The essence of personal and professional self-development of pedagogical workers is described in the paper as an activity aimed at transforming oneself as a subject of professional activity, improving one’s professional competence and developing professionally significant personal qualities. The authors carry out an empirical study on factors of personal and professional self-development among pedagogical workers of educational institutions for children with disabilities. Taking the polydeterminism of personal and professional self-development into account, the authors identify and compare the subject and object factors of self-development among teaching staff of organisations for students with disabilities and workers without work experience in these organisations. The basic factors of self-development for teachers and specialists of educational organisations for children with disabilities are: readiness for selfdevelopment as integrative personal education, novelty in activities, as well as attention of the leader to the problems of development and improvement of employees.