Lotion Research Articles

Protective, Anti-Inflammatory, and Anti-Aging Effects of Soy Isoflavones on Skin Cells: An Overview of In Vitro and In Vivo Studies

Isoflavones are found in numerous plant species within the Leguminosae family; however, soy isoflavones are particularly significant in practice and have been extensively studied in recent years. The health-promoting potential of orally administered soy isoflavones is widely documented in the scientific literature, and many review articles have been developed to highlight their significance. However, it should be noted that soy-isoflavone-rich extracts and isolated soy isoflavones, such as genistein and daidzein, are also often applied topically as ingredients in many formulations, including face creams, tonics, and emulsions. New delivery systems are continuously being developed to enhance the skin permeability of isoflavones, thus improving their efficacy. In this context, their direct activity on skin cells is an important aspect of scientific research. The anti-inflammatory, protective, and antioxidant properties of isoflavones and soy extracts make them promising cosmetic ingredients with anti-aging potential because inflammation and the accumulation of reactive oxygen species (ROS) can lead to structural and functional changes in skin cells, accelerating the aging process. This review provides an overview of research on the impact of the application of soy isoflavone extract and soy-derived isoflavones on skin cells, with a focus on the documented molecular mechanisms underlying their effects. This study aims to offer essential insights to aid in the development of functional cosmetics and future clinical applications.

Analysis of Factors that Influence Brand Switching Behavior in Hand and Body Lotion Cosmetic Products

This research aims to determine what factors influence the brand switching behavior of hand and body lotion cosmetic products among women in Surabaya and also wants to know the dominant factors. This type of research is quantitative research with descriptive research methods. The population in this research is users of hand and body lotion cosmetic products in Surabaya. The sample in this research was 150. The sampling technique used was the purposive sampling method. The analysis used is factor analysis with the help of the IBM SPSS 25 program. The results of the research show that 10 factors influence women's brand switching behavior in Surabaya for hand and body lotion cosmetic products, namely e-commerce promos, reference groups, product quality, local brand, product bundling, variety seeking, online promotion, product packaging, price, and product knowledge. Of these 10 factors, the e-commerce promos factor is the dominant factor. Keywords:Brand Switching, Cosmetic Products, Factor Analysis.

Formulasi dan Uji Aktivitas Anti-aging Sediaan Hand Cream yang Mengandung Ekstrak Etanol Kulit Buah Nanas (Ananas comosus (L.) Merr.)

Hand skin that is often exposed to the sun easily loses moisture and is more rough. Hand cream is a care product that is applied to the palms and backs of the hands that can help restore hydration and skin function due to dry and rough skin. Pineapple peel contains flavonoids, vitamin C, and bromelain enzymes that has potential to be formulated into anti-aging preparations. This research aims to formulate ethanol extract of pineapple peel (Ananas comosus (L.) Merr.) into hand cream and to test the effectiveness as anti-aging agent. This research included making extracts by percolation method using 70% ethanol solvent, testing the antioxidant activity of pineapple peel extract using DPPH method, and hand cream formulations with the addition of pineapple peel extract with respective concentration of 0% (F0), 5% (F1), 7.5% (F2), and 10% (F3). Evaluation of hand cream preparations included organoleptic test, homogeneity, emulsion type, pH, viscosity, and physical stability at room temperature storage for 12 weeks and cycling test. Anti-aging effectiveness testing was carried out during the 4 weeks treatment period, by measuring parameters such as moisture, pores, blemishes and wrinkles on the skin of the backs of volunteers' hands which were measured once a week using a skin analyzer. The results of the antioxidant activity test of the ethanol extract of pineapple peel were included in the strong category with an IC50 value of 88.21 µg/mL. The hand cream preparation produced was homogeneous, O/W emulsion type, pH value 5.09-6.56, viscosity value 4086.76-6104.96 cPs, stable during 12 weeks of storage at room temperature and stable in the cycling test for 4 weeks. Hand cream preparations with a concentration of 10% have better effectiveness than 0%, 5% and 7.5% which results in an average percent moisture recovery of 77.60%, pores 62.92%, blemishes 55.65%, and wrinkles 45.92%.

A comparative evaluation of a commercially available kojic acid and arbutin-containing test product with a test regime in the treatment of hyperpigmentation

Background: The study compared the effectiveness of kojic acid and arbutin-containing lotion (alone) with arbutin-containing facewash and kojic acid and arbutin-containing lotion in the reduction of pigmentation. Methods: The study compared the test product (lotion) and the test regime (lotion + facewash) over a period of 45 days. In both test groups, a thin layer of advance body lotion was applied to the face, neck, and upper trunk. In the test regime group (TRG), these areas were washed with advance facewash before the lotion was applied. Both groups used sunscreen (with a sun protection factor of 50). The primary outcomes measured were (i) skin radiance and skin pigmentation, (ii) skin gloss, and (iii) skin hydration. The secondary outcomes measured were clinical evaluation and a subjective self-assessment for tolerance and perception of the product. Results: The study included 61 participants. The TRG showed a statistically significant increase in skin hydration (at 21 days) and skin gloss compared to the test product group (TPG) (at 21 and 45 days) (p<0.05). The majority of participants in both groups reported a visible reduction in pigmentation and improved facial glow and hydration as compared to baseline. No serious adverse effects were reported. Conclusions: The use of kojic acid and arbutin-containing lotion alone and arbutin-containing facewash with the lotion led to significant improvements in skin radiance, lightening, gloss, and hydration as compared to the baseline, with the TRG showing significantly better clinical results than the TPG in terms of skin hydration and gloss.

The treatment efficacy of 7.5% dapsone gel in papulopustular rosacea: a prospective study

Introduction Topical dapsone has a level A recommendation for the treatment of papulopustular rosacea; however, its treatment efficacy has not been studied previously. The aim of this study is to evaluate the safety and efficacy of topical 7.5% dapsone gel applied once daily at night in the treatment of papulopustular rosacea. Patients and methods This is a prospective study including female papulopustular rosacea patients with a minimum IGA score of 2. The patients were recruited at two different outpatient clinics by two independent dermatologists. The patients were prescribed 7.5% dapsone gel (same brand) for once-daily use at night. No other topical or systemic treatment modalities were allowed to be used during the study except for a sun protection factor 50 sunscreen and an emollient face cream. The patients were evaluated with the total lesion counts and IGA scores at weeks 0, 4 and 8 by two independent dermatologists. The side effects of burning, stinging, pain, erythema, and exfoliation were questioned during the follow-up visits. Results All 32 recruited patients (18–70) completed the study. The mean lesion counts of the patients were 22.10 ± 8.95 on the initial visit, 11.90 ± 6.49 on the 4th week follow-up and 3.87 ± 3.76 on the 8th week follow up. The mean IGA scores of the patients were 3.06 ± 0.81 on the initial visit, 2.10 ± 0.87 on week 4 and 0.74 ± 0.73 on week 8. The decrease in the mean lesion count and IGA score of the patients in weeks 4 and 8 were statistically significant (p = 0.000 for all). This decrease was independent of the patient’s age (p > 0.005). No side effects were reported. Conclusions The 7.5% topical formulation of dapsone is effective for papulopustular rosacea both on the first and second months of the treatment regardless of the age of the patient. Its safe side effect profile suits for a comfortable use in rosacea patients with a decreased skin tolerance.

Pain modulates brain potentials and behavioral responses to unfairness.

Pain may initially contribute to the evolution of moral decision-making as it elicits avoidance behavior. The current study aims to support this perspective by conducting a behavioral study to investigate whether pain leads to a self-oriented tendency, and an exploratory electroencephalogram (EEG) study to examine how pain affects moral decision-making. In Experiment 1, 34 participants were recruited and treated with both capsaicin (pain condition) and hand cream (control condition) in separate days. After treatment, they were asked to complete a third-party punishment task. Results showed that pain increased punishment and decreased compensation towards unfair allocations in the task. In Experiment 2, 68 participants with either pain or control treatment participated in an EEG experiment. It revealed that pain enlarged the disparity of late positive potential (LPP) between fair and unfair situations, suggesting that individuals in pain may exert more cognitive effort when facing unfair allocations. Meanwhile pain did not affect the early components P2 and the medial frontal negativity, indicating unaffected attentional or anticipatory responses towards unfairness. It demonstrates that pain can effectively modulate responses to unfairness, manifesting as a self-oriented approach with negative consequences for others. It suggests a potential evolutionary impact of pain on moral decisions.

Consumers Prefer Products That Work Using Directionally Consistent Causal Chains

Abstract Products often aim to help consumers achieve desired outcomes such as increasing energy levels or removing fabric stains. These products typically work via rich causal paths. The current research suggests that the structure of these paths influences consumer judgments of product efficacy. In particular, sequential steps in these paths can evoke distinct directionalities—either increasing or decreasing variables in each step along the way. For example, a face cream could be described as “increasing the turnover of skin cells to reduce wrinkles.” Under our framework, the action influencing skin cells would correspond to increasing directionality, while the action influencing wrinkles would correspond to decreasing directionality. Ten experiments provide evidence that consumers prefer products with directionally consistent causal chains (ie, all steps evoking the same directionality) over those with directionally inconsistent ones (ie, steps evoking contrasting directionalities). This occurs because consumers find directionally consistent causal chains easier to process which in turn leads them to infer higher efficacy from products working via such consistent chains. These findings advance our understanding of how consumers evaluate product descriptions and provide prescriptions for marketers tasked with composing product descriptions to convey efficacy.

The Influence of EXO Brand Ambassadors and Customer Engagement on Purchase Intention of Scarlett Whitening Body Lotion Tube Products on Social Media

This study aims to determine the effect of EXO brand ambassador and customer engagement on purchase intention of Scarlett Whitening Body Lotion Tube products on social media both partially and simultaneously and to determine the dominant variable on purchase intention of Scarlett Whitening Body Lotion Tube products on social media. This type of research is quantitative research with causal methods. The target population of this study are all prospective consumers and users of Scarlett Whitening Body Lotion Tube products on twitter and instagram. The research sample used was 100 respondents who were distributed through questionnaires. The sampling technique in this study was probability sampling with simple random sampling. Based on the results of the study, it shows that brand ambassadors do not have a positive and significant influence on the purchase intention of Scarlett Whitening Body Lotion Tube products, while customer engagement has a positive and significant influence on the purchase intention of Scarlett Whitening Body Lotion Tube products, brand ambassadors and customer engagement simultaneously have a positive and significant influence on the purchase intention of Scarlett Whitening Body Lotion Tube products, and customer engagement is a variable that has a dominant influence on the purchase intention of Scarlett Whitening Body Lotion Tube products on social media.

Use of facial cosmetics and their effects on skin among female students of Bayero University Kano, Nigeria

Cosmetics are used for cleansing, beautifying, enhancing attractiveness, or altering appearance and commonly applied by young women. This study examined the use and effects of cosmetics on the skin of female students at Bayero University Kano, Nigeria. A sample of 360 students from five faculties were randomly selected. Data on age, purpose, type, frequency of use, and effects of cosmetic products were collected. The age groups were divided into younger (18-25 years) and older (25+ years). Pearson’s Chi-square test assessed associations between age, ethnicity, and cosmetic use. The study found that facial creams (83.1%), lipstick (52.2%), eyeliners (54.7%), mascara (33.1%), eyelashes (12.5%), eyeshadow (16.1%), and foundation (15.6%) were the most commonly used cosmetics. Usage was mostly occasional (63%) or daily (37%), with 88% preferring daytime application. Significant associations were found between age and usage purpose (p=0.043), and between ethnicity and choice of cosmetics (p=0.030). Reported side effects included acne (23.3%), bleaching (25.7%), pigmentation (12.2%), rashes/itching (13.9%), irritation (5.2%), skin hardening (4.5%), and other complications (15.3%). Eye-related issues included redness (52.2%), itching (20.2%), soreness (15.4%), puffiness (3.5%), and miscellaneous problems (8.8%). Lip problems were primarily cracking (70.8%), swelling (16.9%), and bumps (12.3%). In conclusion, the use of facial cosmetics is prevalent among students, mainly for occasional use and primarily during the day. The purpose of cosmetic use varies with age and ethnicity. The most common side effects are skin pigmentation, eye redness, and swollen lips.

A Review on Formulation of Body Lotion

The body is shielded by protective layers of skin. A plant-based herbal body lotion provides soothing hydration. Common ingredients often feature aloe vera, known for its healing properties, pain relief, and moisture retention. For centuries, it has been used to treat skin burns and wounds. Aloe vera, honey, glycerin, rose water, and triethanolamine were selected for the formulation of the herbal body lotion. Evaluation parameters were conducted to ensure that the formulation is safe for human use. The aloe vera body lotion was created using these ingredients, which include aloe vera known for its antimicrobial and hydrating properties, protecting the skin from microbial damage while providing moisture. In conclusion, this herbal body lotion is designed for topical application. Aloe vera enhances the lotion's synergistic and moisturizing effects on the skin. Herbal remedies are gaining worldwide popularity, and the combination of aloe vera, honey, coconut oil, Lavender oil, and glycerin in this formulation is an excellent approach. These formulations were assessed using various evaluation parameters, including homogeneity, appearance, after-feel, acid value, pH measurement, irritancy test, viscosity, accelerated stability testing, subjective properties, spreadability, type of emulsion test, sensitivity test, washability test, statistical analysis, in vitro permeation studies, thermal stability tests, total fatty matter determination, water content analysis, and patch tests. The aim of this review is to compile information on different herbal lotion formulations and their evaluations. Numerous researchers have studied herbal lotion formulations, and this knowledge can assist other researchers in developing novel herbal cosmetic formulations featuring new ingredients.

Phthalate Esters in Different Types of Cosmetic Products: A Five-Year Quality Control Survey.

Phthalate esters are commonly included in the formulations of cosmetics and related products in order to retain fragrance, enhance flexibility (i.e., by acting as plasticizers), facilitate the dissolution and dispersion of other ingredients, and improve the overall texture and sensory experience of the products. This study aimed to assess the presence and concentrations of phthalates in cosmetics by analyzing a comprehensive set of samples collected over a period of five years (2016-2020). The concentrations of nine different phthalate esters (BBP, DEHP, DNOP, DPP, DBP, DIPP, DMEP, DMP and PIPP) in 1110 cosmetics samples from France and Spain were determined by gas chromatography-mass spectrometry. The samples were included in five categories: soaps and shampoos; hand and body creams; lip gloss and lipsticks; nail polish; and facial makeup and skincare products. Some of the samples (4.86%) contained at least one phthalate at concentrations above the threshold limit (1 µg mL-1). Variable concentrations of different phthalates were determined in the 54 positive samples identified. DEHP was the most frequently detected phthalate, followed by DBP. The findings revealed different profiles according to the different categories of cosmetics and the phthalates detected in each. The results were critically compared with those obtained in various previous studies.

Pengaruh Brand Image dan Brand Trust Terhadap Brand Loyalty Produk Hand & Body Lotion Citra (Studi Pada Followers Akun Shopee Unilever Beauty Shop)

This research aims to determine and analyze the influence of brand image and brand trust on brand loyalty of Citra hand & body lotion products (Study on followers of the Unilever Beauty Shop shopee account). This research uses a quantitative type of research. Variable measurement in this research uses a Likert scale. The population in this study are followers of the Unilever Beauty Shop Shopee account. The sample taken in this research was 100 people using purposive sampling technique. Data collection in this research used a questionnaire. This research uses SPSS for Windows version 29. The results of the research show that Brand Image and Brand Trust have a significant effect on Brand Loyalty, Brand Image has a significant effect on Brand Loyalty and Brand Trust has a significant effect on Brand Loyalty.

Hand Carriage of Yeast in Student of Medicine, Nursing, and Medical Laboratory Science: Impact of Infection Control Measures.

We studied yeast hand carriage of 260 healthcare students. We isolated yeasts in 27 students (10.4%), without differences between medicine, nursing, and medical laboratory science programs and gender. A significant lower prevalence of carriage was shown in the clinical cycle (2.7%) compared to the basic cycle (13.5%) (p = 0.022) and the preclinical cycle (13.5%) (p = 0.014). Increased handwashing frequency and the use of alcohol gel and antiseptic soap decreased yeast carriage. Students who applied moisturizing hand cream two or more times a day had a lower frequency of yeast carriage (3.4%) than those who did not use it or used it once a day (16.5%), showing a significant difference (p = 0.016). The most prevalent species was C. parapsilosis sensu stricto (81.5%), followed by Meyerozyma guilliermondii (C. guillermondii) (7.4%), Trichosporon mucoides (7.4%), and R. mucilagenosa (3.7%). One case showed mixed carriage of C. parapsilosis and C. albicans. All strains were sensitive to voriconazole, caspofungin, and anidulafungin. This study shows hand carriage of yeast in health students, mainly by C. parapsilosis, and the frequency of infection control measures and moisturizing hand cream is associated with colonization control.

Extraction, Characterization and Evaluation of Health Applications of Moringa oleifera Seed Oil

In this study, the seeds of Moringa oleifera (MO) plant grown in the Adamawa Region of Cameroon were valorized by extracting their oil using mechanical expression. The oil was allowed to clarify through by gravity and an oil yield of 26.07% was obtained. The extracted MO oil was subjected to physicochemical characterization giving the following results; the density of the oil was 0.896 g/mL, a refractive index of 1.468, a viscosity of 49.80± 0.30 mPa.s, an acid value of 2.69%, a peroxide value of 3.7 meq of O2/kg of oil, a saponification value of 189.34 mg of KOH/g of oil and an iodine index of 67.79g/100g of oil. The determination of relevant secondary metabolites by titration revealed a flavonoid content of 0.66 mg GAE/g, total phenol content of 9.7 mg QE/g, carotenoid content of 0.25 mg beta-caro/g and antioxidant activity gave an IC50 concentration of 17.5 mg/mL. Determination of the fatty acid profile revealed that oleic acid (78.45%) makes up the predominant component in the MO seed oil. The chemical composition of the MO seed oil was further verified by IR spectroscopy whose spectral interpretation revealed a predominance of fatty acid moieties in the oil. From these results, it appears that Moringa oleifera seed oil has moisturizing, antioxidant, anti-inflammatory and nourishing properties and therefore the oil is a potent raw material or bioactive substance in the formulation of cosmetic products like creams for body lotion to combat skin infections and the MO seed can find pharmaceutical applications amongst others.

50564 Novel Natural Moisturizing Factor and Lipid-Containing Face Cream Induces Aquaporin-3 and Filaggrin Expression Associated with Barrier Improvements and Sustained Clinical Hydration in Extra-Dry Skin

50564 Novel Natural Moisturizing Factor and Lipid-Containing Face Cream Induces Aquaporin-3 and Filaggrin Expression Associated with Barrier Improvements and Sustained Clinical Hydration in Extra-Dry Skin

Indoor Emission, Oxidation, and New Particle Formation of Personal Care Product Related Volatile Organic Compounds.

Personal care products (PCPs) contain diverse volatile organic compounds (VOCs) and routine use of PCPs indoors has important implications for indoor air quality and human chemical exposures. This chamber study deployed aerosol instrumentation and two online mass spectrometers to quantify VOC emissions from the indoor use of five fragranced PCPs and examined the formation of gas-phase oxidation products and particles upon ozone-initiated oxidation of reactive VOCs. The tested PCPs include a perfume, a roll-on deodorant, a body spray, a hair spray, and a hand lotion. Indoor use of these PCPs emitted over 200 VOCs and resulted in indoor VOC mixing ratios of several parts per million. The VOC emission factors for the PCPs varied from 2 to 964 mg g-1. We identified strong emissions of terpenes and their derivatives, which are likely used as fragrant additives in the PCPs. When using the PCPs in the presence of indoor ozone, these reactive VOCs underwent oxidation reactions to form a variety of gas-phase oxidized vapors and led to rapid new particle formation (NPF) events with particle growth rates up to ten times higher than outdoor atmospheric NPF events. The resulting ultrafine particle concentrations reach ∼34000 to ∼200000 cm-3 during the NPF events.

New clinical approach in facial mild-moderate acne: Re-stabilization of skin microbiota balance with a topical biotechnological phytocomplex.

Dysbiosis of the skin microbiota has been identified as a key factor in the development of acne. This study was aimed to evaluate the effect of a facial cream gel containing a biotechnological phytocomplex, niacinamide and succinic acid on the bacterial diversity of subjects with mild-moderate acne and its clinical benefits due to microbiota changes. Open-label, clinical study in 44 subjects with mild-moderate acne treated with a facial cream gel for 8 weeks. Bacterial diversity was analyzed by 16S rRNA gene sequencing of skin samples. Clinical effects were evaluated using the IGA acne severity scale, biometric measurements, and safety. After 56 days of product's use, an increase in alpha and beta diversity was found (p < 0.01), with a decrease in the relative abundance of C. acnes (48.99% vs. 38.83%, p < 0.001). Regarding clinical results, a decrease in acne severity on the IGA scale (27.33%, p < 0.001), number of non-inflammatory and inflammatory lesions (respectively: 31.12%, p = 0.05; 47.27%, p < 0.001), amount of sebum (89.00%, p < 0.01) and erythema (15.35%, p < 0.01), was found. [Correction added on 19 September 2024, after first online publication: In the preceding sentence, "42.27%" has been changed to "47.27%" in this version.] Responder analysis of the IGA score showed that 61.36% of patients improved by at least one point at day 56. The product was well tolerated throughout the study. The use of the facial cream gel on skin was effective in rebalancing the microbiota, inhibiting biofilm formation and other virulence factors, reducing the number of mild-moderate acne lesions and sebum secretion, and consequently improving acne's severity.

Effect of vehicle on the in vitro penetration and metabolism of genistein and daidzein in ex vivo skin explants and the Phenion full-thickness skin model.

In a read-across assessment of the safety of genistein and daidzein in cosmetic products, additional information was required to account for differences in their systemic exposure after topical application in a typical body lotion formulation. Therefore, we measured the penetration and metabolism of two doses (3 and 30 nmoles/cm2) of genistein and daidzein applied in ethanol and in a body formulation to fresh pig skin, fresh and frozen human skin, and PhenionFT models. Both chemicals readily penetrated all skin models when applied in ethanol. The same sulfate and glucuronide metabolites were formed in fresh pig skin, fresh human skin, and PhenionFT models, which also all demonstrated that (a) these pathways could be saturated between 3 and 30 nmoles/cm2 and (b) the extent of metabolism of daidzein was lower than genistein. Although the relative amounts of radiolabeled chemical in human skin and medium compartments were altered by freezing, their overall bioavailability was not affected. The greatest impact on the bioavailability and distribution of both chemicals was observed when they were applied in the formulation. Most of the dose applied in the formulation was retained on the skin surface, especially at 30 nmoles/cm2 (60%-90%), resulting in much lower amounts in the medium and/or skin. In conclusion, all four skin models demonstrated first-pass metabolism of genistein and daidzein and a marked alteration in their disposition by applying them in a body lotion formulation. This supports the use of fresh pig skin and PhenionFT models as alternatives to human skin for investigating skin metabolism and formulation effects for these two chemicals. The results were used to develop the dermal module of a PBPK model and dose setting for organ-on-chip experiments. They could also be used to refine internal exposure estimates in regulatory safety assessments.

Influence of collagen peptide supplementation on visible signs of skin and nail health and -aging in an East Asian population: A double blind, randomized, placebo-controlled trial.

A healthy skin provides protection against intrinsic and extrinsic factors. Skin aging is characterized by structural and morphological alterations affecting skin health, integrity, and functionality, resulting in visible aging signs. The primary objective of this study was to assess the effect of a collagen peptide dietary supplement on skin aging in the East Asian population. Eighty-five healthy women, aged from 43 to 65 years old, were randomly assigned to the collagen supplement (CP, 5 g) or placebo (maltodextrin, 5 g) group. To standardize daily skin care, the volunteers in both groups used a specific face cream for 28 days prior to and throughout the supplementation period, creating an equal baseline for the assessment of the efficacy of CP on several skin parameters. At baseline, day 28 and day 84, the following hallmarks of skin and nail aging were assessed: dermis density, skin moisture and elasticity, wrinkle visibility, beauty perception, and nail color. After 84 days, a significant improvement of dermis density and skin moisture was observed in the collagen peptides group compared to the placebo group. Positive effects on skin elasticity, wrinkle visibility, nail color, and overall beauty perception were already observed within 28 days of supplementation in the CP group, while the same effects in the placebo group were only observed after 84 days. Taken together, these results show that, in addition to a standardized skin care, daily supplementation with 5 g of collagen peptides positively affects visible signs of skin and nail aging in the East Asian population.

The Influence of Product Reviews on Purchasing Decisions for Scarlett Whitening Body Lotion on Sociolla E-commerce, Mediated by Price

This study aims to determine the influence of price and product reviews on purchasing decisions for Scarlett Whitening Body Lotion on E-Commerce Sociolla, which is mediated by price. This research uses a questionnaire technique and is distributed to respondents. The population in this research was women aged 20 - 39 years who lived in Jatiwaringin Village, Bekasi City, totalling 7,469 people and a sample of 380 people was obtained. Then, the data processing uses GMA. The results of this research show that based on Hypothesis Testing (T-Statistics and P-Value), Product Price has a positive and significant effect on the Decision to Purchase Scarlett Whitening Body Lotion at Sociolla E-Commerce; Product reviews have a positive and significant influence on purchasing decisions for Scarlett Whitening Body Lotion on E-Commerce Sociolla; and Product Reviews have a positive and significant influence on the Purchase Decision for Scarlett Whitening Body Lotion on E-Commerce Sociolla which is mediated by price.