Facial Eczema Research Articles

Ocular surface disease in moderate-to-severe atopic dermatitis patients and the effect of biological therapy.

Atopic dermatitis (AD) is a chronic inflammatory skin disease for which new targeted therapies are currently available. Due to the increased rates of ocular surface disease (OSD) reported during treatment with these new targeted treatments, more insight into the occurrence and pathomechanism of OSD in moderate-to-severe AD patients is needed. Therefore, this review's first part highlights that most patients with moderate-to-severe AD already have characteristics of OSD before starting targeted treatment. Remarkably, not all AD patients with OSD report ocular symptoms. OSD in AD is associated with less conjunctival goblet cells (GC) compared to healthy controls. In addition, OSD severity in AD patients is associated with high AD activity, the presence of eyelid and/or facial eczema, and high levels of AD-related severity biomarkers in tear fluid. The second part of this review highlights that pre-existing ocular pathology (e.g. in combination with the use of ophthalmic medication or eyelid eczema) may be associated with the development of dupilumab-associated ocular surface disease (DAOSD). During dupilumab treatment, DAOSD (which can be new-onset OSD or worsening of pre-existing OSD) is observed in approximately one-third of the dupilumab-treated AD patients. Anti-inflammatory ophthalmic treatment improves DAOSD, and dose reduction of dupilumab may also be an effective treatment option. The pathomechanism of DAOSD is still not fully elucidated. In a prospective study low, but stable conjunctival GC numbers were observed in moderate-to-severe AD patients, before and during dupilumab treatment. However, the Mucin 5 AC (MUC5AC) expression of GCs decreased during dupilumab treatment, suggesting an impairment of the GC function by dupilumab treatment. In addition, higher dupilumab tear fluid levels were found in dupilumab-treated AD patients with moderate-to-severe OSD compared to patients with no or mild OSD, whereas the dupilumab serum levels are similar. Clinicians should be aware of the frequent occurrence of OSD in moderate-to-severe AD patients, and a low-threshold referral to an ophthalmologist is recommended.

Fungi, including Pithomyces chartarum cause facial eczema and inflammation in grazing sheep in Western China

Facial eczema is often found in flocks of grazing sheep in China. To investigate fungi species those cause disease and pathological roles. Forage and soil samples were collected during the pathogenic season and cultured. Samples were collected from regions with and without facial eczema affected sheep. Fungal isolation and identification, statistical analysis of fungal species and distribution were performed. Pathological changes, biochemical parameters of serum liver function and protection of inflammatory factors that tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-12 (IL-12) were observed. Fungal cultivation and identification showed that separation rate of Alternaria, Pithomyces chartarum, Fusarium and Aspergillus were higher, particularly, Pithomyces chartarum was significantly identical. Pathological anatomy and histology indicated that the disease likely attacked merino ewes with the age of 6 months old. The clinical manifestations were characterized by inflammational edema in face (ears and eyelids) and mandibular area. Postmortem examination of dead lambs showed enlargement of liver with yellow white patchs of necrotic lesion and tuberous sclerosis and fibrosis on section. Histologic examination of liver showed extravasated blood, severe lesion of liver cells and bile duct, and fatty degeneration. In sheep, fungal toxin induced the secretion of TNF-α, IL-6 and IL-12. These results revealed that Pithomyces chartarum maybe caused facial eczema and inflammation in sheep. The facial eczema was allergic eczema caused by hepatic dysfunction and hepatonecrosis.

Predicting facial eczema risks in a changing New Zealand climate

Facial eczema is a major concern for New Zealand farmers due to its economic impact and animal welfare implications. The disease occurs when animals ingest sporidesmin, a mycotoxin produced by spores of the fungus Pseudopithomyces chartarum. Spore production is related to weather conditions; thus the incidence and severity of facial eczema varies between years, with thedisease commonly occurring from late summer through autumn in the North Island. We developed a simple model to estimate climatic suitability for P. chartarum sporulation and ran it using climate data for 2008-2021 to compare its estimates with spore counts from the same years. Model climatic suitability estimates had significant linear correlations with an index of exposure to spores derived from spore counts at both national and local scales. Model results were also consistent with a documented outbreak of facial eczema. Using predicted future climate data from the Hadley Centre Global Environment Model version 2 and two emissionsscenarios, the model suggested climatic suitability for P. chartarum sporulation will increase with time in many New Zealand regions, particularly in the southern North Island and eastern parts of the South Island. However, it could remain relatively static in some other areas, thus the degree of change in climatic suitability for P. chartarum sporulation is predicted to vary between New Zealand regions.

Farmer wellbeing and animal welfare: Exploring the connections using the case of facial eczema

While a relationship between animal welfare and farmer wellbeing is reasonably well documented, there is a lack of clarity about the various ways animal diseases affect this relationship and whether common disease (i.e. recurrent or seasonal) or novel outbreaks have different impacts. Facial eczema (FE) is an animal disease that affects ruminants and camelids and can lead to loss of productivity, illness and death of the animal. FE has elements of both common and novel outbreaks and, based on semi-structured interviews with 14 farmers and rural advisors, we have identified three ways FE affects farmers. The first is anticipatory anxiety often talked about by farmers in areas where FE is almost inevitable. Second, helplessness was experienced by farmers who experienced FE as a novel, unexpected outbreak and who lacked resources and skills to mitigate its effects. Third, farmers whose experience with FE was sporadic spoke of mis-managing a preventable disease, leading to guilt and self-doubt. We conclude that because animal welfare and farmer wellbeing are related, addressing both common and novel animal disease is an essential part of agricultural support. Support can also be improved by recognising recurrent and novel outbreaks may have different impacts, each of which may require distinctly different measures.

Facial eczema in animals

Facial eczema in animals

The Correlation Between Wearing Face Masks and Skin Damage in Adults During the COVID-19 Pandemic: A Cross-Sectional Study in Jeddah, Saudi Arabia.

Background The impact of COVID-19 on the world is rapidly spreading among countries. According to WHO, wearingface masks was recommended to prevent its spread. After regularuse of face masks, some people have experienced common skin disorders such as facial acne, rash, and eczema. This paper aims to cite the prevalence and potential risk of wearing a face mask on the skin by exploring some of the rationales that have been established in the literature. Methodology A cross-sectional study was carried out in Jeddah, Saudi Arabia in November 2021. A self-administered online questionnaire was distributed among 389 participants from the adult public to find the correlation between face mask wearing and skin damage during the COVID-19 pandemic. Statistical analysis was conducted using the IBM SPSS statics for windows, version 25.0(IBM Corp., Armonk, USA) to evaluate and test the hypothesis. Results The study included 389 participants; 63.8% of them were female and 36.2% were male. The main resultof this study was that there was a statistically significant association between the duration and frequency of wearing a face mask and developing skin damage. 58.1% of the participants were using face masks for more than 4 hours. Furthermore, 22% and 59.1% of the male and female participants, respectively, said they noticed adverse skin reactions on their faces after using a face mask. Conclusion Our study revealed that 46% of the participants noticed adverse skin reactions on the face by wearing a face mask. Females had a significantly higher chance of developing skin irritation than males.

Comparison of a novel form of zinc with zinc oxide bolus licensed for prevention of facial eczema, and interaction with copper oxide in sheep.

To evaluate a novel elemental zinc bolus compared with a registered positive control zinc oxide bolus and assess serum zinc concentrations following concomitant treatment with a capsule containing copper oxide needles. Forty Romney-cross ewes were randomly allocated in a 2 × 2 factorial design study. On Day 0, 20 ewes received novel boluses containing elemental zinc (Investigational Veterinary Product, IVP) while 20 received a zinc oxide bolus (control; CP). Half the animals in each zinc treatment group (n=10) were treated with a copper oxide needle capsule [Copasure® - Ewe]. Weekly, from Day -7 to 56, all ewes were assessed for signs of photosensitization, and for 10 ewes from each zinc treatment groups, samples were collected for analysis of serum GGT activity, serum zinc concentrations, faecal zinc concentrations and on Days -7 and 56, liver copper concentrations. Multivariable random-effects models assessed the effects of zinc treatment, copper treatment, treatment interactions and time on all analytes. Regression models examined associations between serum and faecal zinc concentrations and GGT activity. Low spore numbers indicated low Pithomyces chartarum challenge. Serum zinc levels were significantly higher in the IVP than in the CP group [p < 0.0001] and varied by time [p < 0.001] and positively associated with faecal zinc concentration [p < 0.001]. Copper treatment did not affect serum zinc [p=0.82] or faecal zinc [p=0.92] concentrations. Liver copper concentrations did not differ between zinc treatment groups on Day -7 [p=0.6] or Day 56 [p=0.95]. Only the CP/no copper group had no increase in liver copper concentrations.

Why Does Facial Eczema Differ From Body Eczema?

The pathophysiology of atopic dermatitis (AD) is multifactorial, influenced by genetics, skin barrier dysfunction, and environmental stressors. There is a lack of research comparing the etiologies and pathologic mechanisms accounting for differences in facial vs body eczema. To explore reasons why facial eczema may differ from body eczema. There are key differences in the environments of the face and body that may lead to AD exacerbation. These include differences in the skin microbiome, sebaceous glands concentration, and levels of natural moisturizing factor. The face is exposed to more environmental stress compared with the rest of the body. These stresses include aeroallergens, ultraviolet radiation, and cosmetic products. Management of facial eczema also differs from that of body eczema due to the avoidance of high potency topical steroids on the face. Topical steroids increase microbiome diversity, and lack of topical steroid use on the face can lead to decreased microbiome diversity and increased AD severity. Facial and body eczema differ due to differences seen in anatomical structure and environmental exposures. These differences should be further researched and used in the management of facial vs body eczema and can also be used in the development of new AD treatments. J Drugs Dermatol. 2022;21(10): 1119-1123. doi:10.36849/JDD.6354.

Chronic pithomycotoxicosis associated with obstructive rhinopathy in sheep

Pithomycotoxicosis (facial eczema) is a seasonal hepatogenous photosensitization of sheep caused by the ingestion of sporidesmin contained in the spores of the fungus Pithomyces chartarum. We describe 4 cases of obstructive rhinopathy associated with chronic pithomycotoxicosis naturally occurring in the north of Spain. Sheep were 5 to 7 years old and Latxa breed. A detailed clinical study was conducted together with computerized tomography examination and completed by necropsy and histopathology. All sheep developed a permanent narrowing of the nasal lumen close to the nostrils causing inspiratory dyspnea and snoring. Computerized tomography demonstrated a significant increase of soft tissue in the rostral nasal cavity. Elevated gamma-glutamyl transferase, alanine aminotransferase, and lipase were noted on serum biochemistry. At necropsy, liver atrophy and fibrosis associated with chronic pithomycotoxicosis was identified in 3 of the sheep. All sheep had whitish elevations and rough surfaces on the alar folds and areas adjacent to the nasal surfaces. Histopathologic assessments, which included histochemical and immunohistochemical techniques, of the nasal lesions identified moderate to severe arteriosclerosis in 21.5% to 61.9% of the small arteries evaluated with surrounding fibrosis and edema. No changes associated with hypersensitivity reactions were found. These lesions were similar to the ones described in blood vessels of the liver in chronic pithomycotoxicosis and in our cases. The results of this study suggest a direct action of the sporidesmin on the rostral nasal cavity. Further studies are needed to analyze the impact of the sporidesmin on the sheep nasal mucosa.

Assessing effectiveness and comfortability of a two-layer cloth mask with a high-efficiency particulate air (HEPA) insert to mitigate COVID-19 transmission

A face mask is essential personal protective equipment to mitigate the spread of COVID-19. While a cloth mask has the least ability to prevent the passage of infectious respiratory droplets through it compared to surgical and N95 masks, the surgical mask does not fit snugly and causes significant air leakage. The synthetic fibers in the latter reduce comfortability and are an allergen for facial eczema. Moreover, the N95 mask causes CO2 inhalation and reduces heat transfer in the nose. Therefore, the objective of the present work is to improve the effectiveness of a two-layer cloth mask by introducing an intermediate, high-efficiency particulate air (HEPA) filter layer. A significant volume of impacted droplets penetrates through a single-layer cloth mask, ejecting secondary droplets from the rear side. However, a two-layer cloth mask prevents this ejection. Despite slowing down the liquid penetration, capillary imbibition through cloth due to its hydrophilicity causes the transport of the liquid into the second layer, resulting in a thin-liquid layer at the mask's rear-side surface and contaminating it. Conversely, the HEPA filter inserted in the cloth mask prevents the imbibition, making the second cloth layer free of contamination. We attribute the impedance to the imbibition by the intermediate HEPA filter layer to its hydrophobic characteristics. We experimentally and analytically assess the role of wettability on capillary imbibition. The breathability measurements of masks show that the HEPA inserted in the cloth mask does not reduce its breathability compared to that of the surgical mask.

Facial dermatoses and use of protective mask during Covid-19 pandemic: A clinical and psychological evaluation in patients affected by moderate-severe atopic dermatitis under treatment with dupilumab.

During the SARS‐COV‐2 pandemic, using face masks became mandatory in many countries. Although evidence suggests that masks can exacerbate several inflammatory skin diseases, few studies focus on their real impact on eczema localized to the face in atopic dermatitis (AD) patients. The aim of this study is to evaluate facial eczema prevalence during pandemic and its psychological impact in AD patients pre‐assessed for systemic treatment and/or in therapy with dupilumab. This study includes 71 patients affected by moderate–severe AD, treated with dupilumab at SCDU of Dermatology in Novara, Italy. We calculated the number of subjects with facial involvement in pre‐ and post‐pandemic periods and the related localization trend. We evaluated, in the two groups, clinical and psychological indicators recorded at each visit and the score modifications during the observational period. No statistically significant differences were observed in facial eczema prevalence, between pre‐ and post‐pandemic periods (p = 0.7618) and in facial eczema remission among the two groups (p = 0.1903). In post‐pandemic period, psychological scores were significantly lower (DLQI and HADS respectively with p < 0.0001 and p = 0.0025) and the reduction in EASI score during observational period was significantly greater (p = 0.0001). Our analysis revealed a potential protective effect of masks on face eczema, suggesting that they could enhance dupilumab efficacy. Face masks, covering sensitive areas, can positively contribute to mental distress in patients with facial eczema, and being associated with a lower allergic diseases incidence may sustain dupilumab in reducing AD severity.

Longitudinal prevalence of atopic dermatitis among freshmen at Hiroshima University between 2002 and 2019.

The prevalence of atopic dermatitis (AD) has been steadily increasing in recent decades, reaching a steady plateau at the end of the 20th century. However, most of them were surveys of children, and the current prevalence and severity of AD in adults are unknown. A longitudinal survey including 40 649 freshmen attending Hiroshima University between 2002 and 2019 was conducted, with the aim to determine changes in AD prevalence in young adults over the age of 18years. All data were longitudinally collected at a fixed time of the year. The AD diagnosis and severity assessment were made by dermatologists based on the diagnostic criteria in the Japanese Guidelines for AD. History or comorbidities of asthma and allergic rhinitis/conjunctivitis, current AD management, and use of topical corticosteroids (TCS) were also surveyed using a questionnaire. The prevalence of AD in university freshmen is slightly increasing from 9.1% in 2002 to 12.0% in 2010, remaining steady at around 10-11% until 2019, with poorly controlled AD present in nearly 10%. History or comorbidities of asthma and allergic rhinitis/conjunctivitis slightly increased from 2006 to 2019 in both the students with and without AD. Facial eczema was common among those with severe and most severe AD, whereas approximately 50% of the students with moderate AD and approximately 20% of those with mild AD exhibited facial eczema. The percentage of students treating AD at medical institutions and those self-managing was almost the same. This survey also revealed the presence of substantial anxiety regarding TCS use for AD and the necessity of promoting more effective explanation and education on AD by medical professionals.

Occupational contact dermatitis among young people in Denmark - A survey of causes and long-term consequences.

Studies on the causes and consequences of occupational contact dermatitis (OCD) among young workers are non-existent. Determine causes and consequences of OCD among workers younger than 35 years of age. A questionnaire was sent to 6251 workers younger than 35 years at notification with recognized OCD (response rate 47%). The most prevalent occupations were health care workers, kitchen workers, nursery teachers, and hairdressers and beauticians. Seventy-six percent still had eczema, and 77% of these had eczema half to all the time over the last 3 months, with 61% evaluating their eczema as moderate to very severe. Fifty-three percent had changed their occupation since notification, and 42.5% had lost their job because of OCD. Allergic OCD increased the odds ratio (OR) for facial or foot eczema, job loss, change in work tasks, difficulties finding work, decrease in income, and sick leave. Age at notification of 25 years of age or younger increased the risk of job loss and feeling restricted in choice of job. Workers in the food industry had a higher OR for job loss, whereas hairdressers and beauticians had a higher risk of job loss and a decrease in income. The severe, long-term consequences of OCD notification signify the need for further preventive strategies among young workers.

First case of pithomycotoxicosis in sheep in the Netherlands

AbstractPithomycotoxicosis, commonly known as facial eczema, is a hepatogenous photosensitisation in grazing ruminants caused by intake of sporidesmin‐containing spores of the saprophytic fungus Pithomyces chartarum. Although this is a significant sheep disease in various countries in the world, it is rarely seen in Europe, and has been reported only once in the Netherlands, but in cattle. In October 2019, both sheep and lambs in a flock of 50 breeding sheep showed clinical signs of photosensitisation, including oedematous facial swelling, reddening of eyelids, ulcerative skin lesions, hyperpigmentation, and in some cases icteric sclerae. The combination of clinical signs, seriously elevated glutamate dehydrogenase, gamma‐glutamyl transferase and total bilirubin, necropsy findings, course of events, time of the year, absence of known toxic plants or mycotoxins, strongly suggest that sporidesmin was the most probable cause of this case of hepatogenous photosensitisation, which makes this the first reported case of pithomycotoxicosis in sheep in the Netherlands.

Diagnosing subclinical facial eczema in cattle: does combining liver enzyme tests increase the accuracy of diagnosis?

ABSTRACT Aims To assess whether adding glutamate dehydrogenase (GDH) activity measurements to measurements of gamma-glutamyl transferase (GGT) activity appreciably increases the accuracy of diagnosis of subclinical facial eczema (FE) in cattle. Methods As part of a larger study on the impact of FE on productivity, GGT and GDH activities were measured in serum samples collected from 426 cattle from one dairy farm in the Taranaki region in April 2018. Bayesian latent class analysis was then used to estimate herd prevalence of subclinical FE as well as the specificity and sensitivity of the activity in serum of GGT or GDH alone, and of GGT and GDH activities combined, as diagnostic tests for subclinical FE. Results The latent class analysis estimated the true prevalence of subclinical FE in the study population as 47.5 (95% probability interval (PI) = 38.3–55.3)%. There was no evidence of any clinically relevant difference between GGT and GDH activities as predictors of subclinical FE; the difference between the areas under the receiver operating characteristic curves for the two measures was 0.005 (95% PI = –0.02 to –0.03). Using the two tests in parallel, with a threshold of 50 IU/L for GGT and 225 IU/L for GDH resulted in specificity and sensitivity of >95%, markedly increasing the accuracy of diagnosis of subclinical FE compared to using GGT or GDH alone at any threshold Conclusions and clinical relevance In this herd, combining the two tests resulted in a clinically relevant improvement in the accuracy of diagnosis of subclinical FE compared to using either test alone, which if used at the individual level will result in fewer cattle being assigned the wrong FE status. This will also apply at the herd level, with combined testing producing fewer false-positive herd test results than using one enzyme alone. This is particularly important for monitoring the efficacy of FE control measures when the expectation should be that the proportion of cattle with FE is very low.

Genomic Tools for the Identification of Loci Associated with Facial Eczema in New Zealand Sheep.

Facial eczema (FE) is a significant metabolic disease that affects New Zealand ruminants. Ingestion of the mycotoxin sporidesmin leads to liver and bile duct damage, which can result in photosensitisation, reduced productivity and death. Strategies used to manage the incidence and severity of the disease include breeding. In sheep, there is considerable genetic variation in the response to FE. A commercial testing program is available for ram breeders who aim to increase tolerance, determined by the concentration of the serum enzyme, gamma-glutamyltransferase 21 days after a measured sporidesmin challenge (GGT21). Genome-wide association studies were carried out to determine regions of the genome associated with GGT21. Two regions on chromosomes 15 and 24 are reported, which explain 5% and 1% of the phenotypic variance in the response to FE, respectively. The region on chromosome 15 contains the β-globin locus. Of the significant SNPs in the region, one is a missense variant within the haemoglobin subunit β (HBB) gene. Mass spectrometry of haemoglobin from animals with differing genotypes at this locus indicated that genotypes are associated with different forms of adult β-globin. Haemoglobin haplotypes have previously been associated with variation in several health-related traits in sheep and warrant further investigation regarding their role in tolerance to FE in sheep. We show a strategic approach to the identification of regions of importance for commercial breeding programs with a combination of discovery, statistical and biological validation. This study highlights the power of using increased density genotyping for the identification of influential genomic regions, combined with subsequent inclusion on lower density genotyping platforms.

EVALUATION OF PATCH TESTING IN CONTACT DERMATITIS PATIENTS ATTENDING TERTIARY CARE CENTRE IN KARAIKAL

Introduction: Allergic contact dermatitis (ACD) is a growing concern due to increased use of cosmetics and topical medications routinely and exposure to a large number of allergens on day-to-day basis. Patch testing is a reliable method for detecting the causative antigens in suspected cases. Aims And Objectives: To assess the demographic profile, pattern of ACD, and patch test profile of suspected cases of ACD attending contact dermatitis clinic of our department. Materials And Methods: It was a prospective study in which all the patients with suspected ACD attending OPD of department of dermatology over a 3 month period were analysed. Patch testing was done using the most common antigens primarily, and other batteries were used depending on patient requirement and availability. Results: A total of 50 patients were enrolled in the contact dermatitis clinic over a period of 3 months. Hand eczema was the most common pattern seen in 23 cases followed by feet eczema, hand and foot eczema, facial eczema, forearm and leg eczema and photoallergic contact eczema. A total of 32 (64%) gave positive patch test results, with nickel sulfate being the most common allergen identified followed by cobalt sulfate &amp; potassium dichromate. Conclusion: Common allergens identified in our study were more or less similar to studies from other parts of India

Dermatitis in Sun-Exposed Areas in a 4-year-old Boy

Dermatitis in Sun-Exposed Areas in a 4-year-old Boy

Quantification of zinc concentrations in serum, milk and faeces of dairy cattle as a measure of effective zinc supplementation for management of facial eczema

Aims: To investigate the relationship between Zn concentrations in serum and those in milk or faeces, and to assess the ability of the Zn concentrations in milk, serum and faeces to predict intake of ZnO in dairy cattle. Method Seventy cows from one commercial farm in the Waikato region of New Zealand received one of seven dose rates (0, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5 g/100 kg bodyweight (BW)) of ZnO given by oral drench, every morning, for 7 consecutive days. Every afternoon, milk and blood samples were collected from all cows. Free-catch faecal samples were collected during the afternoon milking on 3 days throughout the trial. Linear mixed models were used to assess the relationship between the concentration of Zn in serum and that in milk, and in faeces, respectively, and the relationship between dose rate of ZnO and concentrations of Zn in serum, faeces and milk, respectively. Receiver operating characteristic curve analysis was used to determine the ability of the Zn concentration in serum, milk and faeces to predict that a cow had been treated with a dose of ZnO ≥2.5 g/100 kg, the industry-recommended dose rate needed to protect against facial eczema. Results: A 1-µmol/L increase in Zn concentration in milk was associated with a 0.14 (95% CI=0.11–0.17) µmol/L increase in Zn concentration in serum. Zn concentration in faeces was scaled by its SD; a 1 SD increase was associated with a 1.83 (95% CI=0.54–3.12) µmol/L increase in zinc concentration in serum. Zn concentrations in serum and faeces increased with increasing dose rates of ZnO. No differences in Zn concentrations in milk were noted between animals dosed with 1.5–3.5 g ZnO/100 kg BW, inclusive. At the optimal threshold for Zn concentration in serum, 22 µmol/L, the sensitivity was 0.76 (95% CI=0.69–0.82) and specificity 0.85 (95% CI=0.80–0.89). For the concentration of Zn in faeces, the optimal threshold was defined as 17.36 mmol/kg, with a corresponding sensitivity of 0.84 (95% CI=0.84–0.85) and specificity of 0.85 (95% CI=0.73–0.94). At the optimal threshold for the Zn concentration in milk (76.6 µmol/L), the sensitivity was lower than the other two sample types at 0.59 (95% CI=0.52–0.67), but with a similar specificity of 0.84 (95% CI=0.79–0.88). Conclusions and clinical relevance: The concentration of Zn in milk shows promise as an initial screening test to identify dairy farms that do not provide adequate zinc to provide protection against FE.

Health Information Integration Based on Network Platform in Postpartum Maternal and Infant Health Care

Objective: The self-care ability of puerpera is poor, and their health knowledge of maternal and infant and care skills is relatively poor. The aim of our study was to investigate the effect of health information integration based on network platform in the postpartum maternal and infant health care. Methods: A total of 80 maternal women admitted to our hospital from September 2018 to March 2019 were randomly divided into a control group and a study group, with 40 patients in each group. The puerpera in control group received regular telephone visits after discharge. The puerpera in study group received health information integration based on network platform. The uterus recovery of puerpera in two groups at 42 days postpartum, as well as the lochia, bloating, nipple splitting and breastfeeding behaviors were compared. The time of jaundice regression and umbilical cord detachment of neonates in t two groups, as well as the incidence of facial eczema and umbilical inflammation were compared. Results: The uterus recovery rate and exclusive breastfeeding rate of puerpera in study group were higher than those in the control group at 42 days postpartum, and the incidences of abnormal lochia, swollen breasts, and nipple splitting were lower than those in the control group. The difference between the two groups was statistically significant (P &lt; 0.05). The neonates in study group were lower than the observation group in terms of the days of jaundice regression, facial eczema, and umbilical inflammation. The difference between the two groups was statistically significant (P &lt; 0.05). However, there was no significant difference in the days of umbilical cord shedding (P &gt; 0.05). Conclusions: The health information integration based on network platform in postpartum maternal and infant health care can effectively improve maternal breastfeeding compliance and reduce the adverse symptoms of maternal and neonatal discharge.