Factors Of Health-related Quality Research Articles

Predictors of Health Related Quality of Life of Thyroid Cancer Patients

Background : Having the normal life expectancy of thyroid cancer patients, there are great concerns about any impairment in health-related quality of life (HRQOL) during the follow-up period. The aim of this study is to determine the potential predicting factors of health related quality of life (HRQOL) of thyroid cancer patients.
 Methods : Total 246 thyroid cancer patients in two tertiary level hospitals in Dhaka city were involved in this cross sectional study from 01 July 2018 to 30 June 2019. Data were collected purposively by face-to-face interview with semi-structured questionnaire andchecklist. Data were analyzed by the statistical package for the social science (SPSS) version 23.
 Results : Study revealed that mean (±SD) age of the respondent was 37.85(±12.20) years (range 14-70 years).Majority 74.4% of respondents was female, married (72%), housewife (61.4%),primary education (69%) and mean (±SD) monthly family income was Tk. 17681(±10602).Approximately 82.9% of patients had papillary cancer and 17.1% had follicular cancer. Of the patients, 91.5% had neck swelling, 41.9% had swollen lymph node, 57.3% had dysphonia and 35.4% had dysphagia.The mean overall HRQOL in thyroid cancer patients was 73.7(±8.39). HRQOL score of students and higher educated persons were better among the respective groups (p <.001).Multivariate regression analysis revealed that education (β=-0.888, p<.05), family income (β=0.05, p<.05) and marital status (β=-0.1.384, p<.05) and clinical condition (β=-0.522, p<.05) were potential predictors of HRQOLof thyroid cancer patients.
 Conclusion : The overall HRQOL score was considerably good in this study. Family income, marital status, education and clinical condition had emerged as strong predictors in HRQOL of thyroid cancer patients. Proper diagnosis, motivation and attending clinical condition may significantly improve the HRQOL of thyroid cancer patients.
 AKMMC J 2021; 12(2): 76-81

Quality of Life among Patients with Retinal Vein Occlusion: A Case-Control Study

ABSTRACT Purpose: The purpose of this study was to evaluate health-related quality of life in patients with retinal vein occlusion (RVO) and investigate the possible risk factors for poor quality of life in patients with RVO. Methods: Participants in the study were 67 patients with RVO, 42 male and 25 female, mean-aged 73.1 ± 10.9 years, and 70 sex- and age-matched controls. Demographic data, lifestyle factors and medical history were recorded. All patients underwent best-corrected visual acuity measurement, dilated fundoscopy and optical coherence tomography. All participants completed two questionnaires assessing quality of life (EQ-5D, NEI VFQ-25). Risk factors for health-related quality of life in RVO patients were investigated. Results: Patients with RVO exhibited significantly lower composite score for VFQ-25 compared to controls (74.1 ± 3.8 vs. 91.7 ± 3.9 for patients and controls, respectively, p < .001). In addition, RVO patients had significantly lower EQ-5D Index score compared to controls (0.88 ± 0.15 vs. 0.92 ± 0.12 for patients and controls, respectively, p = .043). Risk factors associated with quality of life in patients with RVO were found the alcohol consumption, the presence of thyroidopathy, coagulation disorders, visual acuity in the eye with RVO, central retinal thickness, the type of edema, the presence of ischemia and the condition of external limiting membrane. In multivariate analysis, only alcohol consumption and visual acuity in the eye with RVO were found to be independent risk factors, affecting quality of life in RVO patients. Conclusions: Patients with RVO presented lower quality of life in comparison with controls. Potential risk factors should be taken into account and their early detection may improve quality of life in such patients and lead to targeted health policies.

일 지역주민의 건강관련 삶의 질에 영향을 미치는 요인: 생태학적 모형(Ecological Model)의 적용

일 지역주민의 건강관련 삶의 질에 영향을 미치는 요인: 생태학적 모형(Ecological Model)의 적용

Examining Risk Factors of Health-Related Quality of Life Impairments Among Adolescents with Inflammatory Bowel Disease

Inflammatory Bowel Disease (IBD) is a chronic, costly, and burdensome disease that is typically diagnosed during adolescence. Despite the use of effective treatments, rates of relapse and intestinal inflammation remain high and put patients at risk for long term physical and psychosocial health complications. Given the costs associated with IBD, it is critical to examine potential risk factors of poor health-related quality of life (HRQoL) among patients for the enhancement and further development of interventions. As such, the aim of the current study was to examine how sociodemographic and disease characteristics, psychosocial problems, and adherence behaviors impact HRQoL among a sample of youth with IBD. 107 adolescents with IBD and their caregiver completed self- and parent-report measures as part of a psychosocial screening service. Medical records were reviewed to obtain information regarding diagnosis, insurance, medication use, illness severity, and disease activity. Results revealed lower HRQoL scores among adolescents with more psychosocial problems (Est. = -3.08; p < .001), greater disease severity (Est. = -.40; p = .001), and those who identified as Black (Est. = -.38; p < .05). Greater disease severity (Est. = .13 p = .004), use of nonpublic insurance (Est. = .32 p = .004), and fewer psychosocial problems (Est. = -.13 p = .04) were associated with greater adherence behaviors. These findings suggest that implementing individually tailored, evidence-based psychological interventions focused on coping with psychosocial problems and symptoms may be important in enhancing adherence behaviors and HRQoL among adolescents with IBD.

Health-related quality of life and associated factors in patients with myocardial infarction after returning to work: a cross-sectional study

BackgroundReturn to work following myocardial infarction (MI) represents an important indicator of recovery. However, MI can cause patients to feel pressure, loneliness and inferiority during work and even detachment from employment after returning to work, which may affect their quality of life. The aims of this study were to identify the influencing factors of Health-related quality of life (HRQoL) in patients with MI after returning to work and explore the correlations between these factors and HRQoL.MethodThis was a cross-sectional study. All participants were recruited from tertiary hospitals in China from October 2017 to March 2018. The general data questionnaire, Short-Form Health Survey-8 (SF-8), Health Promoting Lifestyle ProfileII (HPLPII), Medical Coping Modes Questionnaire (MCMQ) and Social Supporting Rating Scale (SSRS) were used to assess 326 patients with myocardial infarction returned to work after discharge. Multiple linear regression analysis was performed to explore factors related to HRQoL in patients with MI after returning to work.ResultsThe sample consisted of 326 patients. The mean total score of quality of life was 28.03 ± 2.554. According to the multiple linear regression analysis, next factors were associated with better HRQoL: younger age (B = − 0.354, P = 0.039), higher income (B = 0.513, P = 0.000), less co-morbidity (B = − 0.440, P = 0.000), the longer time taken to return to work (B = 0.235, P = 0.003), fewer stents installed (B = − 0.359, P = 0.003), participation in cardiac rehabilitation (CR) (B = − 1.777, P = 0.000), complete CR (B = − 1.409, P = 0.000), better health behaviors such as more health responsibility (B = 0.172, P = 0.000) and exercise (B = 0.165, P = 0.000), better nutrition (B = 0.178, P = 0.000) and self-realization (B = 0.165, P = 0.000), stress response (B = 0.172, P = 0.000), more social support such as more objective support (B = 0.175, P = 0.000), subjective support (B = 0.167, P = 0.000) and better utilization of social support (B = 0.189, P = 0.028), positive copping strategies such as more coping (B = 0.133, P = 0.000) and less yield (B = − 0.165, P = 0.000).ConclusionsHRQoL of MI patients after returning to work is not satisfactory. Health behavior, coping strategies, social support are factors which can affect HRQoL. A comprehensive and targeted guide may be a way to improve HRQoL and to assist patients’ successful return to society.

Individual, Social, and Societal Correlates of Health-Related Quality of Life Among African American Survivors of Ovarian Cancer: Results from the African American Cancer Epidemiology Study.

While the incidence of epithelial ovarian cancer (EOC) is lower among African American (AA) women compared with European American (EA) women, AA women have markedly worse outcomes. In this study, we describe individual, social, and societal factors in health-related quality of life (HRQL) in AA women diagnosed with EOC in the African American Cancer Epidemiology Study (AACES) that we hypothesize may influence a patient's capacity to psychosocially adjust to a diagnosis of cancer. There were 215 invasive EOC cases included in the analysis. HRQL was measured using the SF-8 component scores for physical (PCS) and mental (MCS) health. We used least squares regression to test the effects of individual dispositional factors (optimism and trait anxiety); social level (perceived social support); and societal-level factors (SES defined as low family income and low educational attainment, and perceived discrimination) on HRQL, while adjusting for patient age, tumor stage, body mass index, and comorbidity. Mediation analysis was applied to test whether social support and physical activity buffer impacts of EOC on HRQL. Optimism, trait anxiety, social support, poverty, and past perceived discrimination were significantly associated with HRQL following diagnosis of EOC. Specifically, higher family income, lower phobic anxiety, and higher social support were associated with better wellbeing on the MCS and PCS (p < 0.01). Higher perceived discrimination was associated with both lower MCS and PCS, whereas higher optimism was associated with higher MCS. Physical activity (MET-min/week) and social support displayed significant overall mediation for effects of SES on MCS and PCS, but not for trait anxiety. Both pre- and postdiagnosis characteristics of AA women with EOC are important predictors of HRQL after cancer diagnosis. Individual, social, and societal-level factors each contribute to HRQL status with EOC and should be assessed.

Research on Influence of Clopidogrel on Life Quality in Patients with Transient Ischemic Attack and its Influencing Factors

Purpose: To analyze the basic situation and health related quality of life (HRQOL) results of patients with transient ischemic attack (TIA), and to study the influencing factors of health related quality of life in patients receiving clopidogrel. Method: Divide the TIA patients into clopidogrel group, aspirin group and untreated group. Measure HRQOL scores of TIA patients using the short form 36 questionnaire (SF-36) scale and analyze influencing factors of HRQOL with one-way ANOVA and multivariate stepwise linear regression statistical methods. Results: The differences of HRQOL scores among three groups are of statistical significance (F = 4.29, P = 0.00). There is no difference in HRQOL score between clopidogrel group and aspirin group (t = 5.35, P = 0.00), but HRQOL scores of clopidogrel group and aspirin group are higher than those of the untreated group (t = 6.14, P = 0.00; t = 5.16, P = 0.00). The HRQOL scores of clopidogrel group are positively correlated with diet, exercise, gender and family harmony (P &lt; 0.05), but negatively correlated with diabetes, hypertension, smoking, drinking, hyperlipidemia, age, career and ABCD2 score (P &lt; 0.05). Conclusion: TIA patients who received secondary prevention with clopidogrel and aspirin show better life quality results than those who did not. There were many factors influencing clopidogrel's treatment effect. Paying attention to middle-aged and elderly, the obese, mental workers and female TIA patients, teach TIA patients to quit smoking, drinking and eating low-salt and low-fat food, actively treating their hypertension, hyperlipidemia and diabetes and laying emphasis on psychological counseling and exercise can significantly improve the treatment effect of clopidogrel.

A study on oral health-related quality of life in end-stage renal disease patients undergoing hemodialysis

Objective To investigate oral health-related quality of Life (OHRQoL) in end-stage renal disease Patients undergoing hemodialysis(HD) and its influencing factors. Methods Through convenient sampling, totally 185 HD patients in two first-class tertiary hospitals in Changchun were investigated with the Oral Health Impact Profile-14(OHIP-14). Influencing factors of oral health-related quality of life of patients were extracted from patients’general information and oral health behavior questionnaire. Single factor analysis and multivariate linear stepwise regression analysis were used for statistical analysis. Results The scores of oral health-related quality of life in hemodialysis patients were Significantly higher than those of the normal population in China (P<0.05) and age, duration of hemodialysis, status of smoking, frequency of brushing, brush teeth time, status of using mouth wash, and frequency of oral examination were influencing factors for oral health-related quality of life of HD patients, (β=-0.156-0.164, all P<0.05) . Conclusions Oral health-related quality of life in HD patients is poor. Medical workers should pay attention to older patients with longer duration of hemodialysis and poor oral health behavior, take effective interventions to improve oral health-related quality of life of HD patients. Key words: Renal dialysis; Oral health-related quality of life; Influencing factor

The Influence from Sense of Coherence on Perceived Health after Prostatectomy A 5 Year Follow Up

The purpose of the study was to to describe which factors of health related quality of life were associated with a high sense of coherence in a 5 year perspective. The sense of coherence, SOC-scale, EORTC QLQ C-30 and PR 25 questionnaires were applied to a sample of 222 men at baseline and over 5 years following radical prostatectomy. Result showed significant association to SOC in psychological aspects (emotional and cognitive functioning, p=&lt;0.00-0.04 respectively 0.04) and for hormone treatment related symptoms (i.e. manhood p=&lt;0.05). High SOC was associated with quality of life (index) in the early post treatment period and to aspects of general functioning (role-, emotional- respectively cognitive) in year 3 and 5. High sense of coherence was interpreted to be a health resource for experiencing life quality connected to different aspects at different time points of the data collection. The result showed stability in SOC and QoL scoring over 5 years.

Influencing Factors of Health-related Quality of Life:An Analysis Based on the National Health Services Survey in Jilin Province,2013.

Objective To understand the health-related quality of life (HRQoL) and its influencing factors in Jilin province and compare two life quality measurement methods. Methods The data of 13 700 people aged above 15 years in Jilin province were extracted from the National Health Services Survey 2013. Self-rated health scores and EuroQol 5-dimension utility values were used to evaluate the HRQoL. Multivariable linear regression model was used to analyze the influencing factors. Results The self-rated health score was 81.26±15.73 in Jilin province,while utility values of health status were 0.959±0.124. The influencing factors of HRQoL included age,residency,education,income,type of health insurance,having non-communicable chronic disease and having disease in last two weeks. The age under 45,income,having non-communicable chronic disease,and having disease in last two weeks had stronger effect on self-rated health,whereas residency and type of health insurance had more effect on utility values of health status. Conclusion People in Jilin province have good quality of life. Both methods have their advantages and weakness. It is important to choose the right evaluation method depended on the objective of a specific study.

Level and influencing factor of oral health-related quality of life among 280 patients with chronic periodontal disease

Objective To investigate the level and influencing factors of oral health-related quality of life in patients with chronic periodontal disease. Methods 280 patients with chronic periodontal disease were investigated, using Pearson, Spearman correlation and multivariate linear regression to identify influencing factors of oral health-related quality of life. Results The oral health impact profile was in the middle level with a total score of 16.93±7.37. The influencing factors were self-efficacy for self-care, dental fear and entering into supportive periodontal therapy, which contributed 24.0% of the variance. Conclusions The oral health-related quality of life in patients with chronic periodontal disease is in low level. In order to improve the oral health-related quality of life in patients with chronic periodontal disease, health care providers should strengthen patients′ self-efficacy and reduce the patients′ dental fear. Key words: Chronic periodontal; Quality of life; Influencing factors

Comparison of beta-binomial regression model approaches to analyze health-related quality of life data.

Health-related quality of life has become an increasingly important indicator of health status in clinical trials and epidemiological research. Moreover, the study of the relationship of health-related quality of life with patients and disease characteristics has become one of the primary aims of many health-related quality of life studies. Health-related quality of life scores are usually assumed to be distributed as binomial random variables and often highly skewed. The use of the beta-binomial distribution in the regression context has been proposed to model such data; however, the beta-binomial regression has been performed by means of two different approaches in the literature: (i) beta-binomial distribution with a logistic link; and (ii) hierarchical generalized linear models. None of the existing literature in the analysis of health-related quality of life survey data has performed a comparison of both approaches in terms of adequacy and regression parameter interpretation context. This paper is motivated by the analysis of a real data application of health-related quality of life outcomes in patients with Chronic Obstructive Pulmonary Disease, where the use of both approaches yields to contradictory results in terms of covariate effects significance and consequently the interpretation of the most relevant factors in health-related quality of life. We present an explanation of the results in both methodologies through a simulation study and address the need to apply the proper approach in the analysis of health-related quality of life survey data for practitioners, providing an R package.

Association of obesity and health related quality of life in Iranian children and adolescents: the Weight Disorders Survey of the CASPIAN-IV study.

Considering the role of different ethnical, cultural and geographical factors in health related quality of life (HRQOL) as well as the perception of different populations regarding various weight disorders, we aimed to evaluate the association between body mass index (BMI) and HRQOL in Iranian children and adolescents. This cross-sectional study was part of the Weight Disorders Survey of the CASPIAN-IV study. During this study, students aged 6-18 years from urban and rural areas of 30 provinces of Iran were selected. HRQOL of the students was evaluated by using the Persian version of the Pediatric Quality of Life inventory (PedsQL™ 4.0™ 4.0) Generic Core Scales. The mean of total HRQOL and its subscales were compared in underweight, normal weight, overweight and obese students. The mean of total HRQOL, physical functioning and psychological functioning scores in the total population were 83.31, 84.25 and 82.79, respectively. The mean of the total HRQOL score and the psychosocial score were significantly lower in underweight students aged 6-12 years than in other groups (p<0.05). The mean of the total HRQOL score and psychosocial score were significantly lower in obese students aged 13-18 years than in other groups (p<0.05). Overweight and obesity was negatively associated with total HRQOL, psychosocial and school functioning subscales (p<0.05). There was a significant negative association between emotional functioning and obesity (p<0.05). The findings or this study support the importance of personal perception and cultural norm roles in HRQOL. Given the association between weight disorders and psychosocial health, it is suggested that social and cultural factors have a more crucial role in the HRQOL of children and adolescents.

Clinico-epidemiological factors of health related quality of life among people with type 2 diabetes.

AIMTo investigate the quality of life (QOL) and its clinical and epidemiological correlates among people with type 2 diabetes.METHODSThis cross-sectional study was conducted in Tabriz, Northwest of Iran, including a total of 394 people with type 2 diabetes using convenient sampling method from November 2014 to March 2015. General information including demographic, socioeconomic status and lifestyle factors were collected by trained interviewers. Clinical information was retrieved from clinic’s record and QOL was assessed using the 26-item WHOQOL-BRIFE questionnaire. Univariate and multivariate linear regression were performed to assess the related factors and QOL dimensions.RESULTSThe mean of overall health related QOL was 52.11 ± 11.53 and the maximum and minimum dimensions were respectively seen in psychological (60.38 ± 14.54) and social (38.32 ± 16.94) dimensions. The results of multiple linear regression showed a significant overall relationship between HRQOL and age (b = -1.48%, 95%CI: -0.03 and -2.93) level of education (b = 4.12%, 95%CI: 2.73 and 5.5), number of comorbidities (b = -2.41%, 95%CI: -3.89 and -9.41), and level of income (b = 1.98, 95%CI: 0.05 and 3.9), functional limitation (b = -3.59, 95%CI: -2.26 and -4.92) and psychological distress (b = -2.02%, 95%CI: -2.83 and -1.21). Level of education, functional limitation, psychological distress were associated with the score of physical, mental and environmental dimensions, and number of comorbidities was associated with the score of physical and mental dimensions.CONCLUSIONBased on our findings, lifestyle modification and increasing facilities of clinics providing service can be effective steps to improve the QOL among people with type 2 diabetes.

Predictive factors for Health-related Quality of Life in Congestive Heart Failure: systematic review

Predictive factors for Health-related Quality of Life in Congestive Heart Failure: systematic review

Calidad de vida relacionada con la salud de los pacientes con insuficiencia cardiaca crónica sistólica en España: resultados del estudio VIDA-IC

Introduction and objectivesAlthough heart failure negatively affects the health-related quality of life of Spanish patients there is little information on the clinical factors associated with this issue. MethodsCross-sectional multicenter study of health-related quality of life. A specific questionnaire (Kansas City Cardiomyopathy Questionnaire) and a generic questionnaire (EuroQoL-5D) were administered to 1037 consecutive outpatients with systolic heart failure. ResultsMost patients with poor quality of life had a worse prognosis and increased severity of heart failure. Mobility was more limited and rates of pain/discomfort and anxiety/depression were higher in the study patients than in the general population and patients with other chronic conditions. The scores on both questionnaires were very highly correlated (Pearson r =0.815; P < .001). Multivariable linear regression showed that being older (standardized β=-0.2; P=.03), female (standardized β=-10.3; P < .001), having worse functional class (standardized β=-20.4; P < .001), a higher Charlson comorbidity index (standardized β=-1.2; P=0.005), and recent hospitalization for heart failure (standardized β=6.28; P=.006) were independent predictors of worse health-related quality of life. ConclusionsPatients with heart failure have worse quality of life than the general Spanish population and patients with other chronic diseases. Female sex, being older, comorbidity, advanced symptoms, and recent hospitalization are determinant factors in health-related quality of life in these patients.Full English text available from:www.revespcardiol.org/en

Health-related Quality of Life of Patients With Chronic Systolic Heart Failure in Spain: Results of the VIDA-IC Study

Introduction and objectivesAlthough heart failure negatively affects the health-related quality of life of Spanish patients there is little information on the clinical factors associated with this issue. MethodsCross-sectional multicenter study of health-related quality of life. A specific questionnaire (Kansas City Cardiomyopathy Questionnaire) and a generic questionnaire (EuroQoL-5D) were administered to 1037 consecutive outpatients with systolic heart failure. ResultsMost patients with poor quality of life had a worse prognosis and increased severity of heart failure. Mobility was more limited and rates of pain/discomfort and anxiety/depression were higher in the study patients than in the general population and patients with other chronic conditions. The scores on both questionnaires were very highly correlated (Pearson r =0.815; P < .001). Multivariable linear regression showed that being older (standardized β=-0.2; P=.03), female (standardized β=-10.3; P < .001), having worse functional class (standardized β=-20.4; P < .001), a higher Charlson comorbidity index (standardized β=-1.2; P=.005), and recent hospitalization for heart failure (standardized β=6.28; P=.006) were independent predictors of worse health-related quality of life. ConclusionsPatients with heart failure have worse quality of life than the general Spanish population and patients with other chronic diseases. Female sex, being older, comorbidity, advanced symptoms, and recent hospitalization are determinant factors in health-related quality of life in these patients.

Predicting Factors for Health related Quality of Life among Older Adults at Senior Centers in Korea

Purpose: The purpose was to identify factors affecting health related quality of life among older adults in Korea. Methods: Participants were 334 people, 60 or over, and registered at senior centers. Health related quality of life was measured using EuroQol 5-Dimension Questionnaire (EQ-5D). Results: Order of frequency for EQ-5D was pain/discomfort, mobility, anxiety/depression, usual activity, and self-care. Of the participants, 27.5% reported no problem in any of the dimensions of EQ-5D. Mean score for the EQ-5D was 0.82±0.14, and EQ-VAS (Visual Analog Scale), 60.26±22.28. Socio-demographic factors (age, gender, education, spouse) and health factors (self-rated health status, symptom experience, IADL, depression, waist circumference, and regular exercise) explained 43% of variance in health related quality of life using EQ-5D, whereas they explained 34% variance in health related quality of life using EQ-VAS. Symptom experience was the most significant factor affecting health related quality of life according to EQ-5D, and depression, for health related quality of life according to EQ-VAS. Conclusion: Finding indicate that to increase elders' health related quality of life as measured by the EQ-5D, staff at senior centers should pay attention to older adults when they have more experiences of symptoms and when they are depressed.

A prospective longitudinal evaluation and affecting factors of health related quality of life after appendectomy

BackgroundThe aim of the present study was to longitudinally evaluate the pattern of Health-Related Quality of Life (HRQoL) alterations, as an indirect convalescence index after appendectomy, to assess the timing of its restoration to the healthy population levels and to attempt a profound investigation into factors determining HRQoL outcomes. MethodsUncomplicated cases of histologically verified acute appendicitis (AA) were enrolled in a prospective cohort study. HRQoL indices were collected at baseline, 15 days, 1 and 3 months using EQ-5D, SF-36 and, GIQLI questionnaires. Data were processed with non-parametric tests and logistic regression analysis. ResultsFor the 147 patients eventually included, significant improvements compared to baseline at EQ-5D and SF-36 general health and physical function domains were noted at 15 days, while bodily pain was worse. The majority HRQoL parameters were significantly better at the 1st and the 3rd-month compared to baseline and the 15th-day assessments. General health, physical and emotional function were restored at the general population levels between 15 days and 1 month, while bodily pain, social function and EQ-5D indices between the 1st and 3rd month. Logistic regression analysis indicated that high Alvarado score was the most powerful predictor of HRQoL impairment with older age coming second. ConclusionsPost-appendectomy HRQoL disturbances predominate and the burden of AA should not be underestimated. Convalescence period as translated by HRQoL restoration may be extended beyond the second week and up to the first month. Degree of inflammation and patient's age emerged as key mediators of HRQoL outcomes.

도시와 농촌 경로당 이용 노인의 건강관련 삶의 질 영향요인 비교 연구

Abstract Purpose: The purpose of this study was to compare urban-rural differences on influencing factors of health related quality of life(HRQoL) of the elderly in senior center. Methods: The subjects were 902 older adults (571 from urban areas, 331 from rural areas). Data were collected using a questionnaire from 20 July to 31 August, 2011. The SPSS/WIN program was used for data analysis. Results: For older adults of urban areas, the influencing factors of HRQoL were depression, age, subjective health, drinking, number of chronic disease, and smoking. On the other hand, the influencing factors of HRQoL of older adults of rural areas were depression, subjective health, number of chronic disease, and educational level. The significant factors of HRQoL were depression, subjective, and number of chronic disease in both urban and rural areas. Conclusion: Public health nurses should consider urban-rural differences when designing HRQoL enhancing program for the elderly in senior center. Key Words :