures. The experiment had two test phases, with a 24-hour interval, to evaluate possible effects of consolidation. The pattern of recognition was measured, behaviorally (through an independent Remember/Know paradigm) and through event-related potentials (ERP). Participants with higher levels of anxiety developed a bias in recognition of arousing stimuli (positive and negative) compared with the control group. This bias was observed behaviorally through an increase of familiarity-based recognition, and was associated with a positive modulation of a right parietal late positive component (LPC) at approximately 600 ms of latency. Participants with higher levels of anxiety are capable of recognizing arousing stimuli but lack efficiency in retrieving past contextual information compared to lower level anxiety participants. A recognition bias can be the first step in cognitive distortions that generate anxiety. This is, to our knowledge, the first study to explore the association of anxiety with familiarity-based recognition, using an independent Remember/Know paradigm combined with electrophysiological data. Further studies with bigger samples and more recording channels are needed to confirm the electrophysiological findings.

Wakeful rest promotes the viewpoint-invariance, but not the fine discriminability, of entities mnemonic representations for subsequent familiarity-based recognition

Wakeful rest promotes the viewpoint-invariance, but not the fine discriminability, of entities mnemonic representations for subsequent familiarity-based recognition