Objectives: Thalassemia is the most common genetic disorder globally. In Afghanistan, the epidemiology and clinical characteristics of the disease are not studied officially. This study aims to explore the epidemiological pattern and clinical profile of thalassemia patients registered in the National Blood Bank (NBB), Kabul, Afghanistan. Material and Methods: A retrospective medical record review was conducted to analyze registries and conduct phone calls for follow-up patients registered in the NBB during 2019–2020 in Kabul. The confirmed case was any patient tested for fetal hemoglobin and blood film. Data were collected using a form matching the patient’s registers. Epi Info v.7 was used for data management and descriptive measures analysis. Results: Totally 411 patients with thalassemia were enrolled in the analysis. Out of all patients, 225 (54.61%) were male, with an overall mean age of 6.89 (±4.06) years. The highest proportion of patients was clustered around age groups of 2–8 years (56%). Pashtuns’ ethnicity had the highest percentage of patients (63%) and Hazara the lowest (1%). Almost the majority of cases under management were thalassemia major (98.8%), and just one case was recorded as intermedia and four cases as minor. According to laboratory tests, 88 (21.4%) were positive for hepatitis C, 2 (0.5%) positive for hepatitis B, and 1 (0.2%) for human immunodeficiency virus. As a whole, 251 (61.67%) had a type of consanguinity marriage. In patients, the blood groups of A+ (27%), B+ (27%), and O+ (25%) were almost equally distributed, while AB+ (10%), O negative (4%), A negative (2%), and AB negative (0.2%) had low proportions. The residency of the majority (87.13%) was Kabul. Totally, 18 (4.36%) had surgical operations, and 11.8% reported children died due to thalassemia. Conclusion: Thalassemias are common in Afghanistan, and facility for management is lacking. Consanguineous marriage was more common and probably a contributing factor to disease. The establishment of more centers and a full review of factors are recommended.
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